A5027371905- COVID-19 Clinical Research Studies
- Traditional and Medicinal Uses of Annonaceae
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cocoa and Sweet Potato Agronomy
- Liver Disease Diagnosis and Treatment
- Sepsis Diagnosis and Treatment
- Phytochemical compounds biological activities
- Potato Plant Research
- Phytochemicals and Antioxidant Activities
- Peptidase Inhibition and Analysis
- Tea Polyphenols and Effects
- Natural Antidiabetic Agents Studies
- Wound Healing and Treatments
- COVID-19 Impact on Reproduction
- COVID-19 epidemiological studies
- Diet, Metabolism, and Disease
- Digital Mental Health Interventions
- Cancer survivorship and care
- Ethics in medical practice
- Planarian Biology and Electrostimulation
- Mental Health Research Topics
- Dermatologic Treatments and Research
- Histone Deacetylase Inhibitors Research
- Hibiscus Plant Research Studies
Universidad de Colima
2016-2025
Mexican Social Security Institute
2024-2025
University of Padua
2016
COVID-19 vaccines primarily prevent severe illnesses or hospitalization, but there is limited data on their impact during hospitalization for seriously ill patients. In a Mexican cohort with high mortality, study assessed vaccination's effects. From 2021 to 2022, 462 patients 4455 hospital days were analyzed. The generalized multivariate linear mixed model (GENLINMIXED) binary logistic regression link, survival analysis and ROC curves used identify risk factors death. results showed that the...
Traditional and complementary medicine (T&CM) plays a significant role in healthcare practices among professionals oncology patients Mexico, reflecting its cultural importance. This study aimed to analyze the prevalence, frequency, factors associated with T&CM use these two groups, highlighting differences perceptions. A total of 382 individuals participated, including 152 230 patients. The findings revealed that while was similarly prevalent (85.7%) (90.8%), frequent (≥2 times per...
Background/Objectives: Metastatic prostate cancer remains a major clinical challenge, with limited therapeutic options. Doxycycline, tetracycline antibiotic anti-inflammatory properties, has shown potential as an adjunctive therapy. This study aimed to evaluate its efficacy in reducing prostate-specific antigen (PSA) levels and improving quality of life patients receiving standard treatment for metastatic cancer. Methods: phase II, double-blind, randomized controlled trial included 45...
Background and Objectives: Arteriovenous fistulas (AVFs) are the preferred vascular access for hemodialysis due to their impact on patient outcomes, including survival, infection rates, overall quality of life. Despite strong recommendations favoring AVF, gaps in AVF utilization remain, influenced by clinical, demographic, systemic factors. This study is first analyze survival outcomes associated with different dialysis types, adjusting key demographic variables, other comorbidities over...
Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, with growing concerns about impact omega-6 polyunsaturated fatty acids (n-6 PUFAs) on cardiovascular health. This study aims to evaluate relationship between serum linoleic acid (LA) levels and waist-to-height ratio (WHtR), a recognized risk marker, in children. The research was conducted two parts. First, global analysis publicly available data (2019–2021) explored association nutritional factors CVD prevalence...
This study examines how COVID-19 restrictions influenced the location of first sexual intercourse among Mexican university students. The sample included 221 students who initiated activity during pandemic and 162 did so before or after. During pandemic, there was a significant change, with reduction in relations at parents' houses (from 54.9% to 40.3%) an increase sex rented/borrowed 9.3% 19.5%) outdoor spaces 2.5% 9.5%). However, all times, even restrictions, house remained most common site...
Moringa oleifera (MO) is a native tree of Asia and cultivated in some areas Mexico as part traditional horticulture. The aim the present study was to compare efficacy MO infusion vs. ethanolic extract for simultaneous treatment nonalcoholic fatty liver (NAFLD), hyperlipidemia, hyperglycemia murine model fed with high-fat diet (HFD). BALB/c mice were balanced (healthy control) or an HFD 6 months. With this, NAFLD established before starting therapeutic intervention two phytochemical analysis...
(SO) is one of the most widely used plants in traditional medicine worldwide. In present study, effect an ethanolic extract
Annona purpurea, known in Mexico as "cabeza de negro" or "ilama", belongs to the Annonaceae family. Its roots are employed folk medicine several regions of Mexico. Taking that information into account, a chemical and biological analysis components present this species was proposed. Our results demonstrated dichloromethane (DCM) extract exclusively constituted by mixture five new acetogenins named annopurpuricins A-E (1-5). These compounds have an aliphatic chain 37 carbons with terminal α,β...
The severity of adenovirus infection or the success adenovirus-vectorized gene therapy largely depends on efficiency viral entry into cells. Various drugs can alter entry. This study evaluated effects dexamethasone, paracetamol, diclofenac, ibuprofen, and ketorolac cells in vitro vivo. SiHa cell cultures pretreated with ketorolac, no drug were exposed to Ad-BGal vector. percentage showing vector was quantified microscopically. In vivo, BALB-C mice for 7 days intravenously (IV) via oral (VO)....
Clinical data from hospital admissions are typically utilized to determine the prognostic capacity of Coronavirus disease 2019 (COVID-19) indices. However, as status and severity markers evolve over time, time-dependent receiver operating characteristic (ROC) curve analysis becomes more appropriate. The present assessed predictive power for death at various time points throughout patient hospitalization. In a cohort study involving 515 hospitalized patients (General Hospital Number 1 Mexican...
Vitamin D3 or calcitriol (VitD3) has been shown to have anticancer and anti-inflammatory activity in vitro models clinical studies. However, its effect on HPV-16-related cancer sparsely explored. In this study, we aimed determine whether monotherapy combination therapy with cisplatin (CP) reduces tumor growth affects survival systemic inflammation. Treatments were administered C57BL/6 mice tumors (TC-1 cells) as follows: (1) placebo (100 µL vehicle, olive oil, orally daily); (2) VitD3 (3.75...
In the ongoing fight against Coronavirus Disease 2019 (COVID-19), researchers are exploring potential treatments to improve outcomes, especially in severe cases. This includes investigating repurposing of existing medications, such as furosemide, which is widely available. study aimed evaluate impact furosemide on mortality rates among COVID-19 patients with or critical illness. We assessed a cohort 515 hospitalized adults who experienced high rate 43.9%. Using multivariate analysis adjusted...
Background: The COVID-19 pandemic significantly impacted mental health and substance use patterns, particularly among young adults. Objective: This study aimed to assess changes in anxiety, depression, self-esteem, university students Mexico before, during, after the pandemic. Methods: Using a repeated cross-sectional design, this was conducted with across three periods: pre-pandemic (2017 2019); during (2021); post-pandemic (2023). A total of 2167 were interviewed one periods. Standardized...
Annona purpurea is a species known in Mexico as "cabeza de negro". In folk medicine A. root used to treat patients with kidney diseases and cancer. Our recent studies demonstrated that this contains five acetogenins named annopurpuricins A-E, which are active against tumoural cell lines subnanomolar range.To develop an analytical method using high-performance liquid chromatography diode array detector (HPLC-DAD) quantify A-E different samples.To the sample treatment was carried out,...
In the United States, Chronic Kidney Disease (CKD) affects approximately 1 in 7 adults. Despite its significant impact, CKD awareness, education, and screening are often lacking among underserved Latine populations, leading to poorer health outcomes higher mortality rates. Various studies highlight crucial role of Community Health Workers (CHWs) improving within minority communities both domestically globally. However, there remains a gap research on acceptance effectiveness CHW-led...
Burn injuries impose challenges such as infection risk, pain management, fluid loss, electrolyte imbalance and psychological emotional impact, on healthcare professionals, requiring effective treatments to enhance wound healing. The present study evaluated the efficacy superoxidized electrolyzed solution (SES), with low (SES‑low) or high (SES‑high) concentrations of active species, alone in combination a formulation gel (G), comparison commonly prescribed for burn injury, including...
Breast cancer (BC) is the most common and main cause of mortality due to in women around World. Histone deacetylase 6 (HDAC6) a promising target for treatment BC. In present study, series novel 3‑carboxy‑coumarin sulfonamides, analogs belinostat, targeting HDAC6 were designed synthesized. The compounds synthesized purified through open‑column chromatography. Characterization was performed using spectroscopic techniques, including <sup>1</sup>H <sup>13</sup>C NMR, homonuclear heteronuclear...
Patients with diabetes have been reported to experience a higher prevalence of shoulder disorders compared those without or other medical conditions. However, the specific types injuries and extent functional impairment associated mellitus remain unclear. This study aimed assess association between injuries, as well degree in affected patients.
Breast cancer survivorship is a recognized risk factor for sexual dysfunction, with various clinical, sociocultural, and psychological factors potentially interacting differently across populations. This study compared anxiety, depression between females breast those without, aiming to identify associated factors. A total of 362 participated, including 227 dysfunction 135 controls. Among them, 195 are survivors, while 167 have no personal history cancer. Key variables were analyzed using...
Background: Annona muricata L. (guanabana) leaves are rich in bioactive compounds with potential antioxidant properties. In the state of Colima, both ethanolic extracts and infusions traditionally used folk medicine to address various ailments. This study aimed evaluate compare phytochemical composition activities A. from three geographic regions Mexico, a focus on how origin affects their Methods: Ethanolic were prepared analyzed using screening; DPPH, total capacity (TAC), phenolic content...