A5067212337- Nuclear physics research studies
- Quantum Chromodynamics and Particle Interactions
- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Nuclear Physics and Applications
- Advanced NMR Techniques and Applications
- Metabolism and Genetic Disorders
- Radiopharmaceutical Chemistry and Applications
- Atomic and Molecular Physics
- Aluminum Alloy Microstructure Properties
- RNA modifications and cancer
- Solidification and crystal growth phenomena
- Folate and B Vitamins Research
- Crystallization and Solubility Studies
- Astronomical and nuclear sciences
- X-ray Diffraction in Crystallography
- Photocathodes and Microchannel Plates
- Optics and Image Analysis
- High Temperature Alloys and Creep
- Biochemical and Molecular Research
- Quantum optics and atomic interactions
- Mitochondrial Function and Pathology
- Neurogenetic and Muscular Disorders Research
- Quantum and electron transport phenomena
- Semiconductor Quantum Structures and Devices
Moderna Therapeutics (United States)
2024
Thomas Jefferson National Accelerator Facility
2000-2012
North University of China
2011
Northwestern Polytechnical University
2008
University of Edinburgh
1996-2005
Institute of Nuclear Physics
2004
Argonne National Laboratory
2002
University of Glasgow
1999
Bhabha Atomic Research Centre
1997
Forschungszentrum Jülich
1991
The ratio of the proton's elastic electromagnetic form factors, G(E(p))/G(M(p)), was obtained by measuring P(t) and P(l), transverse longitudinal recoil proton polarization, respectively. For e-->p-->ep-->, G(E(p))/G(M(p)) is proportional to P(t)/P(l). Simultaneous measurement P(l) in a polarimeter provides good control systematic uncertainty. results for show decrease as Q2 increases from 0.5 3.5 GeV2, indicating first time definite difference spatial distribution charge magnetization...
The ratio of the proton elastic electromagnetic form factors, ${G}_{\mathit{Ep}}/{G}_{\mathit{Mp}}$, was obtained by measuring ${P}_{t}$ and ${P}_{\ensuremath{\ell}}$, transverse longitudinal recoil polarization components, respectively, for $\stackrel{\ensuremath{\rightarrow}}{e}p\ensuremath{\rightarrow}e\stackrel{\ensuremath{\rightarrow}}{p}$reaction in four-momentum transfer squared range 0.5 to $3.5\phantom{\rule{0.3em}{0ex}}\text{GeV}{}^{2}$. In single-photon exchange approximation,...
Abstract Propionic acidaemia is a rare disorder caused by defects in the propionyl-coenzyme A carboxylase α or β (PCCA PCCB) subunits that leads to an accumulation of toxic metabolites and recurrent, life-threatening metabolic decompensation events. Here we report interim analyses first-in-human, phase 1/2, open-label, dose-optimization study extension evaluating safety efficacy mRNA-3927, dual mRNA therapy encoding PCCA PCCB. As 31 May 2023, 16 participants were enrolled across 5 dose...
Messenger RNA (mRNA) therapeutics delivered via lipid nanoparticles hold the potential to treat metabolic diseases caused by protein deficiency, including propionic acidemia (PA), methylmalonic (MMA), and phenylketonuria (PKU). Herein we report results from multiple independent preclinical studies of mRNA-3927 (an investigational treatment for PA), mRNA-3705 MMA), mRNA-3210 PKU) in murine models each disease. All 3 mRNA exhibited pharmacokinetic/pharmacodynamic (PK/PD) responses their...
We have measured the spin structure functions $g_1$ and $g_2$ of $^3$He in a double-spin experiment by inclusively scattering polarized electrons at energies ranging from 0.862 to 5.07 GeV off target 15.5$^{\circ}$ angle. Excitation covered resonance onset deep inelastic regions. determined for first time $Q^2$ evolution $\Gamma_1(Q^2)=\int_0^{1} g_1(x,Q^2) dx$, $\Gamma_2(Q^2)=\int_0^1 g_2(x,Q^2) dx$ $d_2 (Q^2) = \int_0^1 x^2[ 2g_1(x,Q^2) + 3g_2(x,Q^2)] neutron range 0.1 GeV$^2$ $\leq Q^2...
We present measurements of the recoil proton polarization for d(γ→,p→)n reaction at θc.m.=90° photon energies up to 2.4 GeV. These are first data in this transfer with circularly polarized photons. The induced py vanishes above 1 GeV, contrary meson-baryon model expectations, which resonances lead large polarizations. However, Cx does not vanish inconsistent hadron helicity conservation. Thus, we show that scaling behavior observed d(γ,p)n cross sections is a result perturbative QCD. should...
We present measurements of the recoil proton polarization for 1H(→γ,→p)π0 reaction θπc.m.=60°–135° and photon energies up to 4.1 GeV. These are first data in this transfer with circularly polarized photons. Various theoretical models compared results. No evidence hadron helicity conservation is observed. Models that employ factorization not favored. It appears from strong angular dependence induced at 2.5 3.1 GeV a relatively high spin resonance or background amplitude might exist energy...
The recoil proton polarization was measured in the $^{2}\mathrm{H}$$(\stackrel{\ensuremath{\rightarrow}}{e},{e}^{\ensuremath{'}}\stackrel{\ensuremath{\rightarrow}}{p})n$ reaction Hall A of Thomas Jefferson National Accelerator Facility. electron kinematics were centered on quasielastic peak (${x}_{\mathit{Bj}}\ensuremath{\approx}1$) and included three values squared four-momentum transfer, ${Q}^{2}=0.43,1.00$ 1.61 (GeV/$c){}^{2}$. For ${Q}^{2}=0.43$ (GeV/$c){}^{2}$, missing momentum,...
We report a virtual Compton scattering study of the proton at low c.m. energies. have determined structure functions PLL−PTT/ϵ and PLT, electric magnetic generalized polarizabilities (GPs) αE(Q2) βM(Q2) momentum transfer Q2=0.92 1.76 GeV2. The GP shows strong falloff with Q2, its global behavior does not follow simple dipole form. rise then falloff; this can be interpreted as dominance long-distance diamagnetic pion cloud compensated higher Q2 by paramagnetic contribution from πN...
Virtual Compton Scattering (VCS) on the proton has been studied at Jefferson Lab using exclusive photon electroproduction reaction (e p --> e gamma). This paper gives a detailed account of analysis which led to determination structure functions P_LL-P_TT/epsilon and P_LT, electric magnetic generalized polarizabilities (GPs) alpha_E(Q^2) beta_M(Q^2) values four-momentum transfer squared Q^2= 0.92 1.76 GeV^2. These data, together with results VCS experiments lower momenta, help building...
We present a measurement of the spin-dependent cross sections for 3He over -->(e -->,e')X reaction in quasielastic and resonance regions at four-momentum transfer 0.1< or =Q2< =0.9 GeV2. The spin-structure functions have been extracted used to evaluate nuclear Burkhardt-Cottingham extended Gerasimov-Drell-Hearn sum rules first time. data are also compared an impulse approximation calculation exact three-body Faddeev region.
${}^{12}\mathrm{C}(\ensuremath{\gamma},pn)$ and $(\ensuremath{\gamma},pp)$ cross sections have been measured in kinematics which emphasize direct $2N$ knockout for ${E}_{\ensuremath{\gamma}}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}120--400\mathrm{MeV}$ ${\ensuremath{\theta}}_{p}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}23\ifmmode^\circ\else\textdegree\fi{}--152\ifmmode^\circ\else\textdegree\fi{}$. The both reactions peak strongly the $\ensuremath{\Delta}$-resonance region....
The 2H(e,e′p)n cross section was measured in Hall A of the Thomas Jefferson National Accelerator Facility near top quasielastic peak (xBj=0.964) at a four-momentum transfer squared, Q2=0.665 (GeV/c)2 (ω=0.368 GeV, W=2.057 GeV), and for recoil momenta up to 550 MeV/c. deviates by 1–2σ from state-of-the-art calculation low momenta. At high is well described same calculation; however, this region, final-state interactions interaction currents are predicted be large, alternative choices...
Exclusive electroproduction of pi0 mesons on protons in the backward hemisphere has been studied at Q**2 = 1.0 GeV**2 by detecting forward direction coincidence with scattered electrons from 4 GeV electron beam Jefferson Lab's Hall A. The data span range total (gamma* p) center-of-mass energy W pion production threshold to 2.0 GeV. differential cross sections sigma_T+epsilon*sigma_L, sigma_TL, and sigma_TT were separated azimuthal distribution are presented together MAID SAID parametrizations.
The ${}^{12}\mathrm{C}(\ensuremath{\gamma},np)$ and ${}^{12}\mathrm{C}(\ensuremath{\gamma},pp)$ reactions have been studied using the Glasgow photon tagging spectrometer at Mainz MAMI electron microtron for ${E}_{\ensuremath{\gamma}}=150--700$ MeV over a kinematic range which extends well beyond approximately back-to-back detector arrangements of previous work. For general trends missing energy distributions are reproduced wide kinematics energies by theory developed Valencia group....
Results are presented from a coincidence study of the $^{12}\mathrm{C}(\ensuremath{\gamma}, {\ensuremath{\pi}}^{+}n)^{11}\mathrm{B}$ quasifree pion production reaction made in $\ensuremath{\Delta}$-resonance region using tagged photons. Cross sections for reactions originating on $1p$-shell protons found to be significantly larger than predicted by calculations based production. It is suggested that more sophisticated calculations, perhaps including medium effects, may required reproduce data.
We measured the cross section and response functions (R_L, R_T, R_LT) for 16O(e,e'p) reaction in quasielastic kinematics missing energies 25 <= E_miss 120 MeV at various momenta P_miss 340 MeV/c. For < 50 \approx 60 MeV/c, is dominated by single-nucleon knockout from 1s1/2-state. At larger P_miss, single-particle aspects are increasingly masked more complicated processes. > 200 relatively constant. Calculations which include contributions pion exchange currents, isobar currents...
Cross sections have been measured for the ${}^{209}\mathrm{Bi}{(e,e}^{\ensuremath{'}}{p)}^{208}\mathrm{Pb}$ and ${}^{209}\mathrm{Bi}(\ensuremath{\gamma}{,p)}^{208}\mathrm{Pb}$ reactions using electrons at ${E}_{e}=293$ 412 MeV, tagged photons mean ${E}_{\ensuremath{\gamma}}\ensuremath{\sim}43.7$ $\ensuremath{\sim}52.0$ respectively. The results are compared to complete distorted wave impulse approximation calculations, from which it is deduced that a model of ${}^{209}\mathrm{Bi}$ based on...
A measurement of the 12C(γ,π+n)11B reaction in quasifree π-production kinematic regimes has been performed using tagged photons conjunction with large solid angle π and n detectors. The aim experiment was to investigate predicted modifications Δ excitation nucleons their subsequent propagation decay, brought about by nuclear medium. Differential cross sections are presented for photon energies spanning Δ(1232) region. measurements consistent distorted wave impulse approximation calculations...
We have made the first measurements of virtual Compton scattering (VCS) process via $\mathrm{H}$($e$, ${e}^{'}p$)$\ensuremath{\gamma}$ exclusive reaction in nucleon resonance region, at backward angles. Results are presented for $W$-dependence fixed ${Q}^{2}=1 {\mathrm{GeV}}^{2}$ and ${Q}^{2}$ dependence $W$ near 1.5 GeV. The VCS data show resonant structures second regions. observed is smooth. measured ratio to ${e}^{'}p$)${\ensuremath{\pi}}^{0}$ cross sections emphasizes different...
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The ${}^{12}\mathrm{C}(\ensuremath{\gamma},pd)$ reaction has been studied for photon energies between 150 and 400 MeV using the Glasgow tagging spectrometer plastic scintillator detectors at Mainz MAMI electron accelerator. overall energy resolution was $\ensuremath{\sim}6$ MeV, sufficient to determine initial shells of emitted nucleons. dependence cross section missing recoil momentum spectra indicate that, low residual excitation, proceeds through interaction with three detected nucleons...