A5084097638- Cardiac Arrest and Resuscitation
- Family and Patient Care in Intensive Care Units
- Digital Mental Health Interventions
- Intensive Care Unit Cognitive Disorders
- Mental Health Research Topics
- Traumatic Brain Injury and Neurovascular Disturbances
- Palliative Care and End-of-Life Issues
- Traumatic Brain Injury Research
- Patient-Provider Communication in Healthcare
- Impact of Technology on Adolescents
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- COVID-19 and Mental Health
- Empathy and Medical Education
- Heart Failure Treatment and Management
- Long-Term Effects of COVID-19
- Child and Adolescent Psychosocial and Emotional Development
- Healthcare Decision-Making and Restraints
- Psychological Testing and Assessment
- Medication Adherence and Compliance
- Ethics in medical practice
- Mental Health Treatment and Access
- Ethics and Legal Issues in Pediatric Healthcare
- Frailty in Older Adults
- Simulation-Based Education in Healthcare
- Maternal Mental Health During Pregnancy and Postpartum
University Hospital of Basel
2020-2022
University of Basel
2021-2022
University of Bern
2016-2020
Background Internet-based cognitive–behavioural treatment (ICBT) for anxiety disorders has shown some promise, but no study yet examined unguided ICBT in primary care. This randomized controlled trial (RCT) investigated whether a transdiagnostic, programme is effective care settings, after face-to-face consultation with physician (MD). We hypothesized that as usual (CAU) plus would be superior to CAU reducing and related symptoms among patients social disorder (SAD), panic or without...
Internet-based cognitive-behavioral treatments (ICBT) have shown promise for various mental disorders, including social anxiety disorder (SAD). Most of these been delivered on desktop computers. However, the use smartphones is becoming ubiquitous and could extend reach ICBT into users' everyday life. Only a few studies empirically examined efficacy through smartphone app there no published study mobile SAD. This three-arm randomized-controlled trial (RCT) first to compare guided (app)...
Background Due to the dramatic measures accompanying isolation and general uncertainty fear associated with COVID-19, patients relatives may be at high risk for adverse psychological outcomes. Until now there has been limited research focusing on prevalence of distress factors in COVID-19 their relatives. The objective our study was assess 30 days after hospital discharge. Methods In this prospective observational cohort two Swiss tertiary-care hospitals we included consecutive adult...
COVID-19 causes psychological distress for patients and their relatives at short term. However, little research addressed the longer-term outcomes in this population. Therefore, we aimed to prospectively assess clinically relevant hospitalized with 90 days after hospital discharge.This exploratory, prospective, observational cohort study included consecutive adult two Swiss tertiary-care hospitals between March June 2020 confirmed relatives. The primary outcome was defined as symptoms of...
Background: Blended cognitive behavioural therapy (bCBT), which combines face-to-face (FtF), and internet-based (iCBT), may be a particularly promising approach, but little is known about the effectiveness patients' subjective evaluations of bCBT format. The aim this qualitative study to explore perceived advantages disadvantages from perspective in specialized mental health care. Methods: Semi-structured interviews were conducted with 15 patients suffering major depression who underwent...
Introduction Intensive care unit patients are at risk for post-intensive syndrome (PICS), which includes psychological, physical and/or cognitive sequelae after their hospital stay. Our aim was to investigate PICS in adult with out-of-hospital cardiac arrest (OHCA). Methods In this prospective observational cohort study, we assessed risks 3 and 12-month follow-up within the following domains: a) impairment (EuroQol [EQ-5D-3L]), b) functioning (Cerebral Performance Category [CPC] score >1,...
Abstract Background A recent study found serum neurofilament light chain (NfL) levels to be strongly associated with poor neurological outcome in patients after cardiac arrest. Our aim was confirm these findings an independent validation and investigate whether NfL improves the prognostic value of two arrest-specific risk scores. Methods This prospective, single-center included 164 consecutive adult out-of-hospital arrest (OHCA) upon intensive care unit admission. We calculated clinical...
Code status discussions are useful for understanding patients’ preferences in the case of a cardiac/pulmonary arrest. These can also provide patients with basis informed decision-making regarding life-sustaining treatment. We conducted survey to understand current practices and perceptions code tertiary-care Swiss hospital.
With the progress in healthcare over recent decades and a growing life expectancy, discussions decisions regarding end-of-life issues have become increasingly important. Especially intensive care emergency medicine there is need of decision making for optimised care. Prolonging preventing death considered to be highest principle professionals; however, some cases alleviation suffering more appropriate goal. This article discusses communication challenges outlines strategies from an area...
Although bedside case presentation contributes to patient-centered care through active patient participation in medical discussions, the complexity of information and jargon-induced confusion may cause misunderstandings discomfort.To compare versus outside room regarding patients' knowledge about their care.Randomized, controlled, parallel-group trial. (ClinicalTrials.gov: NCT03210987).3 Swiss teaching hospitals.Adult patients who were hospitalized.Patients randomly assigned or...
Studies have suggested that taurine may neuro- and cardio-protective functions, but there is little research looking at levels in patients after out-of-hospital cardiac arrest (OHCA). Our aim was to evaluate the association of with mortality neurological deficits a well-defined cohort OHCA patients. We prospectively measured serum concentration upon admission intensive care unit (ICU) University Hospital Basel (Switzerland). analyzed in-hospital (primary endpoint). further evaluated outcomes...
Abstract Objectives Prior research found the gut microbiota-dependent and pro-atherogenic molecule trimethylamine-N-oxide (TMAO) to be associated with cardiovascular events as well all-cause mortality in different patient populations disease. Our aim was investigate prognostic value of TMAO regarding clinical outcomes patients after out-of-hospital cardiac arrest (OHCA). Methods We included consecutive OHCA upon intensive care unit admission into this prospective observational study between...
Activation of the kynurenine pathway (KP) has been shown to predict outcome in cardiac arrest (CA) patients. We validated these findings a Swiss cohort. measured admission tryptophan and levels 270 consecutive CA patients (38 in-hospital CA) investigated associations with mortality neurological at hospital discharge. 120 (44%) died hospital. Compared survivors, non-survivors showed higher median initial (5.28 μmol/l [IQR 2.91 7.40] vs 3.58 2.47 5.46]; p < 0.001) kynurenine/tryptophan ratio...
(1) Background: In patients with shock, the L-arginine nitric oxide pathway is activated, causing an elevation of oxide, asymmetric dimethylarginine (ADMA) and symmetric (SDMA) levels. Whether these metabolites provide prognostic information in after out-of-hospital cardiac arrest (OHCA) remains unclear. (2) Methods: We prospectively included OHCA patients, recorded clinical parameters measured plasma ADMA, SDMA Arginine levels by liquid chromatography tandem mass spectrometry (LC-MS). The...
Internet-Based Cognitive-Behavior Treatment (ICBT) has garnered strong empirical support in the last decade. However, despite growing body of evidence that web-based treatments work, there are still a considerable number clients who do not benefit sufficiently from such interventions. Recently, research started to focus on identifying factors affect treatment outcome and adherence Internet To explore difference between successful versus unsuccessful response ICBT, this article presents two...
There is interest in novel blood markers to improve risk stratification patients presenting with cardiac arrest. We assessed associations of different plasma sphingomyelin concentrations and neurological outcome In this prospective observational study, adult arrest were included upon admission the intensive care unit (ICU). studied levels 15 species at hospital discharge (primary endpoint) defined by modified Rankin Scale calculation univariable multivariable logistic regression models...
Guidelines recommend a ‘do-not-resuscitate’ (DNR) code status for inpatients in which cardiopulmonary resuscitation (CPR) attempts are considered futile because of low probability survival with good neurological outcome. We retrospectively assessed the prevalence DNR and its association presumed CPR futility defined by Good Outcome Following Attempted Resuscitation score Clinical Frailty Scale patients hospitalised Divisions Internal Medicine Traumatology/Orthopedics at University Hospital...
Abstract According to consistency theory, insufficient motive satisfaction (motivational incongruence) is associated with psychological distress and mental disorders. High levels of comorbid disorders are common in patients chronic pain. The aim the present study was investigate role motivational incongruence pain association change symptom improvement. Inpatients multimodal interdisciplinary treatment ( n = 177) completed questionnaires measuring incongruence, distress, intensity...