A5010227320- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Cerebral Venous Sinus Thrombosis
- Ocular Diseases and Behçet’s Syndrome
- Aldose Reductase and Taurine
- Glaucoma and retinal disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Mesenchymal stem cell research
- Ocular Oncology and Treatments
- Retinoids in leukemia and cellular processes
- Protease and Inhibitor Mechanisms
- Melanoma and MAPK Pathways
- Endoplasmic Reticulum Stress and Disease
- Parasite Biology and Host Interactions
- Nerve injury and regeneration
- Parasitic infections in humans and animals
- Neurogenesis and neuroplasticity mechanisms
- Toxoplasma gondii Research Studies
- Renal and Vascular Pathologies
- Flavonoids in Medical Research
- Cell Adhesion Molecules Research
- CRISPR and Genetic Engineering
- Angiogenesis and VEGF in Cancer
Wuhan University
2009-2024
Renmin Hospital of Wuhan University
2009-2024
Shanghai Public Security Bureau
2020
Ophthalmology Associates (United States)
2008
To determine the optimal concentration for inducing differentiation of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) into neuron-like cells, although it is understood that all-trans retinoic acid (ATRA) regulates cell proliferation in nervous system by modulating balance between mitosis and apoptosis.The abilities ATRA to promote apoptosis as well neural were assessed cultured hUC-MSCs morphological observation, MTT assay, annexin V-FITC/PI flow cytometry...
BACKGROUND Glucocorticoids (GCs)-induced glaucoma is a common adverse effect of prolonged GCs use. To better understand the effects on aqueous humor (AH) outflow, we analyzed dataset GSE37474 using bioinformatics analysis to identify gene changes and pathways in anterior segment human eye induced by dexamethasone (DEX). MATERIAL AND METHODS The downloaded from Gene Expression Omnibus (GEO) database was examined this study. GEO2R utilized analyze data differentially expressed genes (DEGs)....
China is currently in a critical stage of controlling the outbreak novel coronavirus pneumonia (COVID-19). As ophthalmologists working center Wuhan city, virus’s front line, we recently found conjunctivitis five COVID-19 patients total 92 patients.One these had as first symptom and was then diagnosed with COVID-19.These observations suggest: mechanism pathway transmission need to be further clarified; symptoms accompanying infection conjunctiva an important entrance point virus verified;...
AIM: To explore the effect of ciliary neurotrophic factor (CNTF) on retinal ganglion cell (RGC)-5 induced by hydrogen peroxide (H2O2). METHODS: After adherence, RGC-5 culture medium was changed to contain different concentrations H2O2 from 50 150 μmol/L at four time points (0.5, 1, 1.5 and 2h) select concentration point for model. Two ways interventions injured cells respectively were CNTF as an addition in or recombinant lentiviral plasmid carrying gene transfecting bone mesenchymal stem...
Abstract Acute retinal ischemia and ischemia-reperfusion injury are the primary causes of neural cell death vision loss in artery occlusion (RAO). The absence an accurate mouse model for simulating ischemic process has hindered progress developing neuroprotective agents RAO. We developed a unilateral pterygopalatine ophthalmic (UPOAO) using silicone wire embolization combined with carotid ligation. survival ganglion cells visual function were evaluated to determine duration ischemia....
Acute retinal ischemia and ischemia-reperfusion injury are the primary causes of neural cell death vision loss in artery occlusion (RAO). The absence an accurate mouse model for simulating ischemic process has hindered progress developing neuroprotective agents RAO. We developed a unilateral pterygopalatine ophthalmic (UPOAO) using silicone wire embolization combined with carotid ligation. survival ganglion cells visual function were evaluated to determine duration ischemia....
Acute retinal ischemia and ischemia-reperfusion injury are the primary causes of neural cell death vision loss in artery occlusion (RAO). The absence an accurate mouse model for simulating ischemic process has hindered progress developing neuroprotective agents RAO. We developed a unilateral pterygopalatine ophthalmic (UPOAO) using silicone wire embolization combined with carotid ligation. survival ganglion cells visual function were evaluated to determine duration ischemia....
Acute retinal ischemia and ischemia-reperfusion injury are the primary causes of neural cell death vision loss in artery occlusion (RAO). The absence an accurate mouse model for simulating ischemic process has hindered progress developing neuroprotective agents RAO. We developed a unilateral pterygopalatine ophthalmic (UPOAO) using silicone wire embolization combined with carotid ligation. survival ganglion cells visual function were evaluated to determine duration ischemia....
Diabetic retinopathy (DR) is one of the most common complications diabetic microvascular disease and its pathogenesis complicated. The PI3k/Akt signaling pathway plays an important role in angiogenesis DR.To explore molecular mechanisms ACO3 protein related proteins DR, order to provide a scientific theoretical basis for clinical treatment this disease.A DR rat model was used study. One group (anti-ACO3 group, n = 10) injected with antagonist; 2nd study (the same amount normal saline;...
<i>Purpose:</i> To report the occurrence of an astrocytoma ciliary body. <i>Methods:</i> The patient was evaluated by ophthalmoscopic examination (including color ultrasonography and ultrasound biomicroscopy) as well operating therapy. Histopathology immunocytochemical analysis were performed. <i>Results:</i> A 29-year-old woman found to have a left body tumor. Color revealed 12 × 10 mm size, low-level echo boundary, bright echogenic band. Ultrasound...
2019新型冠状病毒感染相关死亡的尸体检验2例及现场防护经验.摘 要：.法医病理学；新型冠状病毒肺炎；现场勘验；尸体检验；安全防护.
Background Intravitreal injection of triamcinolone acetonide (TA) can effectively eliminate central vein occlusion macular edema and improve visual acuity, photopic negative response (PhNR) reflect the inner retinal function RGCs their axons. It is possible there a correlation between these two observations.Objective This study was to evaluate changes PhNR flash electroretinogram (F-ERG) after intravitreal TA for in ( CRVO ). Methods Thirteen eyes 12 patients with caused by received an 0. 1...
Objective To investigate the experimental condition and mechanism of differentiation human umbilical cord blood derived mesenchymal stem cells(hUCB-MSC)into neuron-like cells induced by recombined epidermal growth factor (rhEGF) taurine in vitro.Methods hUCB-MSC were primary cultured Dulbecco's modified Eagle's medium/F-12 (DMEM/F-12)which supplemented with 105U/L penicillin G,100 mg/L streptomycin sulfate,10% fetal bovine serum (FBS),5% autologous plasma,4 mmol L-glutamine,30 ng/ml...