A5101538950- Retinal Development and Disorders
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Retinal Diseases and Treatments
- Ocular Oncology and Treatments
- Angiogenesis and VEGF in Cancer
- Ophthalmology and Visual Impairment Studies
- Cell Adhesion Molecules Research
- Corneal Surgery and Treatments
- Ocular Disorders and Treatments
- Nitric Oxide and Endothelin Effects
- S100 Proteins and Annexins
- Autophagy in Disease and Therapy
- Galectins and Cancer Biology
- Adenosine and Purinergic Signaling
- Retinoids in leukemia and cellular processes
- NF-κB Signaling Pathways
- Corneal surgery and disorders
- Glaucoma and retinal disorders
- RNA modifications and cancer
- Ocular Diseases and Behçet’s Syndrome
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer, Hypoxia, and Metabolism
- Cell death mechanisms and regulation
- Cancer-related Molecular Pathways
Wuhan University
2016-2025
Renmin Hospital of Wuhan University
2016-2025
Wuhan Sports University
2014
Purpose: N6-methyladenosine (m6A) modification has been implicated in ischemia–reperfusion injury various systems and several neurodegenerative diseases. Glaucoma is characterized by degeneration of retinal ganglion cells (RGCs) shares similar pathologic characteristics with (RIR) injury. However, the specific role m6A RIR unclear, involvement autophagy also remains controversial. Therefore, our study explored Methods: Male wild-type C57BL/6J mice (6–8 weeks old) were used to induce Retinal...
Herpes simplex virus type-1-induced herpes keratitis (HSK) is a common immunological cornea disease. While previous studies have addressed the role of tumor necrosis factor (TNF)-α and matrix metalloproteinases (MMPs) in HSK, mechanistic link between TNF-α MMPs pathogenesis HSK remains elusive.We first established mice model measured levels TNF-α, MMP-2 MMP-9 corneas at different time points by ELISA. Next, we employed cultured human corneal epithelial (HCE) cells as an vitro performed...
The expression patterns and functional roles of miRNAs in Retinoblastoma (RB) is poorly understood, especially these involved chemoresistance. Here, we validated the pattern 20 potential RB-suppressive confirmed that miR-184 most significantly decreased miRNA human RB tissues, as well chemoresistant cell line. Bioinformatic molecular analysis revealed SLC7A5 has three binding sites increased tissues. negatively correlated with tissues mainly target position 2494-2513 3’UTR to inhibit its...
To detect variants in 17 known potentially causative genes for non-syndromic myopia 67 Tujia Chinese patients with early-onset high (eo-HM).DNA from unrelated early onset (<7 years old) (refraction error ≤ -6.00D or axial length > 26 mm) were subjected to whole-exome sequencing (WES). Variants candidate analysed by multistep bioinformatics analysis. Subsequently, Sanger was used verify identified mutations and assess available family members co-segregation myopia.A systematic analysis of...
In this study, a homogeneous polysaccharide (ATP-II), with molecular weight of 3.4 × 10(4) Da, was successfully purified from Aster tataricus by DEAE-Sepharose CL-6B ion exchange and Sepharose gel filtration chromatography. Monosaccharide component analysis indicated that ATP-II composed glucose, galactose, mannose, rhamnose, arabinose in molar ratios 2.1:5.2:2.1:1.0:1.2. We evaluated the anticancer efficacy associated mechanisms on glioma C6 cells vitro vivo. The results showed treatment...
The purpose of the present study was to investigate role paxillin in vascular endothelial growth factor A (VEGF‑A)‑induced adhesion, proliferation, migration and capillary formation cells (ECs) vitro. Human umbilical vein ECs (HUVECs) were used evaluate these four processes HUVECs either mock‑transfected (control), transfected with scramble small interference RNA (siRNA) or siRNA specifically targeting paxillin. VEGF‑A (20 ng/ml) stimulate angiogenesis. treatment significantly increased tube...
Background . The objective of this study is to determine optic nerve head vascular changes in patients with obstructive sleep apnea‐hypopnea syndrome (OSAS) by utilizing an optical coherence tomography angiography (OCTA) device. Methods A detailed studies search was screened the PubMed, Embase, Cochrane Library, and Web Science databases from inception August 2023. We reviewed examined density eyes OSAS controls. mean difference 95% confidence interval were calculated evaluate continuous...
Galectin-1 (Gal-1) has been proved to be an important factor in the process of tumor angiogenesis recently. As a small molecule, OTX008 serves as selective inhibitor Gal-1. In this study, role Gal-1 and antiangiogenic effect on retinal neovascularization (RNV) were investigated using mouse model oxygen-induced retinopathy. The outcome indicated that was overexpressed closely related neovessels OIR. After intravitreal injection at P12, RNV significantly reduced P17, measuring by...