A5030350968- Scoliosis diagnosis and treatment
- Bone health and osteoporosis research
- Connective tissue disorders research
- Hip disorders and treatments
- Body Composition Measurement Techniques
- Bone fractures and treatments
- Biomarkers in Disease Mechanisms
- Pelvic and Acetabular Injuries
- Myofascial pain diagnosis and treatment
- Nutrition and Health in Aging
- Spondyloarthritis Studies and Treatments
- Bone Metabolism and Diseases
- Medical Imaging and Analysis
- Hip and Femur Fractures
- Effects of Vibration on Health
- Medical Imaging Techniques and Applications
- Cardiovascular Health and Disease Prevention
- TGF-β signaling in diseases
- Advanced X-ray and CT Imaging
- Diet and metabolism studies
- Shoulder Injury and Treatment
- Forensic Anthropology and Bioarchaeology Studies
- Occupational Health and Safety Research
- Vitamin D Research Studies
- Lymphatic System and Diseases
Chinese University of Hong Kong
2014-2023
Prince of Wales Hospital
2016-2017
Nanjing University
2014-2016
Adolescent idiopathic scoliosis (AIS) is a prevalent spinal deformity occurring during peripubertal growth period that affects 1‐4% of adolescents globally without clear etiopathogenetic mechanism. Low bone mineral density an independent and significant prognostic factor for curve progression. Currently, the cause underlying low mass in AIS remains elusive. Osteocytes play important role metabolism homeostasis, but its has not been studied. In present study, iliac tissues were harvested from...
Abstract Adolescent idiopathic scoliosis is a complex disease with unclear etiopathogenesis. Systemic and persistent low bone mineral density an independent prognostic factor for curve progression. The fundamental question of how quality affected in AIS remains controversy because there lack site-matched control detailed analysis on bone-related parameters. In this case-control study, trabecular biopsies from iliac crest were collected intra-operatively 28 severe patients 10 matched controls...
Adolescent idiopathic scoliosis (AIS) patients have lower physical activity levels than normal adolescents, and there is an association with poorer bone muscle health. This study evaluated the effects of a home-based exercise intervention (E-Fit) on mineral density (BMD), function, quality life (QoL) in AIS-affected girls. A total 40 AIS females aged 11 to 14 years were randomly assigned E-Fit or control group. The group performed modified 7-min high-intensity interval training (HIIT) 5 days...
ABSTRACT Distal forearm fractures during growth are more common in males than females. Because metaphyseal cortical bone is formed by coalescence of trabeculae emerging from the periphery plate, we hypothesized that later onset puberty produces a longer delay trabecular formation and coalescence, which leaves transient phase high porosity, low matrix mineral density, density relative to We quantified nondominant distal radial microstructure using high-resolution peripheral quantitative...
Abstract Bone densitometry revealed low bone mass in patients with adolescent idiopathic scoliosis (AIS) and its prognostic potential to predict curve progression. Recent studies showed differential circulating miRNAs AIS but their diagnostic links have not been well-documented. The present study aimed compare miRNA profiles tissues collected from non-scoliotic subjects, explore if the selected candidates could be useful biomarkers for AIS. Microarray analysis identified miR-96-5p being most...
Results Compared with controls, AIS subjects had higher sOB-R level (p=0.006), SMI value (p=0.020) reflecting more rod-like structures within the trabecular compartment, and numerically lower stiffness (-2.03%) estimated failure load (-3.07%). Significant negative correlation was found between serum total leptin in (r=-0.325; p=0.003) but not controls (p=0.533). positive correlations were stiffness, load, both (r=0.278, p=0.003; r=0.268, p=0.004 respectively) (r=0.462, p<0.001; r=0.468,...
Adolescent idiopathic scoliosis (AIS) is characterized by deranged bone and muscle qualities, which are important prognostic factors for curve progression. This retrospective case-control study aims to investigate whether the baseline parameters, in addition could predict progression AIS.The included a cohort of 126 female patients diagnosed with AIS who were between ages 12 14 years old at their initial clinical visit. These longitudinally followed up every 6 months (average 4.08 years)...
ObjectivesAlthough AIS was associated with low bone mass, reports on mechanical properties in are sparse.The objective of this study is to evaluate finite element analysis (FEA) using in-vivo High-Resolution Peripheral Quantitative Computed Tomography (HR-pQCT) and compare that normal controls.
Multiple studies have documented the presence of systemic osteopenia in AIS.Osteopenia was associated with severe curves and reported to be one significant prognostic factors for curve progression AIS.This study aimed evaluate bone quality strength parameters including rod-plate configuration finite element analysis (FEA) vivo High-Resolution Peripheral Quantitative Computed Tomography (HR-pQCT) investigate their relationship AIS Vs normal controls.