John M. Sykes

ORCID: 0000-0001-7444-3187
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About
Contact & Profiles
Research Areas
  • Turtle Biology and Conservation
  • Amphibian and Reptile Biology
  • Animal Virus Infections Studies
  • Rabies epidemiology and control
  • Veterinary Pharmacology and Anesthesia
  • Bird parasitology and diseases
  • SARS-CoV-2 and COVID-19 Research
  • Veterinary Oncology Research
  • Poxvirus research and outbreaks
  • Ocular Infections and Treatments
  • Antibiotics Pharmacokinetics and Efficacy
  • Aquaculture disease management and microbiota
  • COVID-19 Clinical Research Studies
  • Leptospirosis research and findings
  • Zoonotic diseases and public health
  • Microbial infections and disease research
  • Oral and Maxillofacial Pathology
  • Virus-based gene therapy research
  • Viral Infections and Vectors
  • Salmonella and Campylobacter epidemiology
  • Animal Ecology and Behavior Studies
  • Venomous Animal Envenomation and Studies
  • Pediatric Pain Management Techniques
  • Marine animal studies overview
  • Bartonella species infections research

Wildlife Conservation Society
2010-2023

The Bronx Defenders
2022

United States Department of Agriculture
2021

University of Illinois Urbana-Champaign
2021

New York State College of Veterinary Medicine
2021

Cornell University
2021

Chicago Zoological Society
2021

Columbia University Irving Medical Center
2020

Wildlife Conservation Society United Kingdom
2016

University of Tennessee at Knoxville
2006-2009

The human-animal-environment interface of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important aspect the disease 2019 (COVID-19) pandemic that requires robust One Health-based investigations. Despite this, few reports describe natural infections in animals or directly link them to human using genomic data. In present study, we first cases SARS-CoV-2 infection tigers and lions United States provide epidemiological genetic evidence for human-to-animal transmission...

10.1128/mbio.02220-20 article EN cc-by mBio 2020-10-12

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged as the cause of a global pandemic in 2019–2020. In March 2020, New York City became epicenter United States for pandemic. On 27 Malayan tiger (Panthera tigris jacksoni) at Bronx Zoo developed cough and wheezing with subsequent inappetence. Over next week, an additional two Amur tigers altaica) same building three lions leo krugeri) separate also ill. The index case was anesthetized diagnostic workup. Physical examination...

10.1638/2020-0171 article EN Journal of Zoo and Wildlife Medicine 2021-01-12

A retrospective study of neoplasia in reptiles held at the Philadelphia Zoological Garden was conducted. total 3,684 original necropsy reports for period 1901–2002 were reviewed and revealed 86 cases neoplasia. Original glass slides or re-cuts from paraffin-embedded tissue blocks examined confirmation diagnosis. At necropsy, a six neoplasms identified 490 chelonians (1.2%), 22 19 736 lizards (3.0%), 58 53 1,835 snakes (2.9%). An additional 12 found biopsies one turtle 10 snakes. In...

10.1638/04-112.1 article EN Journal of Zoo and Wildlife Medicine 2006-03-01

Abstract We describe the first cases of natural SARS-CoV-2 infection detected in animals United States. In March 2020, four tigers and three lions at Bronx Zoo developed mild respiratory signs. RNA was by rRT-PCR secretions and/or feces from all seven affected animals; viral antibodies were their keepers. isolated or situ hybridization co-localized with cellular damage. Whole genome sequence haplotype network analyses showed infected two different strains, suggesting independent...

10.1101/2020.07.22.213959 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2020-07-23

OBJECTIVE To identify important subspecies and serovars of Salmonella enterica in a captive reptile population clinically relevant risk factors for signs illness Salmonella-positive reptiles. DESIGN Retrospective cross-sectional study. ANIMALS 11 crocodilians (4 samples), 78 snakes (91 59 lizards (57 34 chelonians (23 samples) at the Bronx Zoo from 2000 through 2012. PROCEDURES Data pertaining to various types biological samples obtained reptiles with positive culture results themselves were...

10.2460/javma.248.9.1050 article EN Journal of the American Veterinary Medical Association 2016-04-13

Although recognized as a potential complication after endotracheal intubation in birds, the rate of postintubation tracheal obstruction this taxon is unknown. Twenty-three cases birds from two institutions are reported. Clinical signs were noted an average 16.6 days and consisted primarily indications acute respiratory distress. Diagnosis was confirmed via tracheoscopy or radiology. Five died before treatment could be initiated. Medical alone successful three that had mild changes consisting...

10.1638/2012-0291r.1 article EN Journal of Zoo and Wildlife Medicine 2013-09-01

A review of avian cataracts at the Wildlife Conservation Society's Bronx Zoo between 1992 and 2011 was conducted. Ninety in 54 birds from 42 species were identified. Cataracts found primarily during examination for ocular abnormalities (29/54, 53.7%) or opportunistically (13/54, 24.1%) most commonly diagnosed as mature (22/90, 24.4%). Systemic medical conditions these included West Nile virus (4/54, 7.4%), head trauma (3/54, 5.6%), plumbism Salmonella Pullorum (1/54, 1.9%), Marek's disease...

10.1638/2015-0071.1 article EN Journal of Zoo and Wildlife Medicine 2015-12-01

An adult female Taylor's cantil (Agkistrodon bilineatus taylori) presented with marked spinal and mandibular osteomyelitis that cultured positive for Salmonella enterica subsp. houtenae, serovar IV 43:z4,z32:-. Progression of was arrested by treatment using amikacin (0.026 mg/kg per hour) delivered via subcutaneous osmotic pump 10 mo, replacing the every 4 wk. No adverse effects on renal function were appreciated throughout course therapy. Amikacin therapy discontinued after improvement...

10.1638/2015-0207.1 article EN Journal of Zoo and Wildlife Medicine 2016-06-01

The Bronx River in Bronx, New York, US spans an area of significant human development and has been subject to historic ongoing industrial contamination. We evaluated the health freeranging native common snapping turtles ( Chelydra serpentina) nonnative invasive red-eared sliders Trachemys scripta) a segment between May July 2012. In 18 nine sliders, complete physical examinations were performed, ectoparasites collected, blood was analyzed for contaminants (mercury, thallium, cadmium,...

10.7589/2017-12-304 article EN Journal of Wildlife Diseases 2018-09-18

Vector-borne Plasmodium spp. infect a wide range of bird species. Although infections may be asymptomatic, certain genera, especially those that evolved in regions without endemic malaria, appear particularly susceptible to symptomatic disease, leading morbidity and mortality. High mortalities associated with malaria have been documented captive species Sphenisciformes, Somateria, Larosterna, all genera climates low mosquito exposure. To better characterize trends Plasmodium-related...

10.1638/2019-0078 article EN Journal of Zoo and Wildlife Medicine 2020-03-17

Snake fungal disease (SFD; Ophidiomyces ophiodiicola) is posing a significant threat to several free-ranging populations of pitvipers. Triazole antifungals have been proposed for the treatment mycoses in reptiles; however, data are lacking about their safety and efficacy snakes with SFD. Study 1 investigated vitro susceptibility, identified that plasma concentrations >250 ng/ml (voriconazole) >1,000 (itraconazole) may be effective vivo In 2, pharmacokinetics after single subcutaneous...

10.1638/2016-0179.1 article EN Journal of Zoo and Wildlife Medicine 2017-09-01

To determine pharmacokinetics of butorphanol delivered via osmotic pumps in common peafowl (Pavo cristatus) as a method for analgesic administration to avian species.14 healthy adult male peafowl.A preliminary experiment was conducted with 2 birds establish time point and concentration requirements. Then, the remaining 12 were anesthetized, containing (volume, mL; mean dosage, 247 μg/kg/h) implanted subcutaneously each bird 7 days prior removal. Blood samples collected before pump...

10.2460/ajvr.76.12.1070 article EN American Journal of Veterinary Research 2015-11-30

10.1053/j.jepm.2006.06.007 article EN Journal of Exotic Pet Medicine 2006-07-01

The risk of accidental envenomation to the handler venomous snakes during drug administration limits ability treat these animals. One commercially available osmotic pump is a miniature self-contained cylindrical implant that operates on basis an pressure difference between extracellular fluid and agent in pump. Osmotic pumps loaded with amikacin were surgically placed into coelomic cavity five adult corn (Elaphe guttata guttata) (group A). Four B) received intramuscular injection at 5 mg/kg...

10.1638/05-057-tym-122705.1 article EN Journal of Zoo and Wildlife Medicine 2006-09-01

Oral eosinophilic granulomas were diagnosed in 16 tigers (Panthera tigris). All lesions located on the hard or soft palate and typically consisted of flat slightly raised circular ulcers. Histologic features these essentially identical to those seen oral domestic cats dogs. No clinical signs noted eight cases, though various degrees inappetence, excessive salivation, dysphagia other tigers. Six cases not treated. Treatment for remaining 10 centered corticosteroids additional treatments...

10.1638/1042-7260(2007)038[0300:oegitp]2.0.co;2 article EN Journal of Zoo and Wildlife Medicine 2007-06-01

The efficacy of three radiopharmaceuticals, 99m Tc‐diethylenetriaminepentaacetic acid ( Tc‐DTPA), Tc‐dimercaptosuccinic Tc‐DMSA), and Tc‐mercaptoacetyltriglycine Tc‐MAG 3 ), for renal imaging was examined in 16 corn snakes Elaphe guttata ). All received the radiopharmaceutical via an intracardiac injection. kidneys could not be visualized that Tc‐DTPA or Tc‐DMSA, but were well delineated all 10 receiving . These anesthetized a dynamic frame mode acquisition obtained 30 min immediately...

10.1111/j.1740-8261.2006.00131.x article EN Veterinary Radiology & Ultrasound 2006-03-01

Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) emerged as the cause of a global pandemic in 2019-2020. In March 2020 New York City became USA epicenter for pandemic. On 27, Malayan tiger ( Panthera tigris jacksoni ) at Bronx Zoo developed cough and wheezing with subsequent inappetence. Over next week, an additional two Amur tigers P. t. altaica same building three lions leo krugeri separate also ill. The index case was immobilized, physical examination bloodwork...

10.1101/2020.08.14.250928 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2020-08-14

An outbreak of dermatophytosis caused by Microsporum canis occurred in tigers (Panthera tigris) at an exotic felid sanctuary 2003. In attempt to find effective, practical, safe, and affordable method for controlling this epizootic, a clinical treatment trial was conducted. Nonalopecic were studied address the inapparent carrier state observed facility. The efficacy three topical environmental combinations 2% lime sulfur solution peroxide-based cleaner evaluated nonalopecic, culture-positive...

10.1638/1042-7260(2007)038[0252:atotpt]2.0.co;2 article EN Journal of Zoo and Wildlife Medicine 2007-06-01
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