A5101782119- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Prostate Cancer Treatment and Research
- Cardiac Imaging and Diagnostics
- Additive Manufacturing and 3D Printing Technologies
- ECG Monitoring and Analysis
- Cancer, Lipids, and Metabolism
- Protein Kinase Regulation and GTPase Signaling
- Cytokine Signaling Pathways and Interactions
- Hedgehog Signaling Pathway Studies
- Congenital Diaphragmatic Hernia Studies
- HIV Research and Treatment
- Cancer-related Molecular Pathways
- Eosinophilic Esophagitis
- Health Systems, Economic Evaluations, Quality of Life
- Melanoma and MAPK Pathways
- Wnt/β-catenin signaling in development and cancer
- RNA Research and Splicing
- Cardiovascular Syncope and Autonomic Disorders
- Organ Donation and Transplantation
- Cancer-related gene regulation
- Genomic variations and chromosomal abnormalities
- Cardiac pacing and defibrillation studies
- Restless Legs Syndrome Research
Memorial Sloan Kettering Cancer Center
2023
Emory University
2013-2022
University of Wisconsin–Madison
2022
Abbott (United States)
2021
Des Moines University
2020
CHI Health
2019
Creighton University
2019
Université de Bordeaux
2018
University of Nevada, Las Vegas
2017-2018
Riverside Community Hospital
2017
To determine if motor restlessness in the Restless Legs Syndrome (RLS) shows a circadian rhythm with maximum at night, as previously found for subjective discomfort and periodic limb movements (PLMs), to correlate RLS peak intensity core temperature cycle. Subjects underwent two days of normally timed wakefulness sleep followed by night subsequent day deprivation. Activity was standardized through modified suggested immobilization tests (mSITs). The study conducted laboratory environment...
Background— A majority of patients undergoing ablation ventricular tachycardia have implanted devices precluding substrate imaging with delayed-enhancement MRI. Contrast-enhanced multidetector computed tomography (MDCT) can depict myocardial wall thickness submillimetric resolution. We evaluated the relationship between regional thinning (WT) imaged by MDCT and arrhythmogenic in postinfarction tachycardia. Methods Results— studied 13 consecutive before ablation. data were integrated...
Heterologous viruses have been examined for their ability to accelerate the course of infection with human immunodeficiency virus (HIV) type 1. In this study, ACH-2 cells persistently infected HIV-1 exhibited augmented replication as a result superinfection herpes simplex (HSV) Using HSV-1 mutants deletions in genes encoding immediate-early proteins ICPO, ICP4, and ICP27, it was found that ICPO but not were essential up-regulation HIV replication. Northern blot analysis showed activation...
Hypothyroidism is a common condition that disproportionately affects hemodialysis patients. In the general population, hypothyroidism associated with higher mortality, particularly in populations underlying cardiovascular risk. Despite their heightened impact of on survival patients remains uncertain. To examine whether independently mortality Among 8840 incident receiving care from large national dialysis provider January 2007 to December 2011, we examined association (TSH >5.0 mIU/L)...
Abstract The androgen receptor (AR) is a member of unique class transcription factors because it contains ligand-binding domain that, when activated, results in nuclear translocation and the transcriptional activation genes associated with prostate cancer development. Although deprivation therapies are effective initially for treatment cancer, disease eventually relapses progresses to castration-resistant (CRPC). Nonetheless, AR still plays critical role late-stage investigational agents...
Epicardial adipose tissue (EAT) has been described in the general population as an independent risk marker for incident coronary artery disease. In hemodialysis patients, it correlates with other markers of cardiovascular disease, but is unknown if associated adverse events.post hoc analysis Renagel New Dialysis (RIND) patients study, a randomized trial sevelamer versus calcium-based phosphate binders 109 followed all-cause mortality median 49.3 months. Patients underwent baseline cardiac...
Background— Radiofrequency ablation for ventricular arrhythmias is limited by inability to visualize tissue destruction, reversible conduction block resulting from edema surrounding lesions, and insufficient lesion depth. We hypothesized that transcatheter needle injection of caustic agents doped with gadolinium contrast under real-time magnetic resonance imaging (MRI) could achieve deep, targeted, irreversible myocardial ablation, which would be immediately visible. Methods Results— Under...
Renal replacement therapy was an early pioneer in both extra-corporeal organ and whole transplantation. Today, the success of this pioneering work is directly demonstrated millions patients worldwide successfully treated with dialysis kidney However, there remain significant shortcomings to current treatment modalities that limit clinical outcomes quality life. To address these problems, researchers have turned using cell-based therapies for development a bioartificial kidney. These...
Interferons (IFNs) exert antiproliferative effects on many types of cells. The underlying molecular mechanism, however, is unclear. One possibility that IFNs block growth factor-induced mitogenic signaling, which involves activation Ras/Raf-1/MEK/mitogen-activated protein kinase. We have tested this hypothesis by using HER14 cells (NIH 3T3 cell expressing both platelet-derived factor [PDGF] and epidermal [EGF] receptors) as a model system. Our studies showed (alpha/beta gamma) blocked...
The risk of thrombosis in individuals with rare compound thrombophilias, homozygous factor V Leiden (FVL) plus heterozygous prothrombin G20210A (PTM), PTM FVL, and FVL PTM, is unknown. We identified, worldwide, these predominantly through mailing members the International Society on Thrombosis Haemostasis. Physicians were sent a clinical questionnaire. Confirmatory copies genetic results obtained. One hundred enrolled; 58% female. Seventy-one had venous (includes superficial deep vein...
Conduction velocity (CV) heterogeneity and myocardial fibrosis both promote re-entry, but the relationship between as determined by left atrial (LA) late-gadolinium enhanced cardiac magnetic resonance imaging (LGE-CMRI) CV remains uncertain.Although average has been shown to correlate with regional LGE-CMRI in patients persistent AF, we test hypothesis that a localized exists underpin minimally invasive tool map conduction properties for risk stratification treatment guidance.3D LA...
Background: The majority of data regarding tissue substrate for post myocardial infarction (MI) VT has been collected during hemodynamically tolerated VT, which may be distinct from the responsible with hemodynamic compromise (VT-HC). This study aimed to characterize at diastolic locations VT-HC in a porcine model. Methods: Late Gadolinium Enhancement (LGE) cardiovascular magnetic resonance (CMR) imaging was performed eight pigs healed antero-septal infarcts. Seven underwent...
Interferons (IFNs) exert antiproliferative effects on many types of cells. The underlying molecular mechanism, however, is unclear. One possibility that IFNs block growth factor-induced mitogenic signaling, which involves activation Ras/Raf-1/MEK/mitogen-activated protein kinase. We have tested this hypothesis by using HER14 cells (NIH 3T3 cell expressing both platelet-derived factor [PDGF] and epidermal [EGF] receptors) as a model system. Our studies showed (alpha/beta gamma) blocked...
This study sought to determine the contribution of self-inflicted injury-related deaths local organ donation rates and analyze contributing factors.A retrospective review adult patients with traumatic injuries was performed at a Level I trauma center from 2013 2017. Data were obtained institutional registry cross-referenced procurement organization (OPO). Referral analyzed outcomes, demographics injury characteristics compared between who underwent versus those did not.142 presented injury,...