A5033595772- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Transplantation Techniques and Outcomes
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Nutrition and Health in Aging
- Cancer Immunotherapy and Biomarkers
- Hepatitis C virus research
- Pancreatic and Hepatic Oncology Research
- Immune cells in cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Atherosclerosis and Cardiovascular Diseases
- Adenosine and Purinergic Signaling
- Hepatitis B Virus Studies
- Diverticular Disease and Complications
- Pancreatitis Pathology and Treatment
- Macrophage Migration Inhibitory Factor
- Palliative Care and End-of-Life Issues
- Immunotherapy and Immune Responses
- Genital Health and Disease
- Dysphagia Assessment and Management
- Cervical Cancer and HPV Research
- Colorectal Cancer Surgical Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
University Hospitals Birmingham NHS Foundation Trust
2019-2024
University of Birmingham
2018-2023
Queen Elizabeth Hospital Birmingham
2017-2022
Queen Elizabeth Hospital
2020
NIHR Birmingham Liver Biomedical Research Unit
2018-2020
National Institute for Health Research
2020
NIHR Birmingham Biomedical Research Centre
2019-2020
TriNetX (United States)
2020
Nanjing Medical University
2019
Ormskirk District General Hospital
2013
Objective: The aim of this study was to investigate tumor recurrence after liver transplantation for hepatocellular carcinoma (HCC), with and without hypothermic oxygenated perfusion (HOPE) before transplantation. Patients Methods: We analyzed all recipients HCC, transplanted between January 2012 September 2019 donation circulatory death (DCD) livers previous end-ischemic HOPE-treatment (n = 70, Center A). Tumor parameters key confounders were compared consecutive during the same observation...
Treatment of hepatocellular carcinoma (HCC) is predicated on early diagnosis such that 'curative therapies' can be successfully applied. The term 'curative' is, however, poorly quantitated. We aimed to complement our previous work by developing a statistical model predict cure after ablation and use this analysis compare the true curative potential various therapies.
Abstract Background Advanced hepatocellular carcinoma (HCC) is commonly diagnosed using non-invasive radiological criteria (NIRC) defined by the European Association for Study of Liver or American Diseases. In 2017, The National Institute Clinical Excellence mandated histological confirmation disease to authorise use sorafenib in UK. Methods This was a prospective multicentre audit which patients suitable were identified at multidisciplinary meetings. primary analysis cohort (PAC) presence...
Abstract Background Access to the liver transplant waitlist for patients with hepatocellular carcinoma (HCC) depends on tumour presentation, biology, and response treatments. The Milan Criteria (MC) represent benchmark expanded criteria that incorporate additional prognostic factors. purpose of this study was determine added value skeletal muscle index (SMI) in HCC beyond MC. Method Patients were transplanted MC included retrospective multicentre study. SMI quantified using Computed...
Bleeding from parastomal varices causes significant morbidity and mortality. Treatment options are limited, particularly in high-risk patients with underlying liver disease other comorbidities. The use of EUS-guided embolisation coils combined thrombin injection gastric has been shown to be safe effective. Our institution applied the same technique treatment varices.A retrospective review was performed 37 procedures on 24 assess efficacy safety thrombin, or without for bleeding varices. All...
OBJECTIVE--To determine whether interferon alpha-2a, when utilised as adjuvant chemotherapy following ablation of condylomata acuminata (genital warts) by cryotherapy, is effective in the prevention recurrences. DESIGN--Randomised, placebo-controlled, double-blind study. Statistical analysis was 2-tailed Fisher9s Exact Test. PATIENTS--97 patients with recurrent acuminata. INTERVENTION--49 were treated cryotherapy plus subcutaneously administered and 48 received placebo. Of these, 36 37...
Scavenger receptor class F member 1 (SCARF1) is thought to play an important role in the selective recruitment of CD4+ T cells liver sinusoidal endothelial during chronic disease. However, contribution SCARF1 hepatocellular carcinoma (HCC) currently unknown. We utilized publically-available RNA-sequencing data from The Cancer Genome Atlas (TGCA) explore expression HCC and correlated it with a number clinicopathological features. Flow adhesion assays were used determine cell subset...
Background. There is a lack of data on the use direct-acting antivirals (DAA) risk death and tumoral recurrence in patients with hepatitis C virus (HCV) hepatocellular carcinoma (HCC) listed for liver transplantation (LT). We aimed to assess impact antiviral treatment mortality HCC HCC-HCV. Methods. This was retrospective multicenter study HCC-HCV LT from 2005 2015. Patients were divided according received after diagnosis: DAA, interferon (IFN), or no antiviral. Intention-to-treat overall...
Ascites is well-documented sequelae of liver cirrhosis with significant impact on survival in this group patients. Among the many established management strategies for same use an implantable mechanical device, called alfapump® (Sequana Medical, Zurich, Switzerland), that removes ascitic fluid by pumping it from peritoneal cavity to urinary bladder. Until recently, device has been surgically placed under general anaesthesia. We describe successful interventional radiological implantation...
This case was rather unusual with regard to the disease presentation. The patient had non-specific symptoms of weight loss and general malaise, without any history preceding diarrhoea or dysentery. It is important be aware epidemiology disease, relate it patients presenting suggestive amoebiasis. We discuss recommended investigations management options for these based on current guidelines/evidence.
<h3>Introduction</h3> Gastric varices are present in 5%–33% of patients with portal hypertension incidence bleeding around 25% 2 years.<sup>1</sup> If gastric identified as the source bleeding, therapeutic options include endoscopic Methods, TIPSS, surgery and non-selective beta blockade.<sup>2</sup> There reports EUS guided coiling combined cyanoacrylate glue<sup>3</sup> but limited literature on safety efficacy coil embolisation human thrombin injection. We report our experience....
Purpose: Patients with unexplained weight loss as their main presenting symptom referred to gastroenterology, or without other GI symptoms, often undergo multiple investigations exclude occult malignancy. This study assessed the diagnostic yield of CT scans in identifying malignancy cause. Methods: is a retrospective analysis consecutive requested from gastroenterology clinics for spontaneous over 12-month period. previously diagnosed and those undergoing staging were excluded analysis....
Hepatocellular carcinoma (HCC) is the most common primary liver cancer, with increasing prevalence and mortality worldwide. The greatest risk factor for HCC cirrhosis; however, these patients are often asymptomatic, making them difficult to identify surveillance. Diagnosis made contrast-enhanced imaging and/or biopsy. assessed validated Barcelona Clinic Liver Cancer staging system, which encompasses tumour size, function patient performance status. without extrahepatic manifestations or...
<h3>Introduction</h3> Recurrent bleeding from stomal varices secondary to portal hypertension can be challenging treat. Treatments available include transjugular intrahepatic portosystemic shunt (TIPSS) and/or coil embolisation of the dominant vein passing stoma or surgical formation.<sup>1</sup> A more recent approach treat gastric is using endoscopic ultrasound (EUS) guidance in combination with cyanoacrylate glue.<sup>2</sup> Endoscopic use human thrombin has also been proposed as a...
<h3>Introduction</h3> Experts are able to predict and differentiate between neoplastic non-neoplastic colonic polyps with high accuracy meet the PIVI (Preservation Incorporation of Valuable Endoscopic Innovations) thresholds. However, this has not been replicated in non-experts cannot be currently recommended clinical practice. The aim randomised trial was establish optimum method training increase diagnostic diminutive/small polyp histological prediction by trainee gastroenterologists....