A5034845812- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Sarcoma Diagnosis and Treatment
- Esophageal and GI Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- Pancreatitis Pathology and Treatment
- Esophageal Cancer Research and Treatment
- Adrenal and Paraganglionic Tumors
- Electrospun Nanofibers in Biomedical Applications
- Gallbladder and Bile Duct Disorders
- Renal cell carcinoma treatment
- Cardiac tumors and thrombi
- Cancer Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Cancer Genomics and Diagnostics
- Central Venous Catheters and Hemodialysis
- 3D Printing in Biomedical Research
- Colorectal Cancer Surgical Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Historical and Archaeological Studies
- Pituitary Gland Disorders and Treatments
Sapienza University of Rome
2016-2025
Azienda Ospedaliera Sant'Andrea
2005-2024
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo
2024
Marche Polytechnic University
2022-2024
Policlinico Umberto I
1998-2022
Università Cattolica del Sacro Cuore
2012-2022
ETH Zurich
2021
Institute of History of Mediterranean Europe
2019-2020
ANT Foundation Italy Onlus
2018
Fox Chase Cancer Center
2017
to evaluate the efficacy and safety of co-micronized palmitoylethanolamide (PEA)/polydatin (PD) in treatment abdominal pain symptoms pediatric patients with Irritable Bowel Syndrome (IBS). The study was a multicenter trial conducted at three Italian gastroenterology centers, employing double-blind, placebo-controlled, parallel-arm design. Participants, aged 10 17 years, met Rome IV criteria for IBS. They were randomly allocated receive either PEA/PD or placebo, administered times daily 1:1...
In this study, we investigated whether multipotent (human-bone-marrow-derived mesenchymal stem cells [hBM-MSCs]) and pluripotent (murine-induced [iPSCs] murine embryonic [ESCs]) respond to nanocomposite fibrous mats of poly(L-lactic acid) (PLLA) loaded with 1 or 8 wt % calcium-deficient nanohydroxyapatite (d-HAp). Remarkably, the dispersion different amounts d-HAp PLLA produced a set materials (PLLA/d-HAp) similar architectures tunable mechanical properties. After 3 weeks culture in absence...
The tumor, node, metastasis (TNM) system has become the principal method for assessing extent of disease, determining prognosis in gastric cancer patients, and affecting therapy strategies. lymph node is most important prognostic factor. aim this study was to compare N-classifications 4th 5th-6th TNM editions evaluate retrospectively value 2002 edition. We evaluated 344 patients who underwent curative total or subtotal gastrectomy. Nodal involvement detected 221 (64%) patients. Median...
Background Large language models (LLMs) are advanced tools capable of understanding and generating human-like text. This study evaluated the accuracy several commercial LLMs in addressing clinical questions related to diagnosis management acute cholecystitis, as outlined Tokyo Guidelines 2018 (TG18). We assessed their congruence with expert panel discussions presented guidelines. Methods ChatGPT4.0, Gemini Advanced, GPTo1-preview on ten questions. Eight derived from TG18, two were formulated...
This study investigated how the design of surface topography may stimulate stem cell differentiation towards a neural lineage. To this end, hydrogenated amorphous carbon (a-C:H) groove topographies with width/spacing ridges ranging from 80/40μm, 40/30μm and 30/20μm depth 24 nm were used as single mechanotransducer stimulus to generate cells human bone marrow mesenchymal (hBM-MSCs) in vitro. As comparative experiments, soluble brain-derived neurotrophic factor (BDNF) was additional...
The interaction between stem cells and biomaterials with nanoscale topography represents a main route in the roadmap for tissue engineering–based strategies. In this study, we explored interface human bone marrow–derived mesenchymal (hBM-MSCs) hydrogenated amorphous carbon (a-C:H) film designed uniform, groove, or grid nanopatterns. either case, hBM-MSCs preserved growth rate multi-differentiation properties, suggesting that films were biocompatible suitable cell culture. responded to...
It is a general concern that the success of regenerative medicine-based applications based on ability to recapitulate molecular events allow stem cells repair damaged tissue/organ. To this end biomaterials are designed display properties that, in precise and physiological-like fashion, could drive cell fate both vitro vivo. The rationale highly sensitive forces they may convert mechanical stimuli into chemical response. In review, we describe novelties interactions with more focus...
Abstract The promising perspectives of PLLA‐based nanostructured biomaterials and their relevance in tissue engineering are reported. Nanocomposites based on PLLA MWCNTs developed with an MWCNT content ranging from 0 to 3 wt%. electrical properties show a percolation threshold within range 0.21–0.33 wt% MWCNTs, the conductivity increases by six orders magnitude. surface structure shows changes carbon nanotube concentration. functional role incorporation terms interactions adult stem cells...
Electrospinning of bioresorbable polymers is a promising and valuable scaffolding technique. To improve its potential applications, the addition specific fillers has been considered. This paper reports fabrication electrospun poly(L-lactic acid)/Ca-deficient-hydroxyapatite (PLLA/dHAp) mats, content nanosized d-HAp ranged between 1 8 wt%. All samples consisted micrometric submicrometric fibers, comprising 2D voids 13 µm for PLLA PLLA/d-HAp respectively. The surface fibers was characterized by...
The aim of this study was to investigate the presence synovial mast cells (MCs) in hip and knee tissue from osteoarthritis (OA) patients correlate them with clinical radiological data.Synovial obtained during arthroplasty 60 patients, 30 OA OA. Control without OA, 15 undergoing above-knee amputation receiving a replacement for fracture. Before surgery, radiographic findings were graded according Kellgren-Lawrence system data including pain (VAS) functional information (KOOS HOOS) collected....
Abstract The laparoscopic approach represents the standard of treatment for renal and adrenal diseases, its use is increasing even outside referral centres. Although most procedures are routinely performed, intraoperative complications do not occur, rate predictive factors these have been established. aim this study was to evaluate incidence type identify in patients undergoing surgery. This a cohort, multicentre, international retrospective study. Patients who underwent surgeries between...
Liver resection is considered the therapeutic gold standard for primary and metastatic liver neoplasms. The reduction of postoperative complications mortality has resulted in a more aggressive approach to hepatic malignancies. For most part, results surgery have been published by highly experienced institutions, but observations specialized units may not reflect current status surgery, underestimating complications. objective this study evaluate morbidity as result lesions, analyzing large...
The effectiveness of therapeutic treatment based on regenerative medicine for degenerative diseases (i.e., neurodegenerative or cardiac diseases) requires tools allowing the visualization and analysis three-dimensional (3D) distribution target drugs within tissue. Here, we present a new computational procedure able to overcome limitations visual emerging by examination molecular signal images serial tissue/organ sections using conventional techniques. Together with 3D anatomical...