Mahmoud Samir

ORCID: 0000-0001-9390-5797
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Research Areas
  • Animal Virus Infections Studies
  • Viral gastroenteritis research and epidemiology
  • Virus-based gene therapy research
  • Virology and Viral Diseases
  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • interferon and immune responses
  • Vector-Borne Animal Diseases
  • Influenza Virus Research Studies
  • Poxvirus research and outbreaks
  • Plant Virus Research Studies
  • Viral Infectious Diseases and Gene Expression in Insects
  • Bone Tissue Engineering Materials
  • Biomarkers in Disease Mechanisms
  • Dental Implant Techniques and Outcomes
  • Yersinia bacterium, plague, ectoparasites research
  • SARS-CoV-2 detection and testing
  • Sleep and Wakefulness Research
  • Nuclear Receptors and Signaling
  • Ancient Egypt and Archaeology
  • Cytomegalovirus and herpesvirus research
  • Obstructive Sleep Apnea Research
  • Microbial infections and disease research
  • Dental materials and restorations
  • Archaeology and Historical Studies

Al-Azhar University
2025

Agricultural Research Center
2021-2024

Animal Health Research Institute
2012-2024

Egypt Center for Research and Regenerative Medicine
2021

Cairo University
2020

Abstract Introduction Several observational studies reported an association between Rheumatoid Arthritis (RA) and the subsequent risk of developing Parkinson’s disease (PD). However, whether drugs commonly prescribed for RA contribute to this remains controversial. Content We sought summarize all published evidence regarding used PD as well explore potential neuroprotective therapeutic these patients. searched three electronic biomedical databases (namely, PubMed, Scopus, Web Science) find...

10.1515/nipt-2024-0023 article EN cc-by NeuroImmune Pharmacology and Therapeutics 2025-03-05

Fowl adenoviruses (FAdVs) are a large group of viruses different serotypes. They responsible for inclusion body hepatitis, adenoviral gizzard erosion, and hepatitis hydropericardium syndrome. The present study presents comprehensive overview FAdVs in Egypt, with focus on the epidemiological features virus serotypes across country. We conducted molecular investigation multiple FAdV species based genetic signature hypervariable regions 1-4 loop1 (L1) region hexon gene. Epidemiologically, Nile...

10.1016/j.heliyon.2021.e08366 article EN cc-by Heliyon 2021-11-15

Inclusion body hepatitis (IBH) is an economically significant viral disease that primarily affects broiler chickens. At least 12 different aviadenovirus serotypes are responsible for causing IBH. This study aimed to use polymerase chain reaction (PCR) and phylogenetic analysis characterize fowl adenovirus isolates were in circulation from 2019 2021 investigate the pathogenicity of isolated strains commercial Suspected liver samples molecularly identified using hexon gene targeting by PCR,...

10.1016/j.psj.2022.101918 article EN cc-by-nc-nd Poultry Science 2022-04-14

Avian adenoviruses are an extremely diversified group of pathogens that recently triggering a variety problems for poultry production. In particular, Inclusion Body Hepatitis-Hydropericardium Syndrome (IBH-HPS), which has been observed in broiler birds from 3 to 6 weeks age and is associated with anemia, hemorrhagic disorders, hydropericardium, high mortality. The disease reported worldwide, it was many Egyptian farms, causing severe economic losses. Therefore, the current study aimed...

10.54203/scil.2021.wvj46 article EN World s Veterinary Journal 2021-09-25

Current worldwide pandemic coronavirus disease 2019 (COVID-19) with high numbers of mortality rates and huge economic problems require an urgent demand for safe effective vaccine development. Inactivated SARS-CoV2 alum. Hydroxide can play important role in reducing the impacts COVID-19 pandemic. In this study, efficacy was evaluated through detection neutralizing antibodies that protect mice from challenge SARS-CoV 2 3 weeks after second dose. We conclude described here has safety desirable...

10.1093/abt/tbab012 article EN cc-by-nc Antibody Therapeutics 2021-06-25

<title>Abstract</title> Infectious bursal disease virus (IBDV) induces severe immunosuppression in chickens, leading to significant economic losses the global poultry industry. This study investigated 52 chicken flocks, including commercial broilers, layers, and baladi, from various Egyptian governorates for 2023. These flocks exhibited symptoms of depression, along with kidney bursa lesions, indicative IBDV infection. Pooled Bursal homogenates were tested using RT-PCR VP2-specific primers,...

10.21203/rs.3.rs-4875087/v1 preprint EN Research Square (Research Square) 2024-09-09

Abstract Infectious bursal disease virus (IBDV) induces severe immunosuppression in chickens, leading to significant economic losses the global poultry industry. This study investigated 52 chicken flocks, including commercial broilers, layers, and baladi, from various Egyptian governorates 2023. These flocks exhibited symptoms of depression, along with kidney bursa lesions, indicative IBDV infection. Pooled Bursal homogenates were tested using RT-PCR VP2-specific primers, revealing that 20...

10.1186/s12985-024-02559-9 article EN cc-by Virology Journal 2024-11-30

Abstract The current worldwide pandemic COVID-19 is causing severe human health problems, with high numbers of mortality rates and huge economic burdens that require an urgent demand for safe, effective vaccine development. Our study was the first trail to development evaluation safety immune response inactivated whole SARS-COV-2 virus adjuvanted aluminium hydroxide. We used characterized strain, acute respiratory syndrome coronavirus 2 isolates (SARS-CoV-2/human/EGY/Egy-SERVAC/2020)...

10.1101/2021.03.01.433130 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2021-03-02

1. Problematique et bilan des principaux resultats Situees a la marge/frontiere occidentale de l’Egypte, les deux bourgades Plinthine Taposiris ont chacune connu occupations longues multiformes, du Nouvel Empire l’epoque hellenistique, prenant le relai jusqu’aux lendemains conquete arabe. Depuis 2012, mission francaise Magna se concentre sur l’etude ...

10.4000/baefe.884 article FR cc-by-nc-nd Bulletin archéologique des Écoles françaises à l’étranger 2020-01-01

The current worldwide COVID-19 pandemic is causing severe human health problems, with high mortality rates and huge economic burdens requiring the urgent development of a safe effective vaccine. Here, preclinical evaluation an inactivated SARS-CoV-2 vaccine candidate (EgySerVac-20) reported. Oropharyngeal swabs nasopharyngeal aspirates obtained from Egyptian patients laboratory-confirmed infection were isolated using Vero cells then genetically characterized. Vaccine inactivation was...

10.33425/2768-4598.1001 article EN Archives of Clinical Trials 2021-03-30

Abstract Chicken astroviruses (CAstV) were associated with retarded growth, enteritis, kidney diseases, and white chick syndrome. In the current study, we aimed to evaluate effect of CAstV infection on performance, gross histopathological picture commercial chicken flocks suffering increased culling rate decreased performance. Samples collected for virus isolation, identification, sequencing day one, 15 days, 30 days age. Body weight, feed conversion rate, mortality rates determined. A...

10.1007/s11259-023-10109-x article EN cc-by Veterinary Research Communications 2023-03-28

Avian influenza virus (AIV) and Newcastle disease (NDV) are respiratory illness syndromes that have recently been detected in vaccinated flocks causing major financial losses the chicken farming industry. The objective was to evaluate efficacy of Valley Vac H5Plus NDVg7 vaccine protecting chickens against H5N8 NDV strains circulating comparison with commercially available bivalent H5+ND7 vaccine. In contrast vaccine, which made genetically distinct H5N8/2018 clade 2.3.4.4b genotype group...

10.1016/j.psj.2023.102952 article EN cc-by-nc-nd Poultry Science 2023-07-22

Aim:To accomplish a comparative study between two types of attachment Equator and Ball/Socket in mandibular implant supported overdenture by using finite element analysis assessment stress distribution on the bone, implant.overdenture, mucosa attachment.Methodology: Three-dimensional models simulated clinical situation where an edentulous mandible was restored different treatment options overdentures.The overdentures were implants placed at approximate canine region attachments.The load...

10.31080/asds.2020.05.1004 article EN Acta Scientific Dental Scienecs 2020-11-28

In the present study, antiviral activity of Curcumin (Curcuma longa) and bottle gourd (Lagenaria siceraria) extracts was evaluated against field vaccine strains Marek's disease virus (MDV).Plaque reduction assays were performed obtained results showed that both had a effect on number plaques in comparison with control vaccines.Curcumin exhibited prominent expressed as 80% 66% plaque percent (PR%) HVT Rispen's respectively at 1:8 dilution.While, has moderate action 1:4 dilution; it 40% 33%...

10.17582/journal.aavs/2021/9.10.1525.1531 article EN Advances in Animal and Veterinary Sciences 2021-01-01
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