A5100758224- RNA modifications and cancer
- Animal Virus Infections Studies
- Molecular Biology Techniques and Applications
- Virus-based gene therapy research
- Gastric Cancer Management and Outcomes
- Pleural and Pulmonary Diseases
- Viral gastroenteritis research and epidemiology
- Esophageal Cancer Research and Treatment
- Ferroptosis and cancer prognosis
- Congenital heart defects research
- Cancer-related gene regulation
- Marine Sponges and Natural Products
- Medical Imaging and Pathology Studies
- Glutathione Transferases and Polymorphisms
- Plant Molecular Biology Research
- Esophageal and GI Pathology
- Cardiac Ischemia and Reperfusion
- Wnt/β-catenin signaling in development and cancer
- Lung Cancer Treatments and Mutations
- Neuropeptides and Animal Physiology
- Plant nutrient uptake and metabolism
- Cancer, Hypoxia, and Metabolism
- Phytoestrogen effects and research
- Bioactive Natural Diterpenoids Research
- Plant biochemistry and biosynthesis
Shanghai East Hospital
2007-2025
Sichuan University
2025
University of Glasgow
2024
East China University of Science and Technology
2022
China Agricultural University
2022
Guizhou Normal University
2022
Tongji University
2021-2022
Zhengzhou University
2019
University of Alabama at Birmingham
2012-2015
Objective This study explores the differences in menopausal symptoms, illness conception, and health-seeking behaviors among Mosuo, Yi, Han women China, analyzes key factors behind these differences, conducts a longitudinal comparison. Methods collected data from Yongning Township, Ninglang County, Yunnan Province, through questionnaire survey. The instruments included Kupperman Menopause Index (KMI), Depression-Anxiety-Stress Scale (DASS), Self-Rating of Illness Conception Health Seeking...
Paclitaxel (Taxol™), an alkaloid of diterpenoid family, is one the most widely used anti-cancer drugs due to its effectiveness against a variety tumors. Rather than directly extraction and chemical synthesis paclitaxel or intermediates from yew plants, construction microbial cell factory for biosynthesis will be more efficient sustainable. The challenge lies on insufficient precursor, such as taxadien-5α-ol. In this study, we report recombinant Escherichia coli strain constructed with...
Congenital heart disease (CHD) is the most common birth defect and leading cause of infant morbidity mortality resulting from defects.Increasing evidence demonstrates that genetic variation in NKX2-5 gene, which encodes a homeobox-containing transcription factor crucial to cardiogenesis, an important molecular determinant for CHD.Nevertheless, components underlying CHD remain largely unknown.We screened potential defects patients with CHD.The entire coding region was initially sequenced...
Abstract Background Neoadjuvant chemoradiation followed by esophagectomy has been established as the first-line treatment for locally advanced esophageal cancer. Postoperative enteral nutrition widely used to improve perioperative outcomes. However, whether implement preoperative nutritional intervention during neoadjuvant therapy is yet be verified prospective studies. Methods POINT trial a multicenter, open-labeled, randomized controlled trial. A total of 244 patients with surgically...
Reverse transcription quantitative PCR (RT-qPCR) is considered the gold standard for quantifying relative gene expression. Normalization of RT-qPCR data commonly achieved by subtracting Ct values internal reference genes from target to obtain ΔCt. ΔCt are then used derive ΔΔCt when compared a control group or conduct further statistical analysis. We examined two rheumatoid arthritis low density array datasets and found that this normalization method introduces substantial bias due...
Objective To evaluate the myocardial protective effect of exogenous creatine phosphate added to a cardioplegic solution for elderly patients undergoing coronary artery bypass graft (CABG) in China. Methods Twenty-four (age>65 years) who underwent CABG were randomly divided into control group (n=12) and an experimental (n=12). The concentrations malonyldehyde superoxide dismutase blood measured before aortic clamping at 0, 30, 60, 120 min after release clamping. Creatine phosphokinase (CK),...
There is a rich literature describing the loss of dorsal root ganglion (DRG) neurons following peripheral axotomy, but vulnerability discrete subpopulations has not yet been characterised. Furthermore, extent or even presence neuron injury recently challenged. In this study, we have used range transgenic recombinase driver mouse lines to genetically label molecularly defined DRG and track their survival traumatic nerve injury. We find that spared leads marked cells containing volume...
Rhomboid domain containing 1 (RHBDD1), is a member of the rhomboid protease family, which has pivotal role in progression numerous severe malignancies. However, its colorectal carcinoma (CRC) remains to be elucidated. In present study, RHBDD1 was shown widely expressed CRC cell lines. Lentivirus‑mediated RNA interference employed knockdown expression RKO cells. Functional analyses indicated that depletion resulted significantly reduced proliferation and colony formation, induced G0/G1 phase...
Lung adenocarcinoma (LUAD), a major and fatal subtype of lung cancer, caused lots mortalities showed different outcomes in prognosis. This study was to assess key genes develop prognostic signature for the patient therapy with LUAD. RNA expression profile clinical data from 522 LUAD patients were accessed downloaded Cancer Genome Atlas (TCGA) database. Differentially expressed (DEGs) extracted analyzed between normal tissues samples. Then, 14-DEG developed identified survival prediction by...
Primulina tenuituba is a species in the Gesneriaceae family that widely distributed China. It karst-dwelling with an enormous tolerance for extreme drought and high temperatures. The also used traditional Chinese medicine. In this study, complete chloroplast genome of P. was assembled characterized first time. exhibited typical quadripartite cycle 153,236 bp length, including pair inverted repeats (IRs) 25,494 bp, which were separated by large single-copy (LSC) region 84,364 small single...
Although previous studies showed that women's menopause-related symptoms varied in different ethnic groups and countries, were affected by specific social cultural factors, few have been conducted to explore its influencing factors middle-aged women among China. This study aimed the characteristics of Mosuo, Yi, Han Yongning area Yunnan province, A cross-cultural design snowball sampling method was used recruit 208 aged 40-60 from Township, Ninglang County, The 11-item Menopause Rating Scale...
Abstract Objective The aim of this study was to assess the efficacy and safety intrapleural perfusion with hyperthermic chemotherapy (IPHC) in treating malignant pleural effusion (MPE) compared normothermic chemoperfusion cavity (NCPC), investigate better treatment control MPE. Methods Malignant patients were enrolled treated NCPC or IPHC under video‐assisted thoracoscopic surgery (VATS). chest drainage duration, clinical characteristics, recurrence time collected for statistical analysis....
Schizophrenia (SCZ), a severe neuropsychiatric disorder with high genetic susceptibility, has rates of misdiagnosis due to the unavoidably subjective factors and heterogeneous clinical presentations. Hypoxia been identified as an importantly risk factor that participates in development SCZ. Therefore, hypoxia-related biomarker for SCZ diagnosis is promising. we dedicated develop could contribute distinguishing healthy controls patients.
Abstract Objective To investigate the association between expression level of Von Hippel-Lindau(VHL) in pathological tissue and hematotoxicity platinum-based chemotherapy non-small cell lung cancer (NSCLC) patients. Methods The samples NSCLC patients were obtained for immunohistochemical staining to evaluate VHL. Furthermore, their clinical data collected prognosis was traced by phone. correlation gene evaluated chi-square test. influence VHL on risk tested logistic regression model....
Objective To evaluate the influence of fast-track surgery in perioperative period on clinical outcomes patients at nutritional risk respectable esophageal cancer perioperatively.Methods A total 170 carcinoma receiving radical operation our hospital from January 2008 to December 2013 were randomly divided into two groups by simple random method (n =85 each):one group was treated with new concept FTS-based screening (FTS group),and other control received conventional management (CPM group).The...
Objective In a prospective randomized controlled pilot study, effects of postoperative pulmonary complications on conservative treatment surgery (CTS) and fast track (FTS) regimen in non-small cell lung cancer (NSCLC) patients undergoing lobectomy were compared.Methods Eighty who underwent radical surgical for disease from January 2008 to May 2010 our hospital random assigned either (40 FTS group) or CTS group). Study endpoints ( pneumonia, atelectasis, prolonged air leak ＞ 7 days); Further...