Dzmitry Klimuk
A5052175344- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Diagnosis and treatment of tuberculosis
- Mycobacterium research and diagnosis
- Biosimilars and Bioanalytical Methods
- Health Systems, Economic Evaluations, Quality of Life
- Mesenchymal stem cell research
- Scientific and Engineering Research Topics
- Infectious Diseases and Tuberculosis
- Healthcare Facilities Design and Sustainability
- Applied Advanced Technologies
- Healthcare Systems and Public Health
- HIV/AIDS drug development and treatment
- Pharmaceutical studies and practices
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- HIV, TB, and STIs Epidemiology
- HIV/AIDS Impact and Responses
Republican Scientific and Practical Centre of Pulmonology and Tuberculosis
2014-2023
University College London
2021
National Institute for Health Research
2021
University of Copenhagen
2017
Rigshospitalet
2017
To evaluate the access to comprehensive diagnostics and novel antituberculosis medicines in European countries.
A significant drop in tuberculosis (TB) case-finding has been widely reported during the period of COVID-19 pandemic. To address a decrease TB notification, Belarus introduced laboratory testing patients with laboratory-confirmed coronavirus disease 2019 (COVID-19). We conducted secondary analysis health records among 844 diagnosis who were admitted to repurposed departments at hospitals and tested by Xpert MTB/RIF (Cepheid Inc., Sunnyvale, CA, USA) five regions between April October 2021....
Abstract Background Early diagnosis of tuberculosis (TB) is important to reduce transmission, morbidity and mortality in people living with HIV (PLWH). Methods PLWH a TB were enrolled from clinics Eastern Europe followed until 24 months. Delayed was defined as duration symptoms (cough, weight-loss or fever) for ≥ 1 month before diagnosis. Risk factors delayed assessed using multivariable logistic regression. The effect on Kaplan–Meier estimates Cox models. Findings 480/740 patients (64.9%;...
Background Indicators of extensive disease—acid fast bacilli (AFB) smear positivity and lung cavitation—have been inconsistently associated with clinical rifampin-resistant/multidrug-resistant tuberculosis (RR/MDR-TB) outcomes. We evaluated the association these indicators end-of-treatment Methods did an individual participant data meta-analysis people treated for RR/MDR-TB longer regimens documented AFB chest radiography findings. compared smear-negative without cavities to people: (1)...
Approximately 85% of tuberculosis (TB) related deaths occur in low- and middle-income countries where health resources are scarce. Effective priority setting is required to maximise the impact limited budgets. The Optima TB tool has been developed support analytical capacity inform evidence-based processes for benefits package design. This paper outlines framework how it was applied Belarus, an upper-middle income country Eastern Europe with a relatively high burden TB. population-based...
There is limited evidence describing the safety and effectiveness of bedaquiline delamanid containing regimens in children adolescents with Multidrug-Resistant Tuberculosis (MDR-TB) Extensively Drug-Resistant (XDR-TB) globally. In this nationwide descriptive cohort study from Belarus, we examined adverse drug events, time to culture conversion, treatment outcomes including post-treatment recurrence among (<18 years age) treated and/or 2015 2019. Of 40 participants included (55% females;...
Tuberculosis (TB), including drug-resistant TB, is a serious problem in Belarus.To determine the prevalence of TB among health care workers (HCWs) along with patient characteristics, treatment outcomes and drug resistance patterns between 2008 2012.A retrospective national record review.There were 116 HCWs TB. Case notification rates higher than general population (349 vs. 40/100 000 2012). Most nurses (n = 46, 40%) or nurse assistants 37, 32%), female 100, 86%) aged 25-44 years 84, 72%)....
Background. To cure drug-resistant (DR) tuberculosis (TB), the antituberculous treatment should be guided by Mycobacterium drug-susceptibility testing (DST). In this study, we compared conventional DST performed in Minsk, Belarus, a TB DR high-burden country, with extensive geno- and phenotypic analyses at WHO Supranational Reference Laboratory Copenhagen, Denmark, for TB/HIV coinfected patients. Subsequently, results were related to regimen outcome. Methods. Thirty patients from Minsk...
The objective : to evaluate the effectiveness of treatment with autologous mesenchymal stromal cells (MSCs) in patients drug resistant pulmonary tuberculosis (DR TB). Subjects and Methods . 120 aged 18 61 years old were enrolled study. They all treated at Republican Scientific Practical Center Pulmonology Phthisiology from 2009 2018. Against background anti-tuberculosis treatment, (60 people) Main Group (MG) underwent bone marrow sampling then intravenous administration MSCs. Results average...
Currently, a new grouping of contingents is being developed that are registered at dispensary in anti- tuberculosis organizations, where place will be reserved for patients with relapses tuberculosis, taking into account data from social and medical characteristics, complex rehabilitation measures. Objective the study: to study characteristics recurrent pulmonary possibility early diagnosis successful treatment tuberculosis. The paper presents 460 It shown bulk persons who not engaged labor...