A5039635039- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Hormonal Regulation and Hypertension
- Liver Diseases and Immunity
- Hepatitis C virus research
- Gastrointestinal disorders and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Electrolyte and hormonal disorders
- Hepatitis Viruses Studies and Epidemiology
- Drug-Induced Hepatotoxicity and Protection
- Adrenal Hormones and Disorders
- Abdominal vascular conditions and treatments
- Neonatal Health and Biochemistry
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Trace Elements in Health
- Biliary and Gastrointestinal Fistulas
- Thermal Regulation in Medicine
- Helicobacter pylori-related gastroenterology studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Whipple's Disease and Interleukins
- Alcoholism and Thiamine Deficiency
- Liver physiology and pathology
- Neurosurgical Procedures and Complications
Centre Hospitalier Universitaire de Besançon
2012-2024
Hôpital Privé Jean Mermo
2010-2016
GTx (United States)
2016
Université de franche-comté
2012-2013
Observatoire des Sciences de l’Univers Terre Homme Environnement Temps Astronomie
2009
Les Hôpitaux de Chartres
2003-2006
Hôpital Fontmaure
2000-2002
Hôpital Laennec
1998
Hôpital Cochin
1998
Hôpital Beaujon
1997
Idiopathic noncirrhotic portal hypertension is a heterogeneous group of diseases characterized by in the absence cirrhosis. The efficacy and safety transjugular intrahepatic portosystemic shunt (TIPS) this population are unknown. charts patients with idiopathic undergoing TIPS seven centers between 2000 2014 were retrospectively reviewed. Forty-one included. Indications for recurrent variceal bleeding (n = 25) refractory ascites 16). Patients categorized according to presence 27) or 14)...
Background —Push-type enteroscopy, a recent method for investigating the small intestine, is currently undergoing assessment. Its diagnostic yield varies in studies reported to date. Aim —To assess value of push-type enteroscopy according indication. Patients and methods —From January 1994 September 1995, 152 consecutive patients (mean age 34 years) underwent (jejunoscopy, n=93; retrograde ileoscopy, n=17; double way n=42). The indications were: unexplained iron deficiency anaemia or...
Background and Study Aims: Gastric outlet obstruction is a late event in the natural history of biliopancreatic tumours. Metallic self-expanding stents inserted under endoscopic fluoroscopic guidance can be used for palliation. The aim this study was to evaluate feasibility, efficacy, complications duodenal stenting patients with malignant gastric obstruction. Patients Methods: Between August 1998 November 2001, 63 (31 women, 32 men; mean age 73 ± 12) presenting clinical symptoms underwent...
Summary Background Obeticholic acid (OCA) and fibrates are second‐line therapies for patients with primary biliary cholangitis (PBC) an inadequate response to ursodeoxycholic (UDCA). Aim To know whether OCA fibrates, administered together in combination UDCA, have additive beneficial effects difficult‐to‐treat PBC. Methods PBC treated ≥3 months (bezafibrate or fenofibrate) due failure of either therapy were included a multicentre, uncontrolled retrospective cohort study. Changes biochemical...
Objective: Because over 90% of serum cortisol is bound to albumin and corticosteroid-binding globulin (CBG), changes in these proteins can affect measures total levels cirrhotics without altering serum-free salivary concentrations. Methods: We assessed basal (T0) post-synacthen (T60) cortisol, 125 consecutive (95 non-septic 30 septic patients with a Child>8). Results: Serum significantly decreased from the Child A–C group, as did CBG levels, non-significant rise Non-septic low (≤25 g/L) or...
I dentifying cirrhosis with a poor short-term prognosis remains crucial for improving the allocation of liver grafts. The purpose this study was to assess prognostic value model combining variation C-reactive protein (CRP) levels within 15 days, Model End-Stage Liver Disease (MELD) score, and presence comorbidities in patients decompensated Child-Pugh score > B7 test relevance compensated cirrhosis. We collected data cirrhotic without hepatocellular carcinoma, extrahepatic malignancy, human...
Background/aims The variations in C-reactive protein (CRP) levels have been reported to prognostic significance decompensated cirrhotic patients. We aimed provide an external validation of a model combining for end-stage liver disease (MELD) and ‘sustained high CRP levels’ as main variables optimize the context transplantation by focusing on 3-month mortality with no consideration severe chronic extrahepatic diseases. Patients methods Data from patients enrolled CANONIC study were collected....
Abstract Background & Aim Copeptin, secreted stoichiometrically with vasopressin, demonstrated its prognostic role in various diseases other than cirrhosis. Methods We investigated the association between severity of cirrhosis and plasma concentrations copeptin, value copeptin 95 non‐septic cirrhotic patients (34 Child‐Pugh A, 29 CP‐B, 32 CP‐C), 30 septic a >8 (‘group D’), 16 healthy volunteers. Patients were followed for at least 12 months to assess composite endpoint death/liver...
A total of 2%-10% patients with vascular liver disease (VLD) have paroxysmal nocturnal hemoglobinuria (PNH). Eculizumab reduces complement-mediated haemolytic activity in PNH. This study was aimed at assessing the impact eculizumab on VLD outcome. Retrospective cohort PNH patients, Valdig registry, who had diagnosed between 1997 and 2019 is considered. exposure interest. Studied outcomes were death, venous thrombosis, bleeding, arterial ischemic event, infection, liver-related complications....
Whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a risk factor for splanchnic vein thrombosis (SVT) unknown. This study aims to assess the impact of SARS-CoV-2 on presentation and prognosis recent SVT identify specific characteristics SARS-CoV-2-associated SVT.This retrospective collecting health-related data 27 patients presenting with in context 12 Vascular Liver Disease Group (VALDIG) centres comparison 494 before pandemic.Twenty-one had portal or without...
V delta 3 usage and combinatorial expression of gamma regions was studied on peripheral T cells with a novel 3-specific mAb (p11.10b), generated against soluble 9V TCR. 3+ represented the vast majority 1/V 2- within blood mucosal lymphocytes. No preferential region noted cells, but frequency 9+ significantly lower among than 1+ or 2+ PBL. Phenotypic analysis cultured sorted p11.10b revealed presence lymphocytes unusual phenotypes. First, carrying two distinct surface TCR delta-chains,...
We aimed to evaluate the accuracy of dosage calprotectin in ascitic fluid (AF) using Quantum Blue assay, for prompt diagnosis spontaneous bacterial peritonitis (SBP).We prospectively collected 236 AF samples from 119 cirrhotic patients hospitalized two French centers between May 2016 and 2017. Bloody chylous/cloudy AF, secondary were excluded. SBP was diagnosed if neutrophils >250/mm3 standard cytology. The Reader selectively measured antigen (MRP8/14) 12 min within measurable range 0.18...
Abstract Background & Aims Copeptin is a stable cleavage product of the arginine vasopressin ( AVP ) precursor and equimolarly secreted with . currently considered reliable prognostic marker in wide variety diseases other than cirrhosis. We aimed to investigate association between severity cirrhosis copeptin concentrations confirm whether significance Methods One hundred eighty‐four cirrhotic patients hospitalized two tertiary referral centres were studied. Serum was measured samples...
The reported hepatotoxicity of methotrexate underlines the need for a repeated non-invasive and reliable evaluation liver fibrosis. We estimated, using strategy, prevalence significant fibrosis in patients treated by predictors (fibrosis≥F2).Fibrosis was prospectively evaluated 9 tests consecutive with psoriasis, rheumatoid arthritis, or Crohn's disease. Significant assessed without biopsy defining "specific method" (result given majority tests) "sensitive (at least one test indicating...
We aimed to assess the performance of a new strip (Periscreen) for rapid diagnosis spontaneous bacterial peritonitis (SBP).Ascitic fluid (AF) cirrhotic patients hospitalized between March 2014 and August 2015 was independently tested by two readers using strip, which has four colorimetric graduations (negative, trace, small, large). SBP diagnosed on neutrophils in ascites>250/mm3. Ascites not related portal hypertension were excluded.Overall, 649 from 21 French centers included 1,402 AF (803...