A5103360014- Biofuel production and bioconversion
- Anaerobic Digestion and Biogas Production
- Genomics and Phylogenetic Studies
- Microbial metabolism and enzyme function
- Ruminant Nutrition and Digestive Physiology
- Gut microbiota and health
- Soil Carbon and Nitrogen Dynamics
- NF-κB Signaling Pathways
- Microbial Community Ecology and Physiology
- Enzyme Production and Characterization
- Bacteriophages and microbial interactions
- Inflammatory Bowel Disease
- Enzyme-mediated dye degradation
- Milk Quality and Mastitis in Dairy Cows
- Pharmacological Effects and Toxicity Studies
- Mycobacterium research and diagnosis
- Curcumin's Biomedical Applications
- Complement system in diseases
- Probiotics and Fermented Foods
- Plant Pathogens and Fungal Diseases
- Microbial infections and disease research
- Chromium effects and bioremediation
- Pharmacological Effects of Medicinal Plants
- Blood groups and transfusion
- Bioactive Natural Diterpenoids Research
AgResearch
2014-2024
Plant & Food Research
2014
Imperial College London
2004-2007
Rumen microbiome biology gets a boost with the release of 410 high-quality reference genomes from Hungate1000 project. Productivity ruminant livestock depends on rumen microbiota, which ferment indigestible plant polysaccharides into nutrients used for growth. Understanding functions carried out by microbiota is important reducing greenhouse gas production ruminants and developing biofuels lignocellulose. We present cultured bacteria archaea, together their genomes, representing every...
Methanosarcina species are the most metabolically versatile of methanogenic Archaea and can obtain energy for growth by producing methane via hydrogenotrophic, acetoclastic or methylotrophic pathways. barkeri CM1 was isolated from rumen a New Zealand Friesian cow grazing ryegrass/clover pasture, its genome has been sequenced to provide information on phylogenetic diversity methanogens with view developing technologies mitigation. The 4.5 Mb chromosome an average G + C content 39 %, encodes...
Inflammatory bowel disease (IBD) is a chronic relapsing disease. Genetic predisposition to the reduces an individual’s capacity respond appropriately environmental challenges in intestine leading inappropriate inflammation. IBD patients often modify their diet mitigate or reduce severity of Turmeric (Curcuma longa L., Zingiberaceae) has historically been used Chinese, Hindu, and Ayurvedic medicine over several centuries treat inflammatory disorders. To understand how turmeric may influence...
Methane is a potent greenhouse gas, 25 times more efficient at trapping heat than carbon dioxide. Ruminant methane emissions contribute almost 30% to anthropogenic sources of global atmospheric levels and reduction in would significantly slowing temperature rises. Here we demonstrate the use lytic enyzme, PeiR, from methanogen virus that infects Methanobrevibacter ruminantium M1 as an effective agent inhibiting range rumen strains pure culture. We determined substrate specificity soluble...
Abstract Acetogens are a specialized group of anaerobic bacteria able to produce acetate from CO 2 and H via the Wood–Ljungdahl pathway. In some gut environments acetogens can compete with methanogens for , as result rumen interest in development microbial approaches methane mitigation. The acetogen Eubacterium limosum SA11 was isolated New Zealand sheep its genome has been sequenced examine potential application mitigation strategies, particularly situations where hydrogenotrophic inhibited...
Abstract To investigate the role of mannose-binding lectin-A (MBL-A) in protection against infectious disease, MBL-A−/−-deficient mice were generated. Using a well-characterized mouse model human filarial nematode infection, survival and protective immune responses tested vivo. Blood-borne Brugia malayi microfilariae survived for significantly longer time periods MBL-A−/− than wild-type (WT) mice. However, no differences either splenic cytokine or induction leukocytes blood observed. A...
Agricultural methane produced by archaea in the forestomach of ruminants is a key contributor to rising levels greenhouse gases leading climate change. Functionalized biological polyhydroxybutyrate (PHB) nanoparticles offer new concept for reduction enteric emissions inhibiting rumen methanogens. Nanoparticles were functionalized vivo with an archaeal virus lytic enzyme, PeiR, active against range Methanobrevibacter species. The impact methanogens was demonstrated pure cultures, batch and...
ABSTRACT Methanosphaera spp. are methylotrophic methanogenic archaea and members of the order Methanobacteriales with few cultured representatives. sp. ISO3-F5 was isolated from sheep rumen contents in New Zealand. Here, we report its complete genome, consisting a large chromosome megaplasmid (GenBank accession numbers CP118753 CP118754 , respectively).
The Mycobacteria are a genus of Actinobacteria that include human pathogens such as Mycobacterium tuberculosis (TB). Active TB disease can spread by airborne transmission to healthcare workers and their community. HHMI SEA-PHAGES program has contributed discovering bacteriophages able infect M. smegmatis MC 2 155, close relative . This collection diverse Mycobacteriophages is an excellent resource for trialling bacteriophage-sourced enzymes in novel applications. Herein we measured the...
Pectin is a complex polysaccharide that forms substantial proportion of the plant’s middle lamella forage ingested by grazing ruminants. Methanol in rumen derived mainly from methoxy groups released pectin action methylesterase (PME) and subsequently used methylotrophic methanogens reduce methanol to produce methane (CH4). Members genus Butyrivibrio are key pectin-degrading bacteria contribute formation have important roles fibre breakdown, protein digestion, biohydrogenation fatty acids....
The high mortality rate associated with Listeria monocytogenes and its ability to adapt the harsh conditions employed in food processing has ensured that this pathogen remains a serious problem ready-to-eat sector. Bacteriophage-derived enzymes can be applied as biocontrol agents target specific foodborne pathogens. We investigated of listeriophage endolysin derivatives thereof, fused polyhydroxyalkanoate bionanoparticles (PHA_BNPs), lyse inhibit growth L. monocytogenes. Turbidity reduction...
Agriculture is fundamental for food production, and microbiomes support agriculture through multiple essential ecosystem services. Despite the importance of individual (i.e., niche specific) agricultural microbiomes, microbiome interactions across niches are not well-understood. To observe linkages between nearby approaches (16S, 18S, ITS) were used to inspect a broad coverage microbiomes. Here we examined responses 3 different nitrogen treatments (0, 150, 300 kg/ha/yr) in soil tracked...
ABSTRACT Cladosporium and Epicoccum are cosmopolitan fungi of the class Dothideomycetes with few cultured genomic representatives. Here, we report draft reference genome sequences sp. F181 (GenBank accession number JAJSLS01 ), F165 ( JAJSLR01 F190 JAJSLT01 ) isolated from recycling waste management facilities in New Zealand.
Abstract Background Agriculture is fundamental for food production, and microbiomes support agricultural through multiple essential ecosystem services. Despite the importance of individual (i.e. niche specific) microbiomes, microbiome interactions across niches are not well-understood. To observe linkages between nearby approaches (16S, 18S, ITS) were used to inspect a broad coverage microbiomes. Here we examined responses 3 different nitrogen treatments (0 kg/ha/yr, 150kg/ha/yr 300kg/ha/yr)...