A5043158349- Head and Neck Cancer Studies
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Head and Neck Surgical Oncology
- Sinusitis and nasal conditions
- Voice and Speech Disorders
- Pediatric health and respiratory diseases
- Tracheal and airway disorders
- Brain Metastases and Treatment
- Medical Imaging Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Dysphagia Assessment and Management
- Advanced Radiotherapy Techniques
- Ear and Head Tumors
- Nasal Surgery and Airway Studies
- Radiomics and Machine Learning in Medical Imaging
- Dermatology and Skin Diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Respiratory and Cough-Related Research
- Oral health in cancer treatment
- Thyroid Cancer Diagnosis and Treatment
- Head and Neck Anomalies
Ghent University Hospital
2015-2024
Cancer Research Institute Ghent
2021-2024
Ghent University
2015-2023
Universitair Ziekenhuis Brussel
2021
University Medical Center Utrecht
2016
Background Most trials in head and neck cancer emphasize locoregional control, as this is the main pattern of therapy failure. However, up to 15% patients develop distant metastases. The purpose study was present investigated factors associated with metastasis a single-center patient cohort. Methods A retrospective analysis cohort over an 18-year period has been performed. We report on prevalence incidence metastasis, timing relation failure, Kaplan–Meier for actuarial control rates,...
<b><i>Background:</i></b> Allergic rhinitis (AR) is the most common allergic disorder and its prevalence has significantly increased worldwide, nowadays affecting up to 40% of population in young adults. The objective present survey was evaluate sensitization clinically diagnosed AR a sample Belgian population, estimate effect age gender. <b><i>Methods:</i></b> We performed cross-sectional population-based study at an annual public fair Ghent....
Abstract Background Acute and late toxicity after intensity‐modulated radiotherapy (IMRT) for head neck cancer (HNC) impacts on patient quality of life; yet, very data remain scarce. This study assessed dysphagia, xerostomia, fibrosis 3‐8 years IMRT. Methods A retrospective analysis using generalized estimated equations was performed 60 patients with HNC treated fractionated IMRT between 2000 2015 who had a follow‐up ≥8 years. Toxicity scored LENT‐SOMA scales. Results trend towards nonlinear...
Bacterial colonisation of the airways is associated with increased risk childhood asthma. Immunoglobulin (Ig)E against bacterial antigens has been reported in some asthmatics, suggesting a role for bacterial-specific type-2 immunity disease pathogenesis. We aimed to investigate relationships between IgE amongst teenagers and asthma susceptibility. measured titres Haemophilus influenzae, Streptococcus pneumoniae Staphylococcus aureus 1,380 teenagers, related these symptomatology...
Abstract Background The purpose of this study was to report the long‐term outcome 18 F‐fluorodeoxyglucose‐positron emission tomography ( F‐FDG‐PET)‐guided dose painting for head and neck cancer in comparison conventional intensity‐modulated radiotherapy (IMRT) a matched case‐control study. Methods Seventy‐two patients with nonmetastatic treated were compared 72 control on tumor site T classification. Either F‐FDG‐PET‐guided by contour (DPBC) or voxel intensity‐based number (DPBN) performed;...
Staphylococcus aureus Enterotoxin B (SEB) has immunomodulatory effects in allergic airway disease. The potential contribution of SEB to the sensitization process allergens remains obscure.In order study staphylococcal-derived toxins on ovalbumin (OVA) and induction inflammation, we have combined nasal application OVA with different toxins.Nasal applications saline, SEA, SEB, toxic shock syndrome toxin (TSST)-1, protein A or lipopolysaccharide (LPS) were performed alternate days from day 0...
Staphylococcus aureus enterotoxin B (SEB) has recently been postulated to be involved in the pathology of granulocyte-dominated disease. Studying immunologic interaction between SEB and airway epithelial cells immortalized cell lines or long-term cultures obvious disadvantages.We used a novel technique freshly isolated purified human nasal (HNEC) from healthy, nonallergic individuals, which were incubated for 24 h without/with at different concentrations. Chemokine production was evaluated...
ABSTRACT Poor postoperative healing after sinus surgery is associated with high concentrations of matrix metalloproteinase‐9 (MMP‐9). The frontal recess especially vulnerable to restenosis, and stents have been used overcome this problem. However, the long‐term success rate still controversial may be poor. In perspective, we developed doxycycline (DC)‐releasing stents, delivering MMP‐9 synthesis‐suppressing agent locally area. We evaluated levels, bacterial colonization, quality, symptom...
Cigarette smoke (CS) is known to initiate a cascade of mediator release and accumulation immune inflammatory cells in the lower airways. We investigated compared effects CS on upper airways, mouse model subacute chronic exposure. C57BL/6 mice were whole-body exposed mainstream or air, for 2, 4 24 weeks. Bronchoalveolar lavage fluid (BAL) was obtained tissue cryosections from nasal turbinates stained neutrophils T cells. Furthermore, we evaluated GCP-2, KC, MCP-1, MIP-3α, RORc, IL-17, FoxP3,...
Background: To identify predictive factors for the development of late grade 4 mucosal ulcers in adaptive dose-escalated treatments head-and-neck cancer.Material and methods: Patient data four three-phase dose-painting by numbers (DPBN) clinical trials were analyzed this study. Correlations between related with treatment, disease characteristics patient investigated. Dosimetrical thresholds searched among highest doses received 1.75 cm3 (D1.75cc) primary gross tumor volume (GTVT)...
Abstract Background Cigarette smoke (CS) is a major risk factor for the development of COPD. CS exposure associated with an increased bacterial colonization and respiratory tract infection, because suppressed antibacterial activities immune system delayed clearance microbial agents from lungs. Colonization Staphylococcus aureus results in release virulent enterotoxins, superantigen activity which causes T cell activation. Objective To study effect enterotoxin B (SEB) on CS-induced...
Postoperative scarring is a common cause of patient dissatisfaction. Several strategies have been developed to improve its clinical aspects.To assess efficacy and safety the 10,600 nm ablative fractional carbon dioxide (CO2) laser in treatment recent surgical scars head neck region.A prospective, randomized, single-blind intrapatient controlled study was conducted on 9 postoperative region. On half scar, 3 sessions were performed. Physician/Patient Global Assessment (PhGA/PGA) Patient...
The surgical treatment of head and neck malignancies relies on the complete removal tumoral tissue, while inadequate margins necessitate use adjuvant therapy. However, most positive are identified postoperatively as deep margins, intraoperative identification could help achieve adequate decrease therapies. To improve deep-margin identification, we investigated whether high-resolution preclinical PET CT increase certainty about in three dimensions. Patients with a malignancy planned for...
Patients diagnosed with radioiodine refractory (RAI-R) thyroid carcinoma (TC) have a significantly worse prognosis than patients radiosensitive TC. These malignancies are often dedifferentiated, hindering the effectiveness of iodine-based imaging. Additionally, role metabolic imaging using [
Background/Purpose: We analyzed complications and functional outcomes aimed at identifying prognostic factors for in patients who underwent salvage total laryngectomy (STL) residual, recurrent, second primary squamous cell carcinoma (SCC) of the larynx hypopharynx after initial (chemo)radiation. Methods: Retrospective cohort study STL four major Belgian reference hospitals between 2002 2018. Prognostic were identified with uni- multivariable analysis. Results: A 405 included final was...