A5038470846- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Anesthesia and Pain Management
- Sinusitis and nasal conditions
- COVID-19 Clinical Research Studies
- Olfactory and Sensory Function Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Nasal Surgery and Airway Studies
- Respiratory and Cough-Related Research
- Neonatal Respiratory Health Research
- Nausea and vomiting management
- Sepsis Diagnosis and Treatment
- Dermatology and Skin Diseases
- Ocular Surface and Contact Lens
- Mechanical Circulatory Support Devices
- Respiratory Support and Mechanisms
- Orthopedic Surgery and Rehabilitation
- Long-Term Effects of COVID-19
- Spine and Intervertebral Disc Pathology
- Head and Neck Surgical Oncology
- Intensive Care Unit Cognitive Disorders
- Pediatric Pain Management Techniques
- COVID-19 and healthcare impacts
- Reproductive System and Pregnancy
- Enhanced Recovery After Surgery
Jessa Hospital
2020-2025
Hasselt University
2020-2025
KU Leuven
2009-2022
Universitair Ziekenhuis Leuven
2017-2020
Hospital Clínic de Barcelona
2018
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2018
Biomed Research Institute
2018
Universitat de Barcelona
2018
Laboratory of Molecular Genetics
2012
Institut Pasteur
1992
Abstract Background Patients infected with severe acute respiratory syndrome coronavirus (SARS-CoV-2) can develop illness necessitating intensive care admission. Critically ill patients are susceptible for the development of secondary bacterial infections. Due to a combination virus- and drug-induced immunosuppression, critically corona virus disease 2019 (COVID-19) may even have higher risk developing infection. These infections aggravate severity increase death. Further research on in...
Airway hyperreactivity (AHR) is a key feature of bronchial asthma, and inhalation irritants may facilitate development nonallergic AHR. Swimmers exposed to hypochlorite (ClO(-))-containing water show higher risk developing We developed mouse model in which instillation ClO(-) before ovalbumin (OVA) induces AHR without inflammatory cells.To investigate the mechanisms ClO(-)-OVA-induced AHR.The involvement transient receptor potential ankyrin (TRPA)1 channel was checked vivo by use TRPA1(-/-)...
Abstract Background Chronic rhinosinusitis (CRS) is a chronic inflammatory disease associated with substantial personal and socioeconomic burden. Monitoring of patient‐reported outcomes by mobile technology offers the possibility to better understand real‐life burden CRS. Methods This study reports on cross‐sectional evaluation data 626 users mySinusitisCoach (mSC), application for CRS patients. Patient characteristics mSC were analysed as well level control based VAS global symptom score...
Abstract Background Nasal hyperreactivity ( NHR ) is an important clinical feature of allergic rhinitis AR ). The efficacy MP 29‐02 (azelastine hydrochloride AZE and fluticasone propionate [ FP ]) nasal spray on local inflammatory mediators in unknown. We tested if decreases this effect due to restoration epithelial barrier function. Methods A 4‐week double‐blinded placebo‐controlled trial with treatment was conducted 28 patients house dust mite HDM . presence evaluated by measuring...
Auto-intoxication represents a considerable number of Intensive care unit (ICU) admissions. Literature focusing on characteristics and outcomes ICU-admitted auto-intoxicated patients is limited. We aimed to identify the quantity intensive admissions attributable auto-intoxication in Belgian tertiary center, examine these patients, assess impact covid-19 pandemic variables. In this retrospective cohort study, all admitted ICU JESSA hospital, Hasselt, Belgium with diagnosis between January 1st...
Staphylococcus aureus Enterotoxin B (SEB) has immunomodulatory effects in allergic airway disease. The potential contribution of SEB to the sensitization process allergens remains obscure.In order study staphylococcal-derived toxins on ovalbumin (OVA) and induction inflammation, we have combined nasal application OVA with different toxins.Nasal applications saline, SEA, SEB, toxic shock syndrome toxin (TSST)-1, protein A or lipopolysaccharide (LPS) were performed alternate days from day 0...
The first European Rhinology Research Forum organized by the for and Education in Allergy Airway Diseases (EUFOREA) was held Royal Academy of Medicine Brussels on 17th 18th November 2016, collaboration with Rhinologic Society (ERS) Global Asthma Network (GA2LEN). One hundred thirty participants (medical doctors from different specialties, researchers, as well patients industry representatives) 27 countries took part multiple perspective discussions including brainstorming sessions care...
Background. Severity scoring systems are inherent to ICU practice for multiple purposes. Acute Physiology and Chronic Health Evaluation (APACHE) designed mortality prediction. This study aims validate APACHE IV in COVID-19 patients admitted the ICU. Methods. All between March 13, 2020, October 17, were retrospectively analyzed. II scores as well SOFA calculated within 24 hours after admission. Discrimination of all three was assessed by receiver operating characteristic curves. Youden index...
Although the concept of "global airway allergy" has become widely accepted during recent years, nasobronchial interaction and its mechanisms remain incompletely understood. The experimental study effect nasal allergen deposition on lower pathology is hampered by difficulty avoiding penetration allergens. In ovalbumin-sensitized mice with allergy, provocations were performed after complete anatomical separation upper airways means a tracheotomy. A canula was inserted in trachea, trachea...
Staphylococcus aureus enterotoxin B (SEB) has recently been postulated to be involved in the pathology of granulocyte-dominated disease. Studying immunologic interaction between SEB and airway epithelial cells immortalized cell lines or long-term cultures obvious disadvantages.We used a novel technique freshly isolated purified human nasal (HNEC) from healthy, nonallergic individuals, which were incubated for 24 h without/with at different concentrations. Chemokine production was evaluated...
Introduction Serratus anterior plane block has been proposed to reduce opioid requirements after minimally invasive cardiac surgery, but high-quality evidence is lacking. Methods This prospective, double-blinded, randomized controlled trial recruited patients undergoing totally endoscopic aortic valve replacement. Patients in the intervention arm received a single-injection serratus on arrival intensive care unit added standard of care. control group routine care, including...
The immune response in patients with Coronavirus Disease 2019 (COVID-19) is highly variable and linked to disease severity mortality. However, antibody cytokine responses the early stage their association course outcome are still not completely understood. In this large, multi-centre cohort study, blood samples of 434 Belgian COVID-19 hospitalized different severities (ranging from asymptomatic/mild critically ill) first wave pandemic were obtained. Baseline characterized associations...
Placental growth factor (PlGF) and its receptor vascular endothelial 1 (VEGFR1) play an important role in pathological conditions related to angiogenesis, leakage, inflammation. This study investigated their contributions inflammation the formation of edema allergic asthma. The expression PlGF VEGFR1 was measured induced sputum patients with asthma (n = 11) healthy subjects 11), bronchial biopsies house dust mite (HDM)-allergic stimulated HDM allergens. effects endonasal administration human...
Forum organized by the European for Research and Education in Allergy Airway Diseases (EUFOREA) was held Royal Academy of Medicine Brussels on 17th 18th November 2016, collaboration with Rhinologic Society (ERS) Global Asthma Network (GA2LEN).One hundred thirty participants (medical doctors from different specialties, researchers, as well patients industry representatives) 27 countries took part multiple perspective discussions including brainstorming sessions care pathways research needs...
The Sequential Organ Failure Assessment (SOFA) score has been developed to the severity of organ dysfunction in critically ill sepsis patients and proven have a high predictive value for intensive care unit (ICU) mortality severely patients. Our goal was evaluate prognostic SOFA as well trends ICU COVID-19 patients.All consecutive with confirmed pneumonia admitted between March 13th, 2020, October 17th, 2020 were included this retrospective cohort study. worst evaluated daily. Multiple...
To cite this article: Callebaut I, Spielberg L, Hox V, Bobic S, Jorissen M, Stalmans Scadding G, Ceuppens JL, Hellings PW. Conjunctival effects of a selective nasal pollen provocation. Allergy 2010; 65 : 1173–1181. Abstract Background: Several clinical and experimental observations suggest that allergen deposition in the nose may partially be responsible for induction conjunctival symptoms allergic rhinitis. The aims study were to evaluate by provocation assess feasibility different tools...
BACKGROUND: Human nasal epithelial cells (hNECs) are the first line of immune defense and able to produce mediators that recruit, activate prolong survival cells, among which IL-8 takes an important place. Studies on effects dexamethasone hNECs have been hampered by methodological shortcomings. The purpose study is investigate contribution freshly isolated production in chronic rhinosinusitis with polyps (CRSwithNP). Secondly, treatment hNEC apoptosis investigated. METHODOLOGY: were from...
Background Edema represents a key feature of nasal polyp (NP) disease. Members the vascular endothelial growth factor (VEGF) family may be involved, but precise role VEGF-A, VEGF-B, placental (PlGF), and their receptors VEGFR1 VEGFR2 in NP edema formation remains elusive. Objective Exploring expression VEGF members correlation with clinical, radiological, markers NP. Methods The PlGF, VEGFR1, was measured (n = 23) control tissue 22) at mRNA protein level. evaluated by measuring albumin...