A5044752068- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Noise Effects and Management
- Health, Environment, Cognitive Aging
- Thermoregulation and physiological responses
- Skin Protection and Aging
- Air Quality Monitoring and Forecasting
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Health and Medical Studies
- Energy and Environment Impacts
- Dermatologic Treatments and Research
- Global Health Care Issues
- Hearing Loss and Rehabilitation
- Genetics, Bioinformatics, and Biomedical Research
- Breast Cancer Treatment Studies
- Genetic Mapping and Diversity in Plants and Animals
- Psychological and Temporal Perspectives Research
- Vehicle Noise and Vibration Control
- Dental Health and Care Utilization
- Genetic Associations and Epidemiology
- melanin and skin pigmentation
- Cancer Risks and Factors
- Blood Pressure and Hypertension Studies
- Urban Agriculture and Sustainability
- HIV/AIDS oral health manifestations
Leibniz Institute of Environmental Medicine
2019-2024
Oxfam
2020
John Wiley & Sons (United States)
2020
John Wiley & Sons (United Kingdom)
2020
Hudson Institute
2020
TU Dortmund University
2020
The detrimental effects of traffic noise on cognition in children are well documented. Not much is known about the health adults. We investigated association residential exposure to road and annoyance due with cognitive function a cohort 288 elderly women from longitudinal Study influence Air pollution Lung function, Inflammation Aging (SALIA) Germany. Residential levels-weighted 24-h mean (LDEN) nighttime (LNIGHT)-were modeled for most exposed facade dwellings dichotomized at ≥50 dB(A)....
Neurotoxicity is mediated by a variety of modes-of-actions leading to disturbance neuronal function. In order screen larger numbers compounds for their neurotoxic potential, in vitro functional networks (NN) might be helpful tools. We established and characterized human NN (hNN) from hiPSC-derived neural progenitor cells comparing hNN formation with two different differentiation media: presence (CINDA) absence (neural medium (NDM)) maturation-supporting factors. As control we included...
Background Air pollution is a risk factor for chronic obstructive pulmonary disease (COPD). Fraction of exhaled nitric oxide (FeNO) could be useful biomarker health effects air pollutants. However, there were limited data from older populations with higher prevalence COPD and other inflammatory conditions. Methods We obtained the German Study on influence Lung function, Inflammation Ageing. Spirometry FeNO measured by standard techniques. pollutant exposures estimated following European...
Although desert dust promotes morbidity and mortality, it is exempt from regulations. Its health effects have been related to its inflammatory properties, which can vary between source regions. It remains unclear constituents cause this variability. Moreover, whether long-range transported potentiates the hazardousness of local particulate matter (PM) still unresolved. We aimed assess influence on potency PM2.5 PM10 collected in Cape Verde examine associated constituents. During a reference...
Zusammenfassung Hintergrund Personen mit Migrationshintergrund (PmM) unterscheiden sich als Bevölkerungsgruppe hinsichtlich Morbidität, Mortalität und Inanspruchnahme des Gesundheitssystems meist von der autochthonen Bevölkerung, sie nehmen jedoch seltener an Gesundheitsstudien teil. Die Gruppe PmM ist sehr heterogen, was in Studien bisher kaum berücksichtigt wird. Ziel Arbeit Es werden soziodemografische Charakteristika NAKO Gesundheitsstudie (Alter, Geschlecht, Zeit seit Migration,...
Genetic risk scores (GRS) summarize genetic features such as single nucleotide polymorphisms (SNPs) in a statistic with respect to given trait. So far, GRS are typically built using generalized linear models or regularized extensions. However, these methods usually not able incorporate gene-gene interactions non-linear SNP-response relationships. Tree-based statistical learning random forests and logic regression may be an alternative regularized-regression-based investigated this article....
Air pollutants can activate low-grade subclinical inflammation which further impairs respiratory health. We aimed to investigate the role of polygenic susceptibility chronic air pollution-induced airway inflammation.We used data from 296 women (69-79 years) enrolled in population-based SALIA cohort (Study on influence pollution Lung function, Inflammation and Aging). Biomarkers were measured induced-sputum samples at follow-up investigation 2007-2010. Chronic exposures residential addresses...
Abstract Background Telangiectasia or red veins are one of the prominent features facial skin ageing. To date, there few studies investigating determinants telangiectasia. Objectives We investigated lifestyle and physiological factors associated with telangiectasia in a large prospective Dutch cohort study. Methods was quantified digitally from standardized photographs 2842 North European participants (56.8% female, median age 66.9) Rotterdam Study, collected 2010–2013. Effect estimates...
Air pollution exposure is associated with reduced lung function and increased cardio-pulmonary mortality (CPM).We analyzed the potential mediating effect of on association between air CPM.We used data from German SALIA cohort including 2527 elderly women (aged 51-56 years at baseline 1985-1994) 22-year follow-up to CPM. Exposures PM10, PM2.5, PM2.5 absorbance, NO2 NOx were assessed by land-use regression modelling back-extrapolated estimate exposures baseline. Lung (FVC, FEV1) was measured...
Caries and periodontitis are highly prevalent worldwide. Because detailed data on these oral diseases were collected within the framework of German National Cohort (GNC), associations between systemic conditions can be investigated.The study protocol for examination was designed to ensure a comprehensive collection dental findings by trained non-dental staff limited time. At mid-term GNC baseline examination, first quality evaluation performed check plausibility results propose measures...
Noise annoyance is associated with adverse health-related conditions and reduced wellbeing. Thereby, subjective noise depends on the objective exposure modified by personal regional factors.How many participants of German National Cohort Study (GNC; NAKO Gesundheitsstudie) were annoyed transportation during nighttime what factors annoyance?This cross-sectional analysis included 86,080 from 18 study centers, examined 2014 to 2017. We used multinomial logistic regression investigate...
Abstract Understanding intramammary estrogen homeostasis constitutes the basis of understanding role lifestyle factors in breast cancer etiology. Thus, aim present study was to identify variables influencing levels estrogens normal glandular and adipose tissues (GLT ADT, i.e., 17β-estradiol, estrone, estrone-3-sulfate, 2-methoxy-estrone) by multiple linear regression models. Explanatory (exVARs) considered were (a) metabolic precursors as well transcripts encoding proteins involved...
The severity of facial telangiectasia or red veins is associated with many lifestyle factors. However, the genetic predisposition remains unclear.We performed a genome-wide association study (GWAS) on in Rotterdam Study (RS) and tested for replication two independent cohorts. Additionally, candidate gene approach known pigmentation genes was performed.Facial were extracted from standardized photographs (collected 2010-2013) 2842 northwestern European participants (median age 66.9, 56.8%...
Genetic and exposomal factors contribute to the development of human aging. For example, genetic polymorphisms exposure environmental (air pollution, tobacco smoke, etc.) influence lung skin aging traits. prevention purposes it is highly desirable know extent which each category exposome their development. Estimating such extents, however, methodologically challenging, mainly because predictors are often correlated. Tackling this challenge, article proposes use weighted risk scores assess...
There is no doubt that global warming, with its extreme heat events, having an increasing impact on human health. Heat not independent of ambient temperature but acts synergistically relative humidity (RH) to increase the risk several diseases, such as cardiovascular and pulmonary diseases. Although skin organ in direct contact environment, it currently unknown whether health similarly affected.