A5101697985- Glioma Diagnosis and Treatment
- Microbial infections and disease research
- Bacteriophages and microbial interactions
- RNA modifications and cancer
- RNA Research and Splicing
- Growth Hormone and Insulin-like Growth Factors
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- MicroRNA in disease regulation
- RNA regulation and disease
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Histone Deacetylase Inhibitors Research
- Toxoplasma gondii Research Studies
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Mycobacterium research and diagnosis
- Gene expression and cancer classification
- Cancer Cells and Metastasis
- Ubiquitin and proteasome pathways
- Pituitary Gland Disorders and Treatments
- Neuroblastoma Research and Treatments
Huazhong University of Science and Technology
2024
University of Science and Technology of China
2024
Capital Medical University
2009-2019
Chinese Institute for Brain Research
2016-2019
Beijing Institute of Neurosurgery
2016-2018
Peking University Cancer Hospital
2012-2014
Peking University
2012-2014
Chinese Academy of Sciences
2009-2013
Jiangsu Provincial Hospital of Traditional Chinese Medicine
2012
Center for Theoretical Biological Physics
2012
Genome-wide microRNA (miRNA) profiling of 82 glioblastomas demonstrated that miR-181d was inversely associated with patient overall survival after correcting for age, Karnofsky performance status, extent resection, and temozolomide (TMZ) treatment. This association validated using the Cancer Genome Atlas (TCGA) dataset (n= 424) an independent cohort 35). In these cohorts, evident in patients who underwent TMZ treatment but not observed without therapy. Bioinformatic analysis potential genes...
Insulin-like growth factor binding protein 2 (IGFBP-2) is a malignancy-associated measurable in tumors and blood. Increased IGFBP-2 associated with shortened survival of advanced glioma patients. Thus, we examined plasma levels patients healthy controls to evaluate its value as biomarker for glioma. Plasma 196 newly diagnosed 55 were analyzed using an ELISA kit. Blood was collected before surgery, after two-cycle adjuvant chemotherapy, at recurrence. correlated disease-free (DFS) Cox...
Abstract BACKGROUND: More reliable clinical outcome prediction is required to better guide more personalized treatment for patients with primary glioblastoma multiforme (GBM). The objective of this study was identify a microRNA expression signature improve GBM. METHODS: A cohort Chinese GBM (n = 82) analyzed using whole‐genome profiling divided into training set and testing set. Cox regression risk‐score analyses were used develop 5‐microRNA 41 samples. validated in other test samples, an...
Our previous studies have shown that insulin-like growth factor binding protein 2 (IGFBP-2) is frequently overexpressed in the highly invasive glioblastoma multiforme (GBM). By using a yeast two-hybrid system, we identified gene, invasion inhibitory 45 ( IIp45 ), whose product bound to IGFBP-2 through thyroglobulin-RGD region of C terminus IGFBP-2. The gene located on chromosome 1p36 and has nine exons. three SEG (segment low compositional complexity) domains an integrin-binding RGD motif....
IIp45 (aka MIIP) is a newly discovered gene whose protein product inhibits cell migration. HDAC6 class IIb deacetylase that specifically deacetylates alpha-tubulin, modulates microtubule dynamics, and promotes A yeast two-hybrid assay using as bait identified binding partner of IIp45. This physical interaction the two functionally antagonistic proteins was confirmed by glutathione S-transferase pulldown co-immunoprecipitation in human cells. Serial deletion constructs were used to...
Chronic infection of Mycoplasma hyorhinis (M. hyorhinis) has been postulated to be associated with several types cancer, but its effect on patients' survival and host factors mediating remain unclear. Herein, we demonstrated that M. p37 protein expression in gastric cancer tissues predicts poor associates metastasis. infects mammalian cells promotes cell invasiveness via membrane p37. Synthesized peptide corresponding the N-terminus prevents infection. Host Annexin A2 (ANXA2) interacts In...
Immunotherapy shows a promise for treating glioblastoma (GBM), the most malignant and immunosuppressive glioma. The mesenchymal phenotype of cancer cells was frequently reported to be associated with their induction immunosuppression within microenvironment. Overexpressed insulin-like growth factor binding protein 2 (IGFBP2) promotes GBM cell migration invasion, contributes glioma progression recurrence poor survival in GBM. However, whether IGFBP2 can induce not yet. Thus, study applied...
Tumor multidrug resistance (MDR) can result from overexpression of drug transporters and deregulation cellular signaling transduction. New agents strategies are required for overcoming MDR. Here, we report that tanshinone-1, a bioactive ingredient in traditional Chinese medicine, directly killed MDR tumor cells their corresponding parental cells, which was potentiated by inhibition secondary activation networks. Tanshinone-1 slightly more potent at inducing cytotoxicity apoptosis than cells....
High grade gliomas contribute to most brain tumor mortality. A few studies reported that the immune system affected glioma development, and biomarkers helped understand disease formulate effective immunotherapy for patients. Currently, no B lymphocyte-based prognostic signature was in gliomas. By applying 78 cell lineage-specific genes, we conducted a whole-genome gene expression analysis 782 high derived from three independent datasets by Cox regression risk score method identification,...
Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is an oncofetal highly expressed in fetal tissue and malignant tumors but only rarely within adult benign tissues. The expression of IMP3 esophageal adenocarcinoma (EAC) its precursor lesions including distinctive type Barrett mucosa (BM, intestinal metaplasia) columnar dysplasia (ECD) largely unknown.To characterize the patterns EAC lesions.Samples from 132 cases EAC, 28 ECD (16 high-grade 12 low-grade cases), BM without dysplasia,...
5-fluorouracil (5-FU) is the major chemotherapeutic agent for treatment of colorectal carcinoma, but molecular mechanisms response and resistance are not understood completely. We therefore studied 5-FU dose time course gene expression transcriptome changes in colon carcinoma cell lines that relatively sensitive or resistant to (RKO HT29, respectively) order identify cellular pathways corroborate functions selected pathways. Expression genes polyamine biosynthesis, i.e. ornithine...
Accurate prediction of survival cancer patients is still a key open problem in clinical research. Recently, many large-scale gene expression clusterings have identified sets genes reportedly predictive prognosis; however, those shared few common and were poorly validated using independent data. We developed systems biology-based approach by either combined the protein interaction network (Method A) or alone B) to identify prognostic based on microarray data glioblastoma multiforme compared...
Abstract The invasion inhibitory protein 45 (IIp45) we recently identified was underexpressed in glioblastoma multiforme, the most malignant form of glioma. IIp45 gene is located at chromosome 1p36 where frequent deletions have been reported various types tumors, including gliomas, raising possibility that may be a classic tumor suppressor can inactivated by point mutations. To test this hypothesis, sequenced 59 diffuse glioma samples different grades and histologic subtypes possible...
To investigate the prognostic value of skeletal muscle measured by CT at level fourth thoracic vertebra (T4) in advanced epidermal growth factor receptor (EGFR)-positive non-small cell lung cancer (NSCLC) patients treated with ecotinib.