A5101410720- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Topology Optimization in Engineering
- Composite Structure Analysis and Optimization
- Cancer Cells and Metastasis
- Cancer Treatment and Pharmacology
- Multiple and Secondary Primary Cancers
- Piezoelectric Actuators and Control
- Cell Adhesion Molecules Research
- Cancer-related gene regulation
- Chromatin Remodeling and Cancer
- RNA modifications and cancer
- Single-cell and spatial transcriptomics
- Structural Analysis and Optimization
- Circular RNAs in diseases
- Inflammatory Biomarkers in Disease Prognosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Helicobacter pylori-related gastroenterology studies
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Genetic factors in colorectal cancer
- Protein Kinase Regulation and GTPase Signaling
University of Bristol
2024
Sichuan University
2024
West China Hospital of Sichuan University
2024
Nanjing Medical University
2018-2023
Jiangsu Province Hospital
2018-2023
Yango University
2019
Qingdao Center of Resource Chemistry and New Materials
2018-2019
The People's Hospital of Guangxi Zhuang Autonomous Region
2000
Placenta-specific protein 1 (Plac1) is a cancer/testis antigen that plays critical role in promoting cancer initiation and progression. However, the clinical significance mechanism of Plac1 progression remain elusive. Here, we report an important oncogenic prognostic factor, which physically interacts with Furin to drive breast invasion metastasis. We have shown expression positively correlates stage, lymph node metastasis, hormone receptor status, overall patient survival. Overexpression...
Trastuzumab is a successful, rationally designed therapy that provides significant clinical benefit for human epidermal growth factor receptor-2 (HER2)-positive breast cancer patients. However, about half of individuals with HER2-positive do not respond to trastuzumab treatment because various resistance mechanisms, including but limited to: 1) shedding the HER2 extracellular domain, 2) steric hindrance ( e.g., MUC4 and MUC1), 3) parallel pathway activation (this general mechanism cited in...
Differential regulation of gene transcription contributes to cancer metastasis. We investigated the involvement a Rho GTPase (RhoJ) in breast metastasis focusing on mechanism underlying RhoJ trans-activation by pro-metastatic cues. report that expression was up-regulated malignant cells compared more benign ones. Higher also detected human biopsy specimens advanced stages. depletion attenuated cell migration and invasion vitro vivo. The stimulus TGF-β activated via megakaryocytic leukemia 1...
Breast cancer is the leading cause of death in women worldwide. Long non-coding RNA small nucleolar host gene 1 (SNHG1) has been reported to be involved human diseases, including cancer. Here, we found that SNHG1 expression was significantly upregulated breast tissues and cell lines. We explored function cells using vitro vivo experiments promotes metastasis proliferation. The potential molecular mechanism may involve acting as a sponge miR-193a-5p activate oncogene HOXA1. In summary, our...
Poly (ADP-ribose) polymerase (PARP) inhibitors, which are among the most important breakthroughs in precision medicine, have played a crucial role cancer treatment. Understanding toxicity profiles of different PARP inhibitors will improve strategic treatment clinical practice.PubMed, Cochrane Library, and Web Science were systematically searched to include related studies published English between January 2009 February 2020. Only prospective, phase II III randomized controlled trials...
Abstract Background With life span extending, breast cancer (BC) survivors may face the possibility of developing second primary (SPC) and considerably shorten survivorship. However, little is known about multiple (MPC) patients with nonmetastatic as a first malignancy (BCFPM). Methods Here, we retrospectively analyzed data on BCFPM diagnosed between 2010 2015 from Surveillance, Epidemiology, End Results (SEER) database. The prognostic factors for cancer‐specific survival (BCSS) were...
Cancer-associated fibroblasts (CAFs) are key components in tumor microenvironment (TME). The secreted products of CAFs play important roles regulating cells and further impacting clinical prognosis. This study aims to reveal the relationship between CAF-secreted cytokines breast cancer (BC) by constructing risk signature. We performed three algorithms CAF-related TCGA BC dataset identified five prognosis-related cytokines. Then we used single-cell RNA sequencing (ScRNA-Seq) datasets confirm...
Abstract Background The efficacy and safety of lapatinib plus capecitabine (LC or LX) versus trastuzumab chemotherapy in patients with HER-positive metastatic breast cancer who are resistant to is unknown. Methods We retrospectively analyzed data from began treatment regimens beyond progression (TBP) at eight hospitals between May 2010 October 2017. Results Among 554 had developed resistance trastuzumab, the median PFS (progression free survival) was 6.77 months LX group compared 5.6 TBP...
Although an immense effort has been made to develop a novel biomarker for response trastuzumab, no reliable biomarkers are available guide management, expect HER2. The aim of this study was examine the relationship between microRNA (miRNA) expression and resistance trastuzumab.Differentially expressed miRNAs trastuzumab-resistant trastuzumab-sensitive cell lines were analyzed using microarrays. We performed Gene Ontology Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyses determine...
Lapatinib, targeting the human epidermal growth factor receptor family members HER1 and HER2, has been approved by US Food Drug Administration for use in metastatic HER2-positive breast cancer. However, resistance to lapatinib remains a common challenge Until now, molecular mechanisms of acquired (ALR) have remained unclear. With no definite biomarkers currently known, we aimed screen key ALR. In this research, identified 55 differentially expressed genes (DEGs, 20 upregulated, 35...
Background: Several phase II and pilot studies showed that neoadjuvant nab-paclitaxel-based chemotherapy trastuzumab treatment was effective safe.However, combination of nab-paclitaxel alone with has not been investigated.Methods: This is a retrospective analysis.From July 2009 to June 2014, Patients histologically confirmed, nonmetastatic HER2-positive breast cancer who received 3-week regimen in Guangdong General Hospital were screened.Baseline pathological data blood test results...
The concurrent optimization of topology and fibre orientation is a promising approach to pursue higher strength lighter weight variable-stiffness structures. This paper suggests novel discrete-continuous scheme for the optimization. Considering global convergence, Discrete Material Optimization firstly utilized select dominant angle each element from several predefined candidate angles. However, some regions with multiaxial stress make it difficult definite angles elements. Therefore,...
Several risk scores have been proposed to predict venous thromboembolism (VTE) in hospitalized patients. However, their predictive performances lung cancer patients receiving immune checkpoint inhibitors (ICIs) is unclear. We aimed validate and compare of the Caprini, Padua Khorana ICIs.
The concurrent optimization of topology and fibre orientation is a promising approach to pursue higher strength lighter weight variable-stiffness structures. This paper suggests novel discrete-continuous scheme for the optimization. Considering global convergence, Discrete Material Optimization first utilized select dominant angle each element from several predefined candidate angles. However, some regions with multiaxial stress make it difficult definite angles elements. Therefore,...
DJ-1 is significantly elevated in various malignancies. However, the clinical significance of hormone receptor (HR)-positive (HR+) breast cancer remains unclear. We evaluated expression different databases and validated vitro assay by RT-PCR western blot among HR+ cancer. The correlations between level tumor-immune were calculated. Mutational landscape, enriched signaling pathways, drug sensitivity analyses also assessed high low-expression groups. was upregulated cancer, linked with poor...
Abstract Background: The efficacy and safety of lapatinib plus capecitabine (LC or LX) versus trastuzumab chemotherapy in patients with HER-positive metastatic breast cancer who are resistant to is unknown. Methods: We retrospectively analyzed data from began treatment regimens beyond progression (TBP) at eight hospitals between May 2010 October 2017. Results: Among 554 had developed resistance trastuzumab, the median PFS (progression free survival) was 6.77 months LX group compared 5.6 TBP...
Abstract Background: The efficacy and safety of lapatinib plus capecitabine (LC or LX) versus trastuzumab chemotherapy in patients with HER-positive metastatic breast cancer who are resistant to is unknown. Methods: We retrospectively analyzed data from began treatment regimens beyond progression (TBP) at eight hospitals between May 2010 October 2017. Results: Among 554 had developed resistance trastuzumab, the median PFS (progression free survival) was 6.77 months LX group compared 5.6 TBP...
For origami structures, perforating or cutting slits along creases is an effective method to define fold lines and alleviate stress concentrations at vertices. In this letter we show numerically experimentally that for non-rigid-foldable bellows (e.g. Miura-ori, Kresling patterns) the introduction of small cut-outs vertices results in up order magnitude reduction bellows' stiffness under axial compression. Further, impact nonlinear response, e.g. position a force limit point presence...
Megakaryocytic leukemia 1 (MKL1) acts as a transcription factor in the regulation of immune system and is associated with cancer biology. However, its function infiltrating cells breast has not been explored. Our study aimed to analyze expression MKL1 The Cancer Genome Atlas (TCGA) dataset. aim this was evaluate correlations between expression, cells, control genes. Enriched signaling pathways drug sensitivity analyses were also performed. results indicate that high could predict better...
The concurrent optimization of topology and fibre orientation is a promising approach to pursue higher strength lighter weight variable-stiffness structure. This study proposes novel discrete-continuous scheme for the optimization. Considering global convergence, Discrete Material Optimization (DMO) firstly utilized select dominant angle each element from several predefined candidate angles. However, it still difficult obtain excellent convergence due difficulty in selection materials some...
Abstract Background: The efficacy and safety of lapatinib plus capecitabine (LC or LX) versus trastuzumab chemotherapy in patients with HER-positive metastatic breast cancer who were resistant to is largely unknown. Methods: we retrospectively analyzed began the treatment regimen beyond progression (TBP) at eight hospitals between May 2010 October 2017. Results: Among 554 had developed resistance trastuzumab, median PFS was 6.77 months LX group compared 5.6 TBP (hazard ratio 0.804; 95% CI,...