A5100700401- Metal-Organic Frameworks: Synthesis and Applications
- Acute Myeloid Leukemia Research
- Polyoxometalates: Synthesis and Applications
- Acute Lymphoblastic Leukemia research
- Retinoids in leukemia and cellular processes
- Magnetism in coordination complexes
- Metal complexes synthesis and properties
- Crystal structures of chemical compounds
- Molecular Sensors and Ion Detection
- Advanced Nanomaterials in Catalysis
- Gene Regulatory Network Analysis
- DNA and Nucleic Acid Chemistry
- Spectroscopy and Quantum Chemical Studies
- Redox biology and oxidative stress
- Natural Antidiabetic Agents Studies
- Insect Utilization and Effects
- TGF-β signaling in diseases
- Chromatography in Natural Products
- Covalent Organic Framework Applications
- RNA Interference and Gene Delivery
- Medicinal Plants and Bioactive Compounds
- Biomedical Research and Pathophysiology
- Protein Kinase Regulation and GTPase Signaling
- Bone and Joint Diseases
- stochastic dynamics and bifurcation
Shanghai Sixth People's Hospital
2025
Shanghai Jiao Tong University
2025
Southern Medical University
2016-2024
Nanfang Hospital
2016-2024
Guangdong Pharmaceutical University
2023
Soochow University
2018-2021
RELX Group (United States)
2020
China Pharmaceutical University
2012-2019
Suzhou Research Institute
2018
Nanjing Normal University
2017
Abstract Based on the AMBER polarizable model (ff02), we have reoptimized parameters related to main‐chain (Φ, Ψ) torsion angles by fitting Boltzmann‐weighted average quantum mechanical (QM) energies of important regions (i.e., β, P II , α R and L regions). Following naming convention force field series, this release will be called ff02pol.rl The has been assessed both energetic comparison against QM data replica exchange molecular dynamics simulations short alanine peptides in water. For...
The cytoplasmic regions of the receptors for epidermal growth factor (EGF) and platelet-derived (PDGF) bind activate phospholipase C-γ1 (PLC-γ1) other signaling proteins in response to ligand binding outside cell. Receptor by PLC-γ1 is a function its SH2 domains required factor-induced cell cycle progression into S phase. Microinjection MDCK epithelial cells NIH 3T3 fibroblasts polypeptide corresponding noncatalytic SH2-SH2-SH3 (PLC-γ1 SH2-SH2-SH3) blocked S-phase entry. Treatment with...
A bifunctional cationic MOF showed fast and highly efficient Cr<sub>2</sub>O<sub>7</sub><sup>2−</sup> CrO<sub>4</sub><sup>2−</sup> trapping, photocatalytic activity.
The aim of this study was to identify risk factors for early death (ED) in acute promyelocitic leukemia (APL) patients. Clinical records 49 APL patients who suffered ED were divided into 4 groups: before treatment or within the first 3 days (immediate death; iED group), during at least after commencement (ED treatment), low/intermediate risk, and high-risk groups. White blood cell (WBC) count, cases, prothrombin time (PT) prolongation, international society on thrombosis hemostasis (ISTH)...
Accumulating evidence indicates that enhancer of zeste homolog 2 (EZH2) promotes the metastatic ability solid tumors, but role EZH2 in extramedullary infiltration (EMI) acute myeloid leukemia (AML) has not been thoroughly explored. In present study, we investigated possible association between and EMI. We found messenger RNA (mRNA) protein expression levels AML patients were both significantly higher than idiopathic thrombocytopenic purpura (ITP) patients. Furthermore, a positive correlation...
Rosamultin, a major bioactive constituent from Potentilla anserine L., has antioxidative and hepatoprotective activities. However, its protective effects on cisplatin‐induced acute renal injury the underlying mechanisms remain elusive. In this work, rosamultin could enhance viability of HEK293 cells treated by cisplatin. vivo experiment showed that effectively decreased kidney index, reduced blood urea nitrogen level, urinary protein excretion, ameliorated histopathological damage fibrosis...
Herein, two novel ruthenium(II) complexes coupled by erianin via a flexible carbon chain, [Ru(phen)2(L1-(CH2)4-erianin)](ClO4)2 (L1 = 2-(2-(tri-fluoromethyphenyl))-imidazo [4,5f][1-10]phenanthroline (1) and [Ru(phen)2(L2-(CH2)4-eria)](ClO4)2 (L2 2-(4-(tri-fluoromethyphenyl))-imidazo [4,5f][1,10]phenanthroline (2), have been synthesized investigated as potential G-quadruplex(G4) DNA stabilizer. Both complexes, especially 2, can bind to c-myc G4 with high affinity electronic spectra, the...
Even though phenazines have been extensively reported as anticancer molecules, the molecular target of these compounds is severely lagging behind. Our study consequently focuses on a phenazine analogue (CPUL1) for its potently antitumor activities in initial stage. Along with redox status courses Hep G2 cells, thioredoxin reductase I (TrxR1) was speculated CPUL1. By virtue zymologic, immunological and biological experiments, we demonstrated that TrxR1 could be The knowledge targeting to not...
A multi‐responsive Cd metal–organic framework {[Cd (ttpe)(H 2 O)(ip)]•4H O•DMAC} n ( 1•4H O•DMAC ) was synthesized using hydrothermal method (ttpe = 1,1,2,2‐tetra(4‐(1H‐1,2,4‐triazol‐1‐yl)phenyl)ethylene, ip isophthalate, DMAC N,N ‐dimethylacetamide), and characterized. 1 exhibits a 2D (4,4) network. The luminescent sensing experimrnts showed that as new MOF sensor can detect Cr O 7 2− , CrO 4 MnO − Cu 2+ Ag + Fe 3+ in aqueous solution with simultaneously high efficiency sensitivity....
The present study retrospectively analyzed 96 newly diagnosed acute promyelocytic leukemia (APL) patients with low-intermediate mortality risk to identify the optimum timing initiate cytotoxic chemotherapy following all-trans retinoic acid (ATRA) administration. Based on white blood cell (WBC) at initiation, were divided into three groups: low WBC (WBC count ≤4×109/l), intermediate >4×109/l and <15×109/l) high group ≥15×109/l). According period from ATRA commencement chemotherapy, further...
A Cu(I) coordination polymer, {[Cu4Br(ttpe)3]Br2·(OH)}n (1), was prepared and characterized by single crystal X-ray diffraction analysis, EA, IR, PXRD, luminescence, optical band gaps VB XPS spectra (ttpe = 1,1,2,2-tetrakis[4-(1H-1,2,4-triazol-1-yl)phenyl]ethylene). 1 presents a two-fold interpenetrating (4,12)-connected 3D topology containing the [Cu4Br] tetranuclear copper(I) cluster building block with point symbol of {44.62}3{424.640.82}. Eg, Ev Ec were 2.20, 0.74 −1.46 eV, respectively....
Two Cu(II) coordination polymers, {[Cu(ttpe)0.5(1,3-bdc)]·2H2O·DMAC}n (1) and {[Cu(ttpe)0.5(1,3-bda)]·3H2O}n (2) (ttpe = 1,1,2,2-tetrakis(1,2,4-triazol-1-yl)phenyl)ethylene, 1,3-bdc 1,3-benezenedicarboxylate, 1,3-bda 1,3-benzenediacetate), were hydrothermally prepared characterized. 1 exhibited (4,4)-coordinated 2-D topology with point symbol (3 2 H.J. Park, J. Oh, Kim, Kim. Chem. Commun. (Camb.), 56, 9727 (2020).[Crossref], [PubMed], [Web of Science ®] , [Google Scholar] ·6 ·7 )(3 )2....