A5101909369- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Influenza Virus Research Studies
- Respiratory viral infections research
- COVID-19 epidemiological studies
- Long-Term Effects of COVID-19
- HIV/AIDS Research and Interventions
- SARS-CoV-2 detection and testing
- Vaccine Coverage and Hesitancy
- HIV-related health complications and treatments
- Autoimmune Neurological Disorders and Treatments
- Traditional Chinese Medicine Analysis
- Infectious Encephalopathies and Encephalitis
- Plant chemical constituents analysis
- Hepatitis C virus research
- Aquatic Ecosystems and Phytoplankton Dynamics
- COVID-19 and Mental Health
- Essential Oils and Antimicrobial Activity
- Biosensors and Analytical Detection
- Marine Invertebrate Physiology and Ecology
- Hepatitis B Virus Studies
- Biocrusts and Microbial Ecology
- Cytomegalovirus and herpesvirus research
Gilead Sciences (United States)
2018-2023
Beijing Center for Disease Prevention and Control
2021
Nanjing Municipal Center for Disease Control And Prevention
2020
Merck & Co., Inc., Rahway, NJ, USA (United States)
2018-2019
Nanjing Medical University
2019
Tianjin University of Traditional Chinese Medicine
2014
Regimen adherence remains a major hurdle to the success of daily oral drug regimens for treatment and prevention human immunodeficiency virus (HIV) infection. Long-acting formulations requiring less-frequent dosing offer an opportunity improve allow more forgiving options with regard missed doses. The administration long-acting in clinical setting enables health care providers directly track adherence. MK-8591 (4'-ethynyl-2-fluoro-2'-deoxyadenosine [EFdA]) is investigational nucleoside...
Objectives: We aimed to (1) assess parental hesitancy about category A (Expanded Program on Immunization (EPI)) and B (non-EPI) vaccines, (2) willingness for COVID-19 influenza vaccinations, (3) explore the association of vaccination parents healthcare workers (HCWs). Methods: The study was performed in Wuxi, eastern China between 21 September 2020 17 October 2020. Parents children aged <18 years HCWs were recruited from selected immunization clinics. Vaccine assessed using Strategic...
Abstract Background The duration of humoral and T B cell response after the infection severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains unclear. Methods We performed a cross-sectional study to assess virus-specific antibody memory responses in disease 2019 (COVID-19) patients up 343 days infection. Neutralizing antibodies against receptor-binding domain, spike, nucleoprotein SARS-CoV-2 were measured. Virus-specific analyzed. Results enrolled 59 with COVID-19, including 38...
Lenacapavir (LEN) is a picomolar first-in-class capsid inhibitor of human immunodeficiency virus type 1 (HIV-1) with multistage mechanism action and no known cross resistance to other existing antiretroviral (ARV) drug classes. LEN exhibits low aqueous solubility exceptionally systemic clearance following intravenous (IV) administration in nonclinical species humans. formulated an suspension or PEG/water solution formulation showed sustained plasma exposure levels unintended rapid release...
Doravirine is a novel nonnucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus type 1 infection. In vitro studies were conducted to assess potential drug interactions with doravirine via major drug-metabolizing enzymes and transporters. Kinetic confirmed that cytochrome P450 3A (CYP3A) plays role in metabolism doravirine, ∼20-fold-higher catalytic efficiency CYP3A4 versus CYP3A5. was not substrate breast cancer resistance protein (BCRP) likely organic...
The objective of this study was to construct a novel strategy for the detection severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants using multiplex PCR-mass spectrometry minisequencing technique (mPCR-MS minisequencing). Using nucleic acid sequence SARS-CoV-2 nonvariant and synthetic variant-carrying plasmid, matrix-assisted laser desorption ionization-time flight mass (MALDI-TOF MS) method based on single-base probe extension PCR amplification products established detect 9...
This study aimed to examine childhood vaccination delay, explore the association between delay and parental vaccine hesitancy, assess delays during coronavirus disease (COVID)-19 pandemic in China.This cross-sectional survey was conducted Wuxi City. Participants were recruited from local clinics. Questionnaires used collect information about socio-demographics, immunization clinic evaluations. Vaccination records obtained Jiangsu Information Management System of Cases.Overall, 2728...
GS-CA2, an analog of GS-CA1, is a novel and selective inhibitor HIV-1 capsid function. Safety pharmacokinetics (PK) GS-CA2 currently being evaluated in healthy human subjects. Herein, we present the anti-HIV activity nonclinical PK demonstrating its potential as first-in-class long-acting antiretroviral agent. antiviral was MT-4 cells peripheral blood mononuclear (PBMCs) acutely infected with (IIIb) clinical isolates, respectively. Standard vitro methods were used to characterize compound...
Columbianadin, one of the active coumarins, is isolated from Radix Angelicae pubescentis which has been used as a traditional Chinese medicine for treatment rheumatic diseases thousands years. A fast and sensitive method required determination columbianadin pharmacokinetic studies. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) preeminent analytical tool rapid biomedical analysis.A LC-MS/MS validated to determine concentration in rat plasma after intravenous administration (1, 2.5...
We conducted a longitudinal cohort study of SARS-CoV-2 and influenza rates in childcare centers schools Wuxi, China, collecting 1,760 environmental samples 9,214 throat swabs from 593 students (regardless symptoms) weekly collections during February-June 2023. estimated cumulative infection rate 124.8 (74 episodes)/1,000 persons for 128.2 (76 influenza. The highest was 18 years age, influenza, children 4 age. asymptomatic proportion 59.6% 66.7% influenza; symptomatic lower 16-18-year-olds...
Respiratory pathogen coinfections pose significant challenges to global public health, particularly regarding the intersecting epidemics of COVID-19 and influenza. This study investigated incidences respiratory infectious pathogens in this unique context. We collected throat swab samples from 308 patients with a fever outpatient emergency departments at sentinel surveillance hospitals Xiamen, southeast China, between April May 2023, testing for SARS-CoV-2 26 other pathogens. The coinfection...
Determining the longevity of natural immunity after SARS-CoV-2 infection is critical for understanding immune protection and optimizing vaccine design. Over six months have been passed since emergence COVID-19 in China. We evaluated humoral cellular responses 418 patients infection. 95.9% 98.1% maintained SARS-CoV-2-specific IgG neutralizing antibodies. All severe were positive antibodies had significantly higher titers than mild moderate as well asymptomatic individuals. The a more robust...