A5007813678- Pluripotent Stem Cells Research
- Single-cell and spatial transcriptomics
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- 3D Printing in Biomedical Research
- Advanced Photocatalysis Techniques
- Neurogenesis and neuroplasticity mechanisms
- Glycosylation and Glycoproteins Research
- Reconstructive Surgery and Microvascular Techniques
- Catalytic Processes in Materials Science
- Memory and Neural Mechanisms
- Reconstructive Facial Surgery Techniques
- CRISPR and Genetic Engineering
- Neuroendocrine regulation and behavior
- Cellular transport and secretion
- Cell Image Analysis Techniques
- Mast cells and histamine
- Nanomaterials for catalytic reactions
- Cellular Mechanics and Interactions
- Ear and Head Tumors
- Workplace Health and Well-being
- Employment and Welfare Studies
- Facial Nerve Paralysis Treatment and Research
- Congenital heart defects research
Stanford University
2018-2024
Organogenesis (United States)
2019-2024
Jichi Medical University
2024
The University of Tokyo
2011-2024
Neurosciences Institute
2020-2023
Neuroscience Institute
2022-2023
Tohoku Medical and Pharmaceutical University
2013-2022
Komatsu (Japan)
2022
Matsumoto Dental University
2021
Tohoku University
2008-2021
Abnormal behaviors in individuals with neurodevelopmental disorders are generally believed to be irreversible. Here, we show that voluntary wheel running ameliorates the abnormalities sociability, repetitiveness, and anxiety observed a mouse model of disorder induced by maternal immune activation (MIA). Exercise activates portion dentate granule cells, normalizing density hippocampal CA3 synapses, which is excessive MIA-affected offspring. The synaptic surplus MIA offspring deficits synapse...
Morphogens choreograph the generation of remarkable cellular diversity in developing nervous system. Differentiation stem cells toward particular neural cell fates vitro often relies upon combinatorial modulation these signaling pathways. However, lack a systematic approach to understand morphogen-directed differentiation has precluded many populations, and knowledge general principles regional specification remain in-complete. Here, we developed an arrayed screen 14 morphogen modulators...
Abstract Neural circuits connecting the cerebral cortex, basal ganglia and thalamus are fundamental networks for sensorimotor processing their dysfunction has been consistently implicated in neuropsychiatric disorders 1-9 . These recursive, loop have investigated animal models by clinical neuroimaging, however, direct functional access to developing human neurons forming these limited. Here, we use pluripotent stem cells reconstruct an vitro cortico-striatal-thalamic-cortical circuit...
A simple and unique route to synthesize nanosize Pd particles using a zeolite support including single-site Ti oxide moiety (TS-1) under UV-light irradiation has been developed. By the photoassisted deposition (PAD) method, precursor can be deposited directly on photoexcited tetrahedrally coordinated within frameworks from an aqueous solution of Pd. The subsequent reduction with H2 generates nanosized metal narrow size distribution (PAD-Pd/TS-1). Characterization by XAFS TEM analysis...
Prevention of relapses is a major challenge in treating anxiety disorders. Fear reinstatement can cause relapse spite successful fear reduction through extinction-based exposure therapy. By utilising contextual fear-conditioning task mice, we found that was accompanied by decreased c-Fos expression the infralimbic cortex (IL) with synaptic input and enhanced medial subdivision central nucleus amygdala (CeM). Moreover, IL dopamine plays key role reinstatement. A reinstatement-inducing...
The oral microbiome plays an important role in the human microbial community and maintaining health of individual. Imbalances may contribute to systemic diseases. progression periodontal disease is closely related growth bacteria, such as Porphyromonas gingivalis, cavity. However, pathogen mechanism specific remains unknown. This study aimed identify bacteria associated with by focusing on hemolytic bacteria. Unstimulated saliva samples were collected from ten periodontitis patients five...
Abstract Abnormalities in crosstalk between the thalamus and cerebral cortex are thought to lead severe neuropsychiatric disorders, such as epilepsy psychotic disorders. Pathogenic variants CACNA1G gene, which encodes α1G subunit of thalamus-enriched T-type voltage-gated calcium channel CaV3.1, associated with absence seizures, intellectual disability, schizophrenia, but cellular circuit level consequences these genetic humans remain unknown. Here, we developed an vitro human assembloid...
Organoids and assembloids have emerged as a promising platform to model aspects of nervous system development. Longterm, minimally-invasive recordings in these multi-cellular systems are essential for developing disease models. Current technologies, such patch-clamp, penetrating microelectrodes, planar electrode arrays substrate-attached flexible electrodes, do not, however, allow chronic recording organoids suspension, which is necessary preserve their architecture. Inspired by the art...
BACKGROUND: Pendred syndrome is often associated with inner ear malformations, especially enlarged vestibular aqueduct (EVA). Recently, mutations in the gene (PDS) have been reported patients EVA, addition to those classical syndrome. OBJECTIVE: The aim of this study was investigate genotype-phenotype correlations PDS. METHODS: Each 21 exons and flanking splice regions PDS analysed by direct DNA sequencing nine EVA; allele-specific amplification performed confirm mutation. Genetic analyses...
Mental disorders create a considerable burden to society. Previous studies have shown that productivity loss constitutes the largest proportion of total societal burden. For depression and anxiety disorders, in particular, more than half associated occurs workplace. Many previous clarified risk factors for relapse/recurrence mental health care settings. However, repeated sick leave among prevalent workplace not yet been adequately evaluated.The objective this study was investigate which...
ACAP3 (ArfGAP with coiled-coil, ankyrin repeat and pleckstrin homology domains 3) belongs to the ACAP family of GAPs (GTPase-activating proteins) for small GTPase Arf (ADP-ribosylation factor). However, its specificity isoforms physiological functions remain unclear. In present study, we demonstrate that plays an important role in neurite outgrowth mouse hippocampal neurons through GAP activity specific Arf6. primary cultured neurons, knockdown abrogated outgrowth, which was rescued by...