A5007124067- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- RNA modifications and cancer
- RNA Research and Splicing
- Ruminant Nutrition and Digestive Physiology
- RNA and protein synthesis mechanisms
- Preterm Birth and Chorioamnionitis
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- Cancer-related gene regulation
- interferon and immune responses
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Animal Nutrition and Physiology
- Immune Cell Function and Interaction
- Horticultural and Viticultural Research
- Viral Infections and Immunology Research
- Listeria monocytogenes in Food Safety
- Gestational Trophoblastic Disease Studies
- Neonatal Respiratory Health Research
- COVID-19 Impact on Reproduction
- Hippo pathway signaling and YAP/TAZ
Cardiff University
2024
Beijing Friendship Hospital
2024
Peking Union Medical College Hospital
2024
Harbin Medical University
2024
Second Affiliated Hospital of Harbin Medical University
2024
Central South University
2024
Shanghai Jiao Tong University
2013-2024
International Peace Maternity & Child Health Hospital
2016-2024
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2023-2024
Tianjin University of Traditional Chinese Medicine
2023-2024
Microplastics (MPs), which are emerging as a new type of environmental pollutants, have raised great concerns regarding their threats to human health. A successful pregnancy depends on the sophisticated regulation maternal-fetal immune balance, but risks polystyrene MP (PS-MP) exposure in early remain unclear. In this study, we exposed C57BL/6-mated BALB/c mice PS-MP particles and used flow cytometry explore towards system. Herein, allogeneic mating murine model showed an elevated embryo...
The receptor Notch and its ligands of the Delta/Serrate/LAG2 (DSL) family are central components in pathway, a fundamental cell signaling system that regulates pattern formation during animal development. Delta is directly ubiquitinated by Drosophila Xenopus Neuralized,and zebrafish Mind bomb, two unrelated RING-type E3 ubiquitin ligases with common abilities to promote endocytosis activity. Although orthologs both Neuralized bomb found most metazoan organisms, their relative contributions...
Hybridization in bovines is practiced with the main aim of improving production performance, which may imply microbial variations rumen from parental breed cross to their progeny. Besides, interactions offspring sex terms bacteria are not clear. This study aims evaluate bacterial communities different breeds and sexes, correlations among fattening serum biochemical parameters, fermentation. Forty-two 19.2 ± 0.67-month-old beef cattle (390 95 kg initial body weight) comprising two genetic...
Abstract Background In many animals, the first few hours of life proceed with little or no transcription, and developmental regulation at these early stages is dependent on maternal cytoplasm rather than zygotic nucleus. Translational control critical for Drosophila embryogenesis exerted mainly gene level. To understand post-transcriptional during embryonic development, we used sucrose polysomal gradient analyses GeneChip analysis to illustrate translation profile individual mRNAs. Results...
Polyphenol-rich grape pomace (GP) represents a valuable processing by-product with considerable potential as sustainable livestock feed. This study aimed to investigate the effects of different levels GP on growth performance and nitrogen utilization efficiency, antioxidant activity, rumen rectum microbiota Angus bulls. Thirty bulls were allocated three dietary treatments according completely randomized design: 0% (G0), 10% (G10), 20% (G20) corn silage dry matter replaced dried matter. The...
Spinal cord injury (SCI) is a severe traumatic lesion of central nervous system (CNS) with only limited number restorative therapeutic options. Diosgenin glucoside (DG), major bioactive ingredient Trillium tschonoskii Max., possesses neuroprotective effects through its antioxidant and anti-apoptotic functions. In this study, we investigated the benefit underlying mechanisms DG treatment in SCI. We found that Sprague-Dawley rats SCI, expressions autophagy marker Light Chain 3 (LC3) Beclin1...
Maternal immune system tolerance to the semiallogeneic fetus is critical for a successful pregnancy. Studies have shown that myeloid-derived suppressor cells (MDSCs) play an important role in maintaining feto-maternal tolerance. However, mechanisms remain poorly understood.Flow cytometry was used evaluate percentage of MDSCs allogeneic-normal-pregnant mouse model during different periods gestation. We further assessed and their subtypes (granulocytic [GR-MDSCs] monocytic [MO-MDSCs])...
Tristetraprolin (TTP) regulates the stability of multiple targets that have important biological roles. However, role TTP in trophoblasts at maternal-fetal interface remains poorly understood. We demonstrated was upregulated placental from patients with recurrent miscarriages (RMs). Immunofluorescence and immunoblotting analyses indicated redistributed nucleus to cytoplasm RMs. Trophoblast invasion proliferation repressed by overexpression enhanced knockdown. Interestingly, knockdown...
Abstract A successful pregnancy requires sophisticated regulation of uterine microenvironment to guarantee the existence semi-allogeneic conceptus without immune rejection. T follicular regulatory (Tfr) cells exert a suppressive effect on Tfh-cell expansion, B-cell response, and antibody production. Although accumulating evidence has demonstrated that dysregulations Tfr can bring various immunological diseases, their immunomodulatory roles during still remain unheeded. Herein, we introduced...
The ‘Huangguan’ pear is one of the high-quality cultivars produced in China. However, bagged fruit often suffers from peel browning spots after rain during their mature period. In this study, an effort to discover impact bagging treatments on occurrence and quality, fruits were covered by single-layer, two-layer, or triple-layer paper bags six weeks reaching full bloom. results showed that characterized smooth surfaces reduced lenticels compared with unbagged ones. two-layer had yellow/green...
A large proportion of women experience depression during the postpartum period. Few studies have investigated use mobile technology to prevent in women. This study preliminary effectiveness CareMom program, a new app-based cognitive behavioral therapy on reducing depressive symptoms mothers very early period via pilot randomized controlled study. The participants were recruited birth hospitalization (within 3 days after giving birth) and waiting-list control groups. Over four-week...
Total saponins from Trillium tschonoskii Maxim (TSTT), a bioactive component of local natural herbs in the Enshi area, China, have been demonstrated to functions restoring cognitive capacity and promoting axonal regeneration post-stroke, but mechanism this process remains unclear. The hippocampus is critical tissue for controlling learning memory capacity, sonic hedgehog (Shh) signaling pathway plays major role patterning synaptic plasticity hippocampal neural circuits. Therefore, we aimed...
The objective of this study was to evaluate the effects isopropyl ester 2-hydroxy-4-(methylthio)-butyrate acid (HMBi) on ruminal and cecal fermentation, microbial composition, nutrient digestibility, plasma biochemical parameters, growth performance in finishing beef cattle. experiment conducted for 120 days by a complete randomized block design. Sixty 24-month-old Angus steers (723.9 ± 11.6 kg) were randomly assigned one flowing three treatments: basal diet (the concentrate: 7.6...
Problem Human pregnancy is a complex biological process, and spontaneous abortion the most common complication of pregnancy. Lnc RNA s have been identified that play key roles in variety human diseases. Recently, lnc PVT 1 was reported to relate pathogenesis progression However, role underlying mechanism trophoblast cell dysfunction remain largely unknown. Method study The effects , miR‐424, eIF 5A on HTR 8 cells villi tissues from or induced abortions were investigated using CCK ‐8 assay,...
Decidual CD8+ (dCD8) T cells have been proposed to play important roles in immune protection against the invading pathogens and tolerance toward growing semi-allogeneic fetus during early pregnancy. However, their phenotypic functional characteristics remain poorly defined. Here, we performed first analysis of transcriptional alternative splicing (AS) signatures for human first-trimester dCD8 using high-throughput mRNA sequencing. Our data revealed that distinct AS landscapes as compared...
Preeclampsia is a gestational hypertensive disease; however, preeclampsia remains poorly understood. Bioinformatics analysis was applied to find novel genes involved in the pathogenesis of and identified CLDN1 as one most differentially expressed when comparing patients with healthy controls. The results qRT-PCR, Western blotting immunohistochemistry experiments demonstrated that significantly downregulated chorionic villi samples from preeclampsia. Furthermore, knockdown HTR-8/SVneo cells...