A5100623618- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Breast Lesions and Carcinomas
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Breast Implant and Reconstruction
- Lung Cancer Treatments and Mutations
- Global Cancer Incidence and Screening
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Chronic Myeloid Leukemia Treatments
- Ocular Oncology and Treatments
- Caveolin-1 and cellular processes
- Peroxisome Proliferator-Activated Receptors
- Lipid metabolism and disorders
- interferon and immune responses
- Ubiquitin and proteasome pathways
Henan Cancer Hospital
2025
Zhengzhou University
2018-2025
First Affiliated Hospital of Xi'an Jiaotong University
2017-2023
Second Affiliated Hospital of Jilin University
2007-2021
Second Affiliated Hospital of Nanchang University
2021
Nanchang University
2021
Entasis Therapeutics (United States)
2020
Xinjiang Medical University
2020
Fu Wai Hospital
2020
First Affiliated Hospital of Kunming Medical University
2020
Sequential combination bypass therapy (SCBT) is an effective treatment option for haemophilia patients with inhibitors; however, its safety, efficacy, and cost have largely yet to be systematically evaluated. To address this question, we retrospectively analyzed the medical records of 14 high titer inhibitors who underwent surgery. The were treated two SCBT regimens by optimizing doses recombinant activated factor VII (rFVIIa) prothrombin complex concentrate (PCC). effectiveness safety In...
Tristetraprolin (TTP) regulates the stability of multiple targets that have important biological roles. However, role TTP in trophoblasts at maternal-fetal interface remains poorly understood. We demonstrated was upregulated placental from patients with recurrent miscarriages (RMs). Immunofluorescence and immunoblotting analyses indicated redistributed nucleus to cytoplasm RMs. Trophoblast invasion proliferation repressed by overexpression enhanced knockdown. Interestingly, knockdown...
Purpose To investigate the distribution of Ki67+ cells in breast cancer relation to clinical-pathological parameters and prognosis. Materials Methods Ki67 expression status was detected 1,086 specimens using immunohistochemistry staining examining relationship between cells' location. Subsequently, prognosis were determined. Results In total, protein found 781 (71.92%) specimens. Among cases, 461 defined as diffuse type 320 borderline type. After universal correlation analysis, significant...
Long-noncoding RNAs (lncRNAs) have been shown to participate in oncogenesis across a variety of cancers and may represent novel therapeutic targets. However, little is known about the role lncRNAs basal-like breast cancer (BLBC), aggressive form with no molecularly defined target. To examine whether altered lncRNA expression contributes phenotype characteristic BLBC, we performed comparative analysis BLBC versus non-BLBC using microarray profiling RNA sequencing primary cancer. We identified...
Understanding the bone and musculoskeletal system is essential to maintain health quality of life our aging society. Mesenchymal stem cells (MSCs) can undergo self-renewal differentiate into multiple tissue types including bone. We demonstrated that BMP9 most potent osteogenic factors although molecular mechanism underlying action not fully understood. Long noncoding RNAs (lncRNAs) play important regulatory roles in many physiological and/or pathologic processes. Here, we investigated role...
Endothelial inflammation and dysfunction are critical to the process of atherosclerosis. Emerging evidence demonstrates that upregulation miR-200a reduces VCAM-1 expression prevents monocytic cell adhesion onto aortic endothelium. However, limited information is available about role microRNA-200a (miR-200a) in facilitating atherosclerotic lesion formation. We investigated anti-inflammatory anti-atherosclerotic actions miR-200a. Human umbilical vein endothelial cells (HUVECs) were cultured...
The poor therapy response and prognosis of esophageal cancer has made it one the most malignant carcinoma, complicated multidisciplinary treatment failed to achieve a long-term disease-free survival. To diagnose at an earlier stage, improve effect anticancer would therapeutic efficacy. After retrospective analysis samples patients who received esophagectomy, we found relevance between ratio either ALDH1 or CD133-positive stem cells 2-year recurrence. Higher ratios indicated later clinical...
// Guodong Xiao 1, * , Xiang Li Gang Boxiang Zhang 1 Chongwen Xu 2 Sida Qin Ning Du Jichang Wang 3 Shou-Ching Tang 4, 5 Jing Hong Ren Ke Chen 6 and Xin Sun Department of Thoracic Surgery Oncology, The Second Surgery, Cancer Center, First Affiliated Hospital Xi'an Jiaotong University, 710061, China Otorhinolaryngology, Vascular Endovascular 4 Breast Program Interdisciplinary Translational Research Team, Georgia Regents University Augusta, 30912, United States Tianjin Medical Institute...
Lung carcinoma tops the categories of cancer related motility, and has been treated as main threat to human health. The functions mechanism FBXW7 controlled lung stem cells' signatures is barely unknown, miR-367 regulations via Wnt signaling have not explored. Cancer cells either ALDH1+ or CD133+ phenotype were found be referred advanced stages in patients with NSCLC (non-small cell carcinoma). To study roles miR-367, we greater level was reserved than that paired adjacent normal tissues,...
Abstract T cell factor 1 (TCF-1) is expressed in both developing and mature cells has been shown to restrain cell–mediated Th17 responses by inhibiting IL-17 expression. However, it not clear when TCF-1 required vivo the magnitude of peripheral what molecular mechanisms responsible for TCF-1–regulated gene expression are. In this study, we showed that conditional deletion at early but later CD4+CD8+ double-positive stage mice enhanced differentiation aggravated experimental autoimmune...
CASC8 lncRNA has been proven to be oncogenic in a variety of cancers, but its role other types cancer remains unclear. This study was investigate the retinoblastoma (Rb).RT-qPCR performed determine expression and miR34a paired Rb nontumor tissue. Overexpression cells achieved evaluate interaction between them. Methylation-specific PCR used analyze effect overexpression on MIR34A gene methylation. CCK8 assays were cell proliferation.The results showed that upregulated downregulated Moreover,...
The aim of the present study was to determine effect 60% normobaric oxygen (NBO) on neurological function, brain edema and expression hypoxia‑inducible factor‑1α (HIF‑1α), aquaporin 4 (AQP4) Na+/H+ exchanger 1 (NHE1) in a rat model cerebral ischemia‑reperfusion injury. Male Sprague‑Dawley rats underwent transient focal ischemia via right middle artery occlusion (MCAO) for 120 min followed by 48 h reperfusion. were exposed NBO at 60 100% or no treatment during reperfusion h. Neurological...
Abstract Ulcerative colitis (UC) is a prevalent relapsing-remitting inflammatory bowel disease whose pathogenetic mechanisms remain elusive. In the present study, colonic biopsies samples from three UC patients treated in Traditional Chinese Medicine Hospital and healthy controls were obtained. The genome-wide mRNA lncRNA expression of profiled through Agilent gene microarray. Moreover, DNA methylation dataset normal colon tissues was also downloaded GEO for collaborative analysis....
Tumor-associated dendritic cells (DCs) often induce T cell anergy or deletion and regulatory instead of antitumor immunity. Although many tumor-associated Ags have been found, there is still no effective vaccine for cancer. Thus, novel rational strategies to enhance the immunogenicity cancer-specific are needed. Chromosome 1 open reading frame 190 (c1orf190), a gene that encodes 239-aa hypothetical protein contains multiple kinase phosphorylation sites, has wide relationship with signaling...
Atherosclerosis is a multifactorial chronic disease that major cause of death and injury worldwide. Apoptosis endothelial cells (ECs) serves an important role in the occurrence development atherosclerosis. MicroRNAs (miRNAs) serve key atherosclerosis though regulating function ECs. At present, miRNA-144-5p (miR-144-5p) unclear. The aim this study was to investigate effect miR-144-5p on oxidized low-density lipoprotein (ox-LDL)-stimulated human umbilical vein (HUVECs). Results from present...
This study aimed to evaluate the clinical usefulness of postoperative surveillance by ultrasound (PSU) in patients after breast cancer surgery. In this retrospective study, 324 with mastectomy were included between January 2006 and December 2008. The final-positive lesions (FPL) diagnosed according results cytopathology, imaging examinations. outcome evaluations sensitivity (SS), specificity (SC), accuracy for FPL (UAFPL), positive predictive value (PPV) mastectomy. A total 5117 examinations...
This study aimed to explore the clinical usefulness of ultrasound-guided fine needle aspiration cytology (USG-FNAC) for evaluation axillary lymph nodes in patients with early stage breast cancer (BC) among Chinese Han female population. Around 124 BC were included this retrospective study. All underwent USG-FNAC (group A). Patients proven metastasis also node dissection (ALND) B). In addition, sentinel biopsy (SLNB) was performed 2 5 hours prior surgery. The sensitivity, specificity,...
To determine the most suitable strategy in treating patients with invasive breast cancer from Northwest China. Lower recurrence score (RS) correlated lower ratio. Patients having a medium-high 21-gene RS who received adjuvant therapy presented risk. Younger results (⩾31) tended to accept more often, however, those intermediate were inclined wait and did not receive chemotherapy. These suggested that RS-based precision medicine will allow individualized diagnosis treatment, resulting better...