A5022359679- Blood Coagulation and Thrombosis Mechanisms
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Platelet Disorders and Treatments
- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- Mechanical Circulatory Support Devices
- Heparin-Induced Thrombocytopenia and Thrombosis
- Orthopaedic implants and arthroplasty
- Cardiac Valve Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
- Inflammatory mediators and NSAID effects
- Cardiac and Coronary Surgery Techniques
- Orthopedic Infections and Treatments
- Cardiac Arrest and Resuscitation
- Eicosanoids and Hypertension Pharmacology
- Cell Adhesion Molecules Research
- HIV Research and Treatment
- Cardiac Arrhythmias and Treatments
- Cardiovascular Disease and Adiposity
- Tracheal and airway disorders
- Acute Myocardial Infarction Research
- Systemic Sclerosis and Related Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immune Response and Inflammation
Sendai Medical Center
2024-2025
Osaka City General Hospital
2025
Miyagi Prefectural Hospital Organization
2021
Sun Pharma (Japan)
2021
Tochigi Cancer Center
2021
Takeda (Japan)
1996-2018
RELX Group (United States)
2018
London Borough of Camden
2018
Yokkaichi Social Insurance Hospital
2011-2017
Yokohama City University
2014-2017
BACKGROUND Nonsteroidal antiinflammatory drugs inhibiting cyclooxygenase (COX) enzyme activity in both its constitutive (COX-1) and inducible (COX-2) isoforms were shown also to inhibit the development of colon carcinoma animal models. COX-2 is an inducer angiogenesis new blood vessels. The expression COX-1 prostate tissues from patients with was investigated using reverse transcriptase-polymerase chain reaction (RT-PCR) immunohistochemistry. METHODS Tumor specimens obtained 28 (PC)...
Background Vascular injury activates various kinds of genes, including proto-oncogenes, growth factors, and extracellular matrix proteins. However, the significance activation these genes in neointimal formation is poorly understood. Angiotensin II type 1 (AT ) receptor antagonist shown to prevent after vascular injury, although mechanism unclear. To understand molecular thickening, we examined effects AT blockade on gene expression transforming factor–β (TGF-β ), proteins injury. Methods...
Pharmacological profiles of a novel specific platelet activating factor (PAF) antagonist, TCV-309 (3-bromo-5-[N-phenyl-N-[2-[2- (1,2,3,4-tetrahydro-2-isoquinolycarbonyloxy)ethyl] carbamoyl]ethyl] carbamoyl]-1-propylpyridinium nitrate] and its beneficial effects in shock were examined. specifically inhibited PAF-induced aggregation rabbit human platelets, [3H]PAF binding to microsomes with IC50 values 33, 58 27 nM, respectively. It was as potent WEB 2086 more than CV-6209 CV-3988. did not...
The aim of the present study was to evaluate natural course acute incomplete stent apposition (ISA) after second-generation everolimus-eluting (EES) when compared with first-generation sirolimus-eluting (SES) by using optical coherence tomography (OCT).From OCT substudy RESET trial, we identified 77 patients (EES = 38 and SES 39) who successfully underwent serial examination at post-stenting 8-12-month follow-up. presence ISA assessed in images, distance measured from centre strut blooming...
症例は68歳男性.急性発症した下腿浮腫を主訴に前医を受診し,高血圧,高血糖,低カリウム血症が確認された.血中ACTHとコルチゾールは高値を示しており,Cushing症候群疑いとして当院に紹介となった.胸部CTで右肺上葉に8 mmの結節を認め,ACTH産生腫瘍が強く疑われ,右上葉切除+リンパ節郭清(ND2a-2)を施行した.病理組織学的に定型肺カルチノイドと診断され,術後に血中ACTH値は著明に低下し,症状の改善が得られた.術後14ヵ月現在,再発なく経過している.
Coagulation enzyme factor Xa (FXa) is a particularly promising target for the development of new anticoagulant agents. We previously reported imidazo[1,5-c]imidazol-3-one derivative 1 as potent and orally active FXa inhibitor. However, it was found that predominantly undergoes hydrolysis upon incubation with human liver microsomes, specific metabolic pathway made difficult to predict pharmacokinetics. To address this issue, our synthetic efforts were focused on modification moiety metabolite...
Alterations of the structure and/or amount glycans present on proteins are associated with many diseases. We previously demonstrated that changes in N-glycans alter Aβ production. In study, we focused relationship between Alzheimer's disease (AD) and O-glycan, another type glycan. The UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family functions first step mucin-type O-glycan synthesis. Analysis expression GalNAc-Ts human brain using real-time PCR...
Coronary computed tomography angiography (CCTA) not only provides information regarding luminal stenoses but also allows for visualization of mural atheromatous changes (coronary plaques).We sought to elucidate whether plaques seen on CCTA enable prediction 2-year outcomes in patients with suspected and known coronary artery disease (CAD).Of 3015 who underwent CCTA, the images clinical courses 2802 were independently analyzed. The primary endpoint was composite all-cause death acute...
Mucosal secretory IgA is considered to have an important role in the prevention of human immunodeficiency virus type 1 (HIV-1) transmission through sexual intercourse. Therefore, substances that induce HIV-1-specific antibody genital tract may become promising candidates for prophylactic vaccine against HIV-1 infection. We previously reported concanavalin A-immobilized polystyrene nanospheres (Con A-NS) could efficiently capture particles and gp120 antigens on their surface intravaginal...
We have previously reported that concanavalin A-immobilized polystyrene nanospheres (Con A-NS) could efficiently capture HIV-1 particles and intranasal immunization with inactivated HIV-1-capturing (HIV-NS) induced vaginal anti-HIV-1 IgA antibody response in mice. In this study, to evaluate the protective effect of immunization, each three macaques was intranasally immunized Con A-NS or simian/human immunodeficiency virus KU-2-capturing (SHIV-NS) then intravaginally challenged a pathogenic...
Agaricus blazei Murill is an edible fungus used in traditional medicine, which has various well-documented medicinal properties. In the present study, we investigated effects of hemicellulase-derived mycelia extract (Agaricus fraction H: ABH) on immune system. First, examined cytokine-inducing activity ABH human peripheral mononuclear cells (PBMC). The results indicated that induced expression IL-12, a cytokine known to be critical regulator cellular responses. Flow cytometric analysis...
Inhibitory effects of TCV-116 [(+-)-1-(cyclohexyloxycarbonyloxy)ethyl2-ethoxy-1-[[2'-(1H- tetrazol-5- yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate], a novel angiotensin II AT1 subtype receptor antagonist, on the proliferation vascular smooth muscle cells and impairment endothelium-dependent relaxation were examined in rat carotid balloon injury model. DNA content artery was increased 3 days after reached plateau 14 injury. Beneficial this model Oral administration at 1 10...
Based on the lead tetrapeptide RGDF, two possible non-peptide glycoprotein (GP) IIb-IIIa antagonists possessing an (S)-2-oxopiperazine-3-acetic acid moiety as a scaffold incorporating indispensable Asp fragment were prepared, and (S)-4-[[trans-[4-(guanidinomethyl)-cyclohexyl]carbonyl]glycyl]-2- oxopiperazine-1,3-diacetic acid, 1a, was identified potential lead. A series of 3-substituted 2-oxopiperazine-1-acetic acids bearing Arg-Gly equivalent at 4-position prepared evaluated for their...
Heme oxygenase consists of two structurally related isozymes, heme oxygenase‐1 and oxygenase‐2, each which cleaves to form biliverdin, iron carbon monoxide. Expression is increased or decreased depending on cellular microenvironments, whereas little known about the regulation oxygenase‐2 expression. Here we show that hypoxia (1% oxygen) reduces expression levels mRNA protein after 48 h incubation in human cell lines, including Jurkat T‐lymphocytes, YN‐1 K562 erythroleukemia, HeLa cervical...
To establish an effective tool for the prevention of HIV-1 transmission, lectin-immobilized polystyrene nanospheres were synthesized and examined their capture activity. When concanavalin A (Con A) was immobilized on surface (400 nm in diameter) with poly(methacrylic acid) branches incubated suspension at room temperature 60 min, A-NSs) achieved a >3.3 log 2.2 reduction viral infectivity (IIIB strain) concentration 2 0.5 mg/ml, respectively. Meanwhile, Con A-free nanospheres, which not A,...
Silicone rubber hollow fiber membrane produces an ideal gas exchange for long-term ECMO due to nonporous characteristics. The extracapillary type silicone oxygenator having ultrathin was developed pediatric application. test modules were compared conventional coil-type modules. In vitro experiments demonstrated a higher O2 and CO2 transfer rate, lower blood flow resistance, less hemolysis than the This combined with Gyro C1E3 centrifugal pump, three ex vivo conducted simulate V-A condition....
Background: Inhibition of the renin-angiotensin system (RAS) with angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) can suppress left ventricular (LV) remodeling after acute myocardial infarction (AMI), possibly through modifications matrix metalloproteinase (MMP)-9. Whether LV is suppressed in association MMP-9 suppression post-AMI/-percutaneous coronary intervention (PCI) patients treated ACE inhibitor and/or ARB was examined. The presence any...
Background: A previous study reported that amlodipine retarded coronary plaque progression in patients with artery disease. The goal of this multicenter was to determine which calcium-channel blockers (CCBs) other than attenuated the volume (PV) accessed by intravascular ultrasound (IVUS). Methods and Results: ALPS-J a prospective, randomized open-label conducted at 5 centers. Patients who had hypertension were scheduled for intervention enrolled. Subjects randomly assigned receive 16mg/day...
Objectives. The purposes of this study were 1) to examine the changes in hip joint center (HJC) position and femoral offset (FO) after total arthroplasty (THA) 2) investigate effects HJC FO on isometric abductor muscle strength. Methods. We evaluated 51 patients who underwent unilateral primary THA. FO, horizontal vertical distances from tip teardrop measured strength was measured. Results. affected side moved medially postoperatively compared with that unaffected (p < 0.05), reconstructed...