A5057062166- Nutrition and Health in Aging
- Cancer survivorship and care
- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Childhood Cancer Survivors' Quality of Life
- Cancer-related cognitive impairment studies
- Body Composition Measurement Techniques
- Cardiovascular and exercise physiology
- Hemodynamic Monitoring and Therapy
- Venous Thromboembolism Diagnosis and Management
- Pancreatic and Hepatic Oncology Research
- Muscle Physiology and Disorders
- Cancer Treatment and Pharmacology
- Innovation Policy and R&D
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Mitochondrial Function and Pathology
- Muscle metabolism and nutrition
- Advanced X-ray and CT Imaging
- BRCA gene mutations in cancer
- Diagnosis and Treatment of Venous Diseases
- Sports Performance and Training
- Infrared Thermography in Medicine
- Medical Imaging and Pathology Studies
- Parathyroid Disorders and Treatments
- Metabolism, Diabetes, and Cancer
Hamm-Lippstadt University of Applied Sciences
2017-2020
Philipps University of Marburg
2019
Heidelberg University
2005-2012
National Center for Tumor Diseases
2007-2012
German Cancer Research Center
2004-2012
University Hospital Heidelberg
2011
Bracco (Germany)
2011
German Sport University Cologne
2010
DKFZ-ZMBH Alliance
2004-2009
Dramatic weight loss is an often underestimated symptom in pancreatic cancer patients. Cachexia- defined as unintended of stable exceeding 10%--is present up to 80% patients with the upper gastrointestinal tract, and has a significant influence on survival. The aim study was show multiple systemic effects cachexia patients, terms resection rate, pulmonary function, amount fat muscle tissue, well changes laboratory parameters.In cancer, clinical appearance documented, including loss....
Cancer-related cachexia is an obscure syndrome leading to muscle wasting, reduced physical fitness and quality of life. The aim this study was assess morphology, metabolism, microcirculation in skeletal muscles patients with cancer-related compare these data matched healthy volunteers.In 19 cancer-induced age-, gender-, body-height-matched volunteers body composition aerobic capacity (VO(2max)) were analyzed. Skeletal fiber size capillarization evaluated biopsies the vastus lateralis muscle....
The purpose of this study was to develop a clinically applicable examination method assess perfusion the skeletal muscle using contrast-enhanced ultrasonography (CEUS) analyzing replenishment kinetics microbubbles.Power Doppler sonography (7 MHz) after intravenous bolus injection 10 mL microbubble contrast agent used repeatedly examine right biceps at rest and defined exercise in healthy volunteers. Parameters perfusion, such as local blood volume, flow velocity, were calculated by modified...
Objective: This feasibility study was performed to assess whether dynamic contrast-enhanced ultrasound (CEUS) and transient arterial occlusion are able detect alterations in the microvascular perfusion reserve patients suffering from peripheral disease (PAD) comparison with healthy volunteers. Materials Methods: Twenty PAD, Rutherford classification grade I, category III (mean age, 64 years; mean height, 173 cm; weight, 81.8 kg), 20 volunteers 50 174 77.8 kg) participated study....
Objective. The purpose of this study was to compare skeletal muscle perfusion measured by contrast-enhanced ultrasonography (CEUS) with microvascular density in biopsies. Methods. Power Doppler sonography after intravenous bolus injection Levovist (SH U 508A; Schering AG, Berlin, Germany) used examine vastus lateralis 23 healthy volunteers. Local blood volume (B), flow velocity (v), and (f) were calculated analyzing replenishment kinetics. CEUS compared vascularization biopsy samples from...
(CG). Patients in the IG participated a 60-min session of resistance training twice week for 12 weeks, performing 3 sets 8–12 repetitions 10 different exercises at 55–75% their hypothetical 1-repetition maximum. Exercise sessions were supervised and performed healthorientated fitness studio. Cognitive functions assessed by 4 neuropsychological tests. The MEMO memory test [6] was applied to verbal memory, Wilde intelligence subtest (WIT) [7] determine working d2 attention, consisting 2 tests,...
Cancer cachexia is a progressive wasting syndrome and the most prevalent characteristic of cancer in patients with advanced pancreatic adenocarcinoma. We hypothesize that genes expressed wasted skeletal muscle may determine initiation severity syndrome. studied gene expression biopsies from without utilizing Real-Imaging cDNA-AFLP-based transcript profiling for genome-wide analysis. Our approach yielded 183 cachexia-associated genes. Ontology analysis revealed changes number involved...
ABSTRACT PURPOSE To assess metabolism and microcirculation of healthy skeletal muscle by magnetic resonance (MR) ultrasound techniques to compare these data with histology, anthropometric blood parameters. METHODS Thirty‐four volunteers were selected such that their measured aerobic capacity (VO 2 max) per body weight ranged between 23 66 mL/minute/kg render a large variability capillarization as result different physical activity. We analyzed composition, parameters, fiber size in biopsies...
Brustkrebspatientinnen erleiden durch die Erkrankung und aggressive medizinische Therapie weit reichende physische psychische Einschränkungen. Vermehrt rücken auch kognitiven Fähigkeiten in den wissenschaftlichen Fokus, unter deren Einschränkung viele Betroffene während nach der Behandlung leiden, das so genannte "Chemobrain". Bisherige Studien mit Demenzkranken zeigten deutliche Verbesserungen Kognition bewegungstherapeutische Interventionen. Ziel dieser vorliegenden prospektiven...
Abstract Introduction: Up to 100% of all breast cancer patients are suffering from fatigue during chemotherapy [Mock 2001, Jacobsson 1998, Irvine 1994]. Causality as well the treatment this non-uniform symptom complex is yet unclear. Exercising studies show a positive effect endurance training on development [Dimeo 2003]. The study situation regarding feasibility and efficiency pure resistance with still unsatisfactory [De Backer 2009, Courneya 2007]. Methods: In prospective, controlled,...
Implementierung einer kontrastverstärkten Echtzeit low-MI Ultraschalltechnik (CEUS) zur Quantifizierung der Skelettmuskelperfusion, ihre Validierung durch Vergleich mit Venenverschlussplethysmografie (VOP) und Evaluierung während verschiedener Muskelbelastungen.
Einleitung: Krebspatienten erleiden körperliche wie auch psychische Einschränkungen nicht nur durch die Erkrankung und medizinische Therapien sondern Immobilität [Baumann 2005]. Die positiven Effekte von Ausdauertraining begleitend zur adjuvanten Behandlung sind erwiesen [Dimeo 2003]. Es liegen wenige Erfahrungen über Krafttrainingsprogramme mit vor [Courneya 2007]. In dieser Studie wurden Durchführbarkeit Auswirkungen eines Krafttrainings während der Chemotherapie Brustkrebspatientinnen untersucht.