A5007958342- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Advanced Nanomaterials in Catalysis
- Graphene and Nanomaterials Applications
- Nanoparticles: synthesis and applications
- Crystallography and molecular interactions
- Carbon and Quantum Dots Applications
- Nanofluid Flow and Heat Transfer
- Advanced biosensing and bioanalysis techniques
- Nanocluster Synthesis and Applications
- Nanoplatforms for cancer theranostics
- Electrochemical sensors and biosensors
- Advanced Photocatalysis Techniques
- Corrosion Behavior and Inhibition
- CRISPR and Genetic Engineering
- Minerals Flotation and Separation Techniques
- Catalysis and Oxidation Reactions
- Hearing, Cochlea, Tinnitus, Genetics
- Analytical Chemistry and Sensors
- Protease and Inhibitor Mechanisms
- Catalytic Processes in Materials Science
- Nutrition and Health in Aging
- Frailty in Older Adults
- Ear Surgery and Otitis Media
- Education, Safety, and Science Studies
Zhejiang Chinese Medical University
2024-2025
Soochow University
2016-2024
Anhui Agricultural University
2020-2024
CM Hospital
2024
Jazz Pharmaceuticals (United States)
2023
Guangxi University
2022
Shanghai University of Electric Power
2020-2021
University of Hong Kong
2021
Shandong University
2020-2021
State Key Laboratory of Medicinal Chemical Biology
2020-2021
Noble metal-based nanomaterials have shown promise as potential enzyme mimetics, but the facet effect and underlying molecular mechanisms are largely unknown. Herein, with a combined experimental theoretical approach, we unveil that palladium (Pd) nanocrystals exhibit facet-dependent oxidase peroxidase-like activities endow them excellent antibacterial properties via generation of reactive oxygen species. The efficiency Pd against Gram-positive bacteria is consistent extent their enzyme-like...
To develop nanomaterials as artificial enzymes, it is necessary to better understand how their physicochemical properties affect enzyme-like activities. Although prior research has demonstrated that exhibit tunable activities depending on size, structure, and composition, few studies have examined the effect of surface facets, which determine energy or reactivity. Here, we use electron spin-resonance spectroscopy report lower {111}-faceted Pd octahedrons greater intrinsic antioxidant...
Abstract Improving the antibacterial activity of H 2 O and reducing its usage are requirements for wound disinfection. Nanomaterials with intrinsic peroxidase‐like properties developed to enhance performance avoid toxicity seen high levels. Here, Pd–Pt core–frame nanodendrites consist a dense array platinum (Pt) branches on Pd core synthesized, subsequently converted Pt hollow by selective removal cores wet etching. The fabricated exert striking due maximized utilization efficiency atoms...
Graphene quantum dots (GQDs), zero-dimensional carbon materials displaying excellent luminescence properties, show great promise for medical applications such as imaging, drug delivery, biosensors, and novel therapeutics. A deeper understanding of how the properties GQDs interact with biological systems is essential these applications. Our work demonstrates that can efficiently scavenge a number free radicals thereby protect cells against oxidative damage. However, upon exposure to blue...
Before graphene derivatives can be exploited as next-generation antimicrobials, we must understand their behavior under environmental conditions. Here, demonstrate how exposure to simulated sunlight significantly enhances the antibacterial activity of oxide (GO) and reveal underlying mechanism. Our measurements reactive oxygen species (ROS) showed that only singlet (1O2) is generated by GO exposed sunlight, which contributes slightly oxidation antioxidant biomolecules. Unexpectedly, find...
Abstract Intravenous pharmacological dose of ascorbate has been proposed as a potential antitumor therapy; however, its therapeutic efficacy is limited due to the slow autoxidation. Here, we report that palladium (Pd) nanocrystals, which possess intrinsic oxidase-like activity, accelerate autoxidation ascorbate, leading enhancement efficacy. The activity Pd nanocrystals was facet-dependent, with concave nanostructure enclosed by high-index facets catalyzing more efficiently than planar...
Noble-metal-based nanomaterials made of less toxic metals have been utilized as potential antibacterial agents due to their distinctive oxidase-like activity. In this study, we fabricated core-shell structured Pd@Ir bimetallic with an ultrathin shell. nanostructures show morphology-dependent bactericidal activity, in which octahedra possessing higher activity exert stronger than that cubes. Furthermore, our results reveal the presence natural organic matter influences behaviors...
Frailty is a leading risk factor of falls, incapacitation, functional decline, and even death in aging populations globally. Clinical nurses play pivotal roles screening, prevention, intervention to reverse or slow the progression frailty. The present study aimed (1) understand extent influencing factors knowledge, attitudes, practices clinical for managing frailty, (2) elucidate relationships frailty management. This cross-sectional was conducted from March April 2024 on 524 tertiary...
Cuproptosis, an emerging cell death pathway, offers alternative approach for antimicrobial therapy, but it suffers from deficiencies and health risks. Here, we design hollow Cu-enriched Prussian blue-based nanostructures (Cu-HMPBs) find that the infected microenvironment facilitates release of Cu ions Cu-HMPBs, leading to overload in bacterial cells. Meanwhile, Fe cells are highly selectively chelated, triggering iron starvation. As a result, proteotoxic stress redox imbalance induced by...