J.-L. Dubois-Randé
A5077631360- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Acute Myocardial Infarction Research
- Cardiovascular Disease and Adiposity
- Cardiac Arrest and Resuscitation
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Nitric Oxide and Endothelin Effects
- Cardiac Ischemia and Reperfusion
- Pulmonary Hypertension Research and Treatments
- Heart Failure Treatment and Management
- Cerebrovascular and Carotid Artery Diseases
- Cardiac pacing and defibrillation studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Heart Rate Variability and Autonomic Control
- Cardiomyopathy and Myosin Studies
- Aortic Disease and Treatment Approaches
- Pain Management and Treatment
- Healthcare Systems and Practices
Assistance Publique – Hôpitaux de Paris
2013-2019
Hôpitaux Universitaires Henri-Mondor
1992-2019
Inserm
1994-2019
Université Paris-Est Créteil
2009-2019
Amyloidosis Foundation
2019
Centre Hospitalier Universitaire Henri-Mondor
1991-2019
Centre d'Immunologie et des Maladies Infectieuses
2017
Sorbonne Université
2017
Centre National de la Recherche Scientifique
2017
Université Paris Cité
2017
The MITOCARE study evaluated the efficacy and safety of TRO40303 for reduction reperfusion injury in patients undergoing revascularization ST-elevation myocardial infarction (STEMI). Patients presenting with STEMI within 6 h onset pain randomly received (n = 83) or placebo 80) via i.v. bolus injection prior to balloon inflation during primary percutaneous coronary intervention a double-blind manner. endpoint was infarct size expressed as area under curve (AUC) creatine kinase (CK) troponin I...
Aortic stenosis (AS) and transthyretin cardiac amyloidosis (TTR-CA) are both frequent in elderly. The combination of these two diseases has never been investigated.To describe patients with concomitant AS TTR-CA.Six cardiologic French centres identified retrospectively cases severe or moderate associated TTR-CA hospitalized during the last 6 years.Sixteen were included. Mean ± SD age was 79 years, 81% men. Sixty per cent NYHA III-IV, 31% had carpal tunnel syndrome, 56% atrial fibrillation....
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
BACKGROUND The role of vascular endothelium in the control epicardial coronary artery vasomotion during treadmill exercise remains unclear. Therefore, we examined consequences vivo balloon endothelial denudation on external diameter left circumflex conscious dogs. METHODS AND RESULTS Seven dogs instrumented for measurement arterial blood pressure, diameter, and flow were studied before up to 21 days after proximal artery. Endothelial was confirmed by abolition dilation induced acetylcholine...
Cardiac involvement is common in sickle cell disease (SCD). Studies are needed to establish haematological determinants of this and prognostic markers. The aim the study was identify factors associated with cardiac SCD their impact on prognosis. This longitudinal observational performed 1780 patients SS or S-β0-thalassemia referred our centre. Six hundred fifty-six met inclusion criteria (availability a blood-workup echocardiogram obtained <1 year apart, no heart valve surgery current...
Senescent pulmonary artery smooth muscle cells (PA-SMCs) may contribute to the pathogenesis of hypertension by producing secreted factors. The aim this study was explore role in extracellular matrix proteins released senescent PA-SMCs.Polymerase chain reaction array analysis human PA-SMCs undergoing replicative senescence revealed osteopontin upregulation, which mediated stimulatory effect PA-SMC media and on growth migration. Osteopontin upregulated lungs from patients with chronic...
We investigated whether rapid cooling instituted by total liquid ventilation (TLV) improves cardiac and mitochondrial function in rabbits submitted to ischaemia-reperfusion. Rabbits were chronically instrumented with a coronary artery occluder myocardial ultrasonic crystals for assessment of segment length-shortening. Two weeks later they re-anaesthetized underwent either normothermic 30-min occlusion (CAO) (Control group, n = 7) or comparable CAO initiated 10-min hypothermic TLV maintained...
Treatment of acute ST-elevation myocardial infarction (STEMI) by reperfusion using percutaneous coronary intervention (PCI) or thrombolysis has provided clinical benefits; however, it also induces considerable cell death. This process is called injury. The continuing high rates mortality and heart failure after (AMI) emphasize the need for improved strategies to limit injury improve outcomes. objective this study assess safety efficacy TRO40303 in limiting patients treated STEMI. targets...
The activation of the calpain system is involved in repair process following myocardial infarction (MI). However, impact inhibition by calpastatin, its natural inhibitor, on scar healing and left ventricular (LV) remodeling elusive. Male mice ubiquitously overexpressing calpastatin (TG) wild-type (WT) controls were subjected to an anterior coronary artery ligation. Mortality at 6 wk was higher TG (24% WT vs. 44% TG, P < 0.05) driven a significantly incidence cardiac rupture during first week...
Abstract Aims Same‐day discharge (SDD) after percutaneous coronary intervention (PCI) was safe and cost‐effective in randomized observational studies but faces limited acceptance due to concerns about early adverse events. Our aim evaluate outcomes SDD PCI a high‐volume urban center over 10 years. Methods results From 2007 2016, 1,635 unselected patients had at our ambulatory cardiac care unit, mainly for stable ischemic heart disease (SIHD). Among them, 1,073 (65.6%), most of whom underwent...
Out-of-hospital cardiac arrest (OHCA) is a common cause of death. Early circulatory failure the most reason for death within first 48 h. This study in intensive care unit (ICU) patients with OHCA was designed to identify and characterize clusters based on clinical features determine frequency from refractory postresuscitation shock (RPRS) each cluster. We retrospectively identified adults admitted alive ICUs after 2011-2018 recorded prospective registry Paris region (France). patient by...
Organ shortage is a major public health issue, and patients who die after out-of-hospital cardiac arrest (OHCA) could be valuable source of organs. Here, our objective was to identify factors associated with organ donation brain death complicating OHCA, in unselected entered into comprehensive real-life registry covering well-defined geographic area.We prospectively analyzed consecutive adults OHCA were successfully resuscitated, but died intensive care units the Paris region 2011-2018. The...
Cromakalim and pinacidil, two potassium channel openers, dilate both large small coronary arteries in conscious dogs. Because flow-mediated dilation of is endothelium-dependent, the consequences vivo endothelium removal (balloon denudation) on response epicardial to cromakalim (10 micrograms/kg) pinacidil (30 were investigated six dogs chronically instrumented for measurement arterial pressure, left circumflex artery diameter blood flow. Endothelium abolished induced by acetylcholine...