A5101892079- Multiple Sclerosis Research Studies
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Vaccine Coverage and Hesitancy
- Viral-associated cancers and disorders
- Herpesvirus Infections and Treatments
- Eosinophilic Disorders and Syndromes
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Polyomavirus and related diseases
- Neurological diseases and metabolism
- Health and Medical Studies
- Colorectal Cancer Treatments and Studies
- Viral Infections and Immunology Research
- Intimate Partner and Family Violence
- Cytomegalovirus and herpesvirus research
- Influenza Virus Research Studies
- Cell Image Analysis Techniques
- SARS-CoV-2 and COVID-19 Research
- Venous Thromboembolism Diagnosis and Management
- Immune Response and Inflammation
- Systemic Lupus Erythematosus Research
- Cervical Cancer and HPV Research
- Ethics and Legal Issues in Pediatric Healthcare
- Prion Diseases and Protein Misfolding
Karolinska Institutet
2022-2025
Case Western Reserve University
2023-2024
University of Birmingham
2019-2024
Western University of Health Sciences
2023
Sanofi (Germany)
2018
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system, for which and Epstein-Barr virus (EBV) infection a likely prerequisite. Due to homology between nuclear antigen 1 (EBNA1) alpha-crystallin B (CRYAB), we examined antibody reactivity EBNA1 CRYAB peptide libraries in 713 persons with MS (pwMS) 722 matched controls (Con). Antibody response amino acids 7 16 was associated (OR = 2.0), combination high responses positivity markedly increased risk 9.0). Blocking...
Multiple sclerosis (MS) is an autoimmune demyelinating disorder of the central nervous system (CNS), which linked to Epstein–Barr virus (EBV) infection, preceding disease. The molecular mechanisms underlying this connection are only partially understood. We previously described mimicry between EBV transcription factor nuclear antigen 1 (EBNA1) and three human CNS proteins: anoctamin-2 (ANO2), alpha-B crystallin (CRYAB), glial cellular adhesion molecule (GlialCAM). Here, we investigated...
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS), in which pathological T cells, likely autoimmune, play a key role. Despite its importance, autoantigen repertoire remains largely uncharacterized. Using novel vitro antigen delivery method combined with Human Protein Atlas library, we screened for cell autoreactivity against 63 CNS-expressed proteins. We identified four previously unreported autoantigens MS: fatty acid-binding protein 7, prokineticin-2,...
Epstein-Barr virus (EBV) is an important human pathogen which causes lifelong infection of > 90% people globally and linked to infectious mononucleosis (arising from in the later teenage years) several types cancer. Vaccines against EBV are development. In order determine most cost-effective public health strategy for vaccine deployment, setting-specific data on age at acquisition risk factors early required. Such also inform mathematical models transmission that can required target product...
Background Epstein-Barr virus (EBV) is a likely prerequisite for multiple sclerosis (MS) but the underlying mechanisms are unknown. We investigated antibody and T cell responses to EBV in persons with MS (pwMS), healthy EBV-seropositive controls (HC) post-infectious mononucleosis (POST-IM) individuals up 6 months after disease resolution. The ability of EBV-specific target antigens from central nervous system (CNS) was also investigated. Methods Untreated relapsing-remitting MS, POST-IM HC...
Multiple sclerosis (MS) is a prototypical autoimmune disease of the central nervous system (CNS). In addition to CD4 + T cells, memory B cells are now recognized as critical cell type in disease. This underlined by fact that best-characterized environmental risk factor for MS Epstein-Barr virus (EBV), which can infect and persist throughout life. Several studies have identified changes anti-EBV immunity patients with MS. Examples include elevated titers nuclear antigen 1 (EBNA1) antibodies,...
Abstract Background Human cytomegalovirus (CMV) is a common herpesvirus which estimated to infect 83% of the global population. Whilst many infections are asymptomatic, it an important cause morbidity and mortality, particularly for immunocompromised people infants who congenitally infected. A vaccine against CMV has been stated as public health priority, but there gaps in our understanding epidemiology. To guide potential future vaccination strategies, aim was examine risk factors...
Hybrid immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develops from a combination of natural infection and vaccine-generated immunity. Multiple sclerosis (MS) disease-modifying therapies (DMTs) have the potential impact humoral cellular induced by SARS-CoV-2 vaccination infection. The aims were compare antibody T-cell responses after mRNA in persons with MS (pwMS) treated different DMTs assess differences between naïvely vaccinated pwMS hybrid following previous...
To explore spatial differences and specificity of brain 3R/4R tau seeding its relationship with histopathological burden using real time quaking induced conversion (RT-QuIC) digital histological immunohistochemistry in patients tauopathies.
Abstract Background IBD had a relative risk of 2.2 for VTE compared to the normal population. In May 2020, an international consensus created statement on prevention in patients. 28days extended thromboprophylaxis was recommended after discharge only high We aimed identify high-risk patients post-IBD-related bowel resection. Methods Retrospective review 131 over 5 years surgical admissions IBD-related resection at DGH. Examined factors included patients’ demographics, VTE, disease history,...
Abstract Introduction IBD patients are highly susceptible to PO morbidities. This study aimed look at the predictors of AL and associated morbidities during hospital stays increase awareness these patients. Methods A 5-year retrospective in DGH. All variables were evaluated:patient-dependent (Age, Gender, BMI, ethnic group, comorbidities),disease-dependent (type IBD, disease location, duration), surgery-dependent (duration, CEPOD type, approach, type resection),Postoperative(CRP level, VTE,...
Abstract Select prion diseases are characterized by widespread cerebral plaque-like deposits of amyloid fibrils enriched in heparan sulfate (HS), a major extracellular matrix component. HS facilitates fibril formation vitro , yet how impacts fibrillar plaque growth within the brain is unclear. Here we found that prion-bound chains highly sulfated, and sulfation essential for accelerating conversion . Using conditional knockout mice to deplete enzyme, Ndst1 (N-deacetylase,...
We discovered that the immune response to a common virus called Epstein-Barr may be linked multiple sclerosis by cross-reacting with protein in body alpha-crystallin B . People who reacted this were more likely develop disease, and finding is step forward our understanding of how cause disease some people.