A5046548696- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrospinal fluid and hydrocephalus
- Ferroptosis and cancer prognosis
- Viral Infections and Vectors
- ATP Synthase and ATPases Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Glioma Diagnosis and Treatment
- Viral Infections and Outbreaks Research
- RNA modifications and cancer
- Fire effects on ecosystems
- Cancer-related gene regulation
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Pituitary Gland Disorders and Treatments
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Intracranial Aneurysms: Treatment and Complications
- Mitochondrial Function and Pathology
- Ion Transport and Channel Regulation
- Autophagy in Disease and Therapy
- Sesquiterpenes and Asteraceae Studies
- Marine Sponges and Natural Products
- Barrier Structure and Function Studies
- Advanced Nanomaterials in Catalysis
- Spinal Dysraphism and Malformations
First Affiliated Hospital of Soochow University
2022-2025
Soochow University
2022-2025
Zhongshan Hospital of Xiamen University
2024
Fudan University
2024
Zhongshan Hospital
2024
Sun Yat-sen University
2024
Xiamen Blood Center
2024
Second Hospital of Anhui Medical University
2024
Anhui Medical University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Intracerebral hemorrhage (ICH) is a subtype of stroke marked by elevated mortality and disability rates. Recently, mounting evidence suggests significant role ferroptosis in the pathogenesis ICH. Through combination bioinformatics analysis basic experiments, our goal to identify primary cell types key molecules implicated post-ICH. This aims propel advancement research, offering potential therapeutic targets for ICH treatment. Our study reveals pronounced microglia identifies target gene,...
The infiltration of blood components into the brain parenchyma through lymphoid system is an important cause subarachnoid hemorrhage injury. AQP4, a water channel protein located at astrocyte foot, has been reported to regulate blood–brain barrier integrity, and its polarization disrupted after SAH. Neuronal ferroptosis involved in hemorrhage- (SAH-) induced injury, but inducing factors are not completely clear. Transferrin one ferroptosis. This study aimed researching role mechanism AQP4...
Cerebral ischemia–reperfusion (I/R) injury in ischemic penumbra is accountable for poor outcome of stroke patients receiving recanalization therapy. Compelling evidence previously demonstrated a dual role autophagy stroke. This study aimed to understand the traits and potential mechanism that switches autophagy. We found induction by rapamycin lithium carbonate performed before ischemia reduced neurologic deficits infarction, while after reperfusion had opposite effect male murine middle...
Background Sex differences affect the occurrence, progression and regression of subarachnoid haemorrhage (SAH). Oestrogen plays a protective role in alleviating vasospasm neuronal apoptosis induced by SAH. However, whether oestrogen affects blood‒brain barrier (BBB) integrity has not been fully studied. found to regulate sonic hedgehog (SHH) signalling pathway through receptor gastric cancer adrenal glands, SHH an important maintaining BBB upregulating expression tight junction proteins. In...
Blood-brain barrier (BBB) damage significantly affects the prognosis of ischemic stroke patients. This project employed multi-omics analysis to identify key factors regulating BBB disruption during cerebral ischemia-reperfusion. An integrated three transcriptome sequencing datasets from mouse middle artery occlusion/reperfusion (MCAO/R) models identified eight downregulated genes in endothelial cells. Additionally, (cortex) and non-BBB (lung) endothelium E13.5 mice revealed 2,102 upregulated...
<title>Abstract</title> Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging global infectious disease a high mortality rate. Clinicians lack convenient tool for early identification of critically ill SFTS patients. The aim this study was to construct simple and accurate nomogarm predict the prognosis Methods We retrospectively analyzed clinical data 372 patients collected between May 2015 June 2023, which were divided 7:3 into training set internal validation set....
Previous drug repositioning studies have suggested that parthenolide may be a differentiation-inducing agent for glioma cells. This study aimed to experimentally verify the neuronal effects and proliferative impact of on human cells explore its potential mechanisms.
Neuron conversion leads to proliferation inhibition of glioma cells and may be an effective strategy combat prevent recurrence. In this study, drug repositioning based on Connectivity Map (CMap) was conducted discover drugs that could induce the differentiation into neuron-like cells, complemented by in vitro experimental validation. Downregulated neuronal genes were identified Human Protein Atlas database GeneCards database, enrichment analysis Gene Expression Profiling Interactive Analysis...