A5030508122- Force Microscopy Techniques and Applications
- Lipid Membrane Structure and Behavior
- Advanced biosensing and bioanalysis techniques
- Mechanical and Optical Resonators
- Carbon Nanotubes in Composites
- Molecular Junctions and Nanostructures
- Advanced Sensor and Energy Harvesting Materials
- Microfluidic and Bio-sensing Technologies
- Photoreceptor and optogenetics research
- Nanopore and Nanochannel Transport Studies
- Cellular Mechanics and Interactions
- RNA Interference and Gene Delivery
- Advanced Materials and Mechanics
- Conducting polymers and applications
- Spectroscopy and Quantum Chemical Studies
- Polysaccharides and Plant Cell Walls
- Neuroscience and Neural Engineering
- Plant Reproductive Biology
- Dielectric materials and actuators
- Alzheimer's disease research and treatments
- Atomic and Subatomic Physics Research
- Ion channel regulation and function
- Advanced Thermoelectric Materials and Devices
- Plasmonic and Surface Plasmon Research
- Magnetic and Electromagnetic Effects
University of Oxford
2012-2024
University of Greenwich
2024
Google (United States)
2020
Science Oxford
2015
University of Surrey
2008
National Physical Laboratory
2008
Aarhus University
2003-2005
Osaka University
1998-2002
Osaka Research Institute of Industrial Science and Technology
2001
The physical properties of lipid bilayers comprising the cell membrane occupy current spotlight biology. Their traditional representation as a passive 2D fluid has gradually been abandoned in favor more complex picture: an anisotropic time-dependent viscoelastic biphasic material, capable transmitting or attenuating mechanical forces that regulate biological processes. In establishing new models, quantitative experiments are necessary when attempting to develop suitable techniques for...
The 1980s mark the starting point of nanotechnology: capacity to synthesise, manipulate and visualise matter at nanometre scale. New powers reach nanoscale brought us unprecedented possibility directly target scale biomolecular interactions, motivation create smart nanostructures that could circumvent hurdles hindering success traditional pharmacological approaches. Forty years on, progressive integration bio- nanotechnologies is produce a transformation way we detect, treat monitor diseases...
The last five decades of molecular and systems biology research have provided unprecedented insights into the genetic basis many cellular processes. Despite these insights, however, it is arguable that there still only limited predictive understanding cell behaviours. In particular, heterogeneity in single-cell behaviour initiation different metabolic, transcriptional or mechanical responses to environmental stimuli remain largely unexplained. To go beyond status quo , behaviours emerging...
Silver nanoparticles are extensively used due to their chemical and physical properties promising applications in areas such as medicine electronics. Controlled synthesis of silver remains a major challenge the difficulty producing long-term stable particles same size shape aqueous solution. To address this problem, we examine three strategies stabilise solutions 15 nm citrate-reduced using organic polymeric capping, bimetallic core-shell alloying. Our results show that these drastically...
The HIV-1 genome consists of two identical RNA strands that are linked together through non-covalent interactions. A major determinant for efficient dimerization the is interaction between palindromic sequences in initiation site. Here we use an interplay bioinformatics, biochemistry, and atomic force microscopy to describe another conserved palindrome trans-activation response element (TAR) functions as a strong site when transiently exposed viral nucleocapsid protein. In conjunction with...
Intercalation of drug molecules into synthetic DNA nanostructures formed through self-assembled origami has been postulated as a valuable future method for targeted delivery. This is due to the excellent biocompatibility nanostructures, and high potential flexible programmability including facile release or near target cells. Such favourable properties may enable initial loading efficient predictable number per nanostructure carrier, important delivery safe effective doses minimise...
Abstract The Arabidopsis sensitive-to-freezing8 (sfr8) mutant exhibits reduced cell wall (CW) fucose levels and compromised freezing tolerance. To examine whether CW fucosylation also affects the response to desiccation, we tested effect of leaf excision in sfr8 allelic mur1-1. Leaf water loss was strikingly higher than wild type these, but not other, mutants. We hypothesized that guard (GC) walls might limit stomatal closure through altering mechanical properties. Multifrequency atomic...
Polymeric materials are widely used in industries ranging from automotive to biomedical. Their mechanical properties play a crucial role their application and function arise the nanoscale structures interactions of constitutive polymer molecules. behave viscoelastically, i.e., responses depend on time scale measurements; quantifying these time-dependent rheological at is relevant develop, for example, accurate models simulations those materials, which needed advanced industrial applications....
Investigating nonlinear fluid dynamics remains a challenge across physics from nanofluidics and biophysics to astrophysics. Here we introduce quantum/classical theoretical approach that takes into account both quantum correlations classical behaviour within 2D is confined in 3 μm side square. We employ modified Gross-Pitaevskii equation, encompassing many-body interactions confinement. This system reveals complex characterised by dissipative solitons; significant outcome an asymptotic...
Doping of carbon nanotubes with nitrogen during growth strongly modifies their electronic structure through n-type doping. This provides the possibility producing high conductances, independent tube chirality. To date, electrical measurements on individual nitrogen-doped multiwalled (CNx MWNTs) have reported surprisingly low conductances (∼0.01G0). Here authors present conductance (1.0±0.3G0) at bias for CNx MWNTs. Conductance increases linearly voltage a rate 0.7±0.2G0∕V until threshold...
AFM imaging and nanoindentation complemented by FTIR light scattering revealed the effect of intramembrane fullerene C<sub>60</sub> on fluid gel phase lipid bilayers.
Future lipid membrane-associated DNA nanostructures are expected to find applications ranging from synthetic biology nanomedicine. Here we have designed and synthesized tiles modified them with amphiphilic covalent moieties. dod-DEG groups, which consist of a hydrophilic diethylene glycol (DEG) hydrophobic dodecyl group, introduced at the phosphate backbone create strands subsequently into one face tiles. In this way tile becomes able stably bind membranes by insertion groups inside bilayer...
Poly(3,4-ethylenedioxythiophene) (PEDOT), a well-characterized conducting polymer, has been applied for coating metal neural electrodes to improve their stimulating or recording performance. The coated possess advantages in better neuron attachment, lower impedance, and larger capacitance compared the bare substrate due biocompatibility porous surface of polymer. However, PEDOT-coated have frequently reported issues associated with mechanical instability, such as cracking delamination....
Magnetic AC mode (MACmode) atomic force microscopy (AFM) was used to study murine (mouse) MC3T3-E1 preosteoblastic cells attached biocompatible tantalum substrates.Cell volumes of derived from AFM images were compared detached in suspension measured by the Coulter sizing technique.An increase ~ 50 % cell volume observed when planar substrates and developed a flattened structure including lamellipodia.We address thoroughly issues general determination absolute volumes, compare our magnetic...
Relevant parameters for non-covalent protein functionalization of carbon nanotubes are explored. Multiwalled carboxylated and functionalized with metalloproteins. Using atomic force microscopy (AFM) we quantitatively determine that coverage nitrogen-doped multiwalled is superior compared to un-doped nanotubes, due enhanced carboxylation. Conformational analysis using a combination AFM, antibody binding assays, circular dichroism UV–visible spectroscopy demonstrates the metalloproteins retain...