A5074492756- Bacterial biofilms and quorum sensing
- Antibiotic Resistance in Bacteria
- Diphtheria, Corynebacterium, and Tetanus
- Bacterial Genetics and Biotechnology
- Vibrio bacteria research studies
- Bacteriophages and microbial interactions
- Antimicrobial Peptides and Activities
- MicroRNA in disease regulation
- Mycobacterium research and diagnosis
- Bacterial Identification and Susceptibility Testing
- Genomics and Phylogenetic Studies
- Veterinary medicine and infectious diseases
- Microbial Community Ecology and Physiology
- RNA and protein synthesis mechanisms
- Evolutionary Game Theory and Cooperation
- Enterobacteriaceae and Cronobacter Research
- Circular RNAs in diseases
- Antimicrobial Resistance in Staphylococcus
- Cancer Immunotherapy and Biomarkers
- Clostridium difficile and Clostridium perfringens research
- PI3K/AKT/mTOR signaling in cancer
- Toxin Mechanisms and Immunotoxins
- Lung Cancer Treatments and Mutations
- Plant-based Medicinal Research
- Cancer-related molecular mechanisms research
Chengdu University
2018-2025
First Affiliated Hospital of Xinxiang Medical University
2018-2025
Xinxiang Medical University
2019-2024
Sichuan University
2011-2021
Dalhousie University
2021
State Key Laboratory of Biotherapy
2018
Nanfang Hospital
2014-2018
Southern Medical University
2017-2018
University of North Dakota
2013-2015
Sinopec (China)
2013
Abstract P seud omon as aeruginosa is a common opportunistic pathogen with growing resistance and presents heightened treatment challenges. Quorum sensing (QS) cell-to-cell communication system that contributes to the production of variety virulence factors also related biofilm formation P. . Compared traditional antibiotics which kill bacteria directly, anti-virulence strategy by targeting QS promising for combating pseudomonal infections. In this study, inhibition potential compounds...
Abstract Molecular docking is a structure-based and computer-aided drug design approach that plays pivotal role in discovery pharmaceutical research. AutoDock the most widely used molecular tool for study of protein–ligand interactions virtual screening. Although many tools have been developed to streamline automate pipeline, some them still use outdated graphical user interfaces not updated long time. Meanwhile, lack cross-platform compatibility evaluation metrics screening lead compound...
Trueperella pyogenes is a commensal and opportunistic pathogen that normally causes mastitis, liver abscesses pneumonia of economically important livestock. To develop efficacious potent vaccine against T. pyogenes, chimeric gene DNA vaccines were constructed encapsulated in chitosan nanoparticles (pPCFN-CpG-CS-NPs).The pPCFN-CpG-CS-NPs consists the plo, cbpA, fimA, nanH CpG ODN1826. It was produced with good morphology, high stability, mean diameter 93.58 nm, zeta potential + 5.27 mV....
Chronic infection with the bacterial pathogen Pseudomonas aeruginosa often leads to coexistence of heterogeneous populations carrying diverse mutations. In particular, loss-of-function mutations affecting quorum-sensing regulator LasR are found in bacteria isolated from patients lung chronic and cystic fibrosis. Here, we study evolutionary dynamics polymorphic P. using isolates longitudinally collected obstructive pulmonary disease (COPD). We find that deficient production different sharable...
Arcanobacterium pyogenes is commonly isolated from ruminant animals as an opportunistic pathogen that co-infects with other bacteria, normally causing surface or internal abscesses. Twenty-eight strains of A. forest musk deer suppurative samples were identified by their 16S rRNA gene sequences, and confirmed amplification the pyolysin-encoding (plo) in all isolates. The MICs 14 used antibiotics determined agar dilution method. Class 1 2 intI genes amplified to determine whether integrons...
Microsatellites are highly polymorphic repeat sequences ubiquitously interspersed throughout almost all genomes which widely used as powerful molecular markers in diverse fields. Microsatellite expansions play pivotal roles gene expression regulation and implicated various neurological diseases cancers. Although much effort has been devoted to developing efficient tools for microsatellite identification, there is still a lack of tool large-scale analysis. We present Krait2, user-friendly...
Abstract Aim Pseudomonas aeruginosa employs the quorum sensing (QS) system, a sophisticated cell-to-cell communication mechanism, to modulate synthesis and secretion of range virulence factors, which contribute establishment acute or chronic infections in hosts. This study seeks attenuate P. by inhibiting QS thereby reducing its pathogenicity as promising alternative traditional antibiotics. Methods results Two compounds with an amino-substituted diphenyl fumaramide core,...
As antibiotic resistance escalates into a global health crisis, novel therapeutic approaches against infectious diseases are in urgent need. Pseudomonas aeruginosa, an adaptable opportunistic pathogen, poses substantial challenges treating range of infections. The quorum-sensing (QS) system plays pivotal role orchestrating the production large set virulence factors cell density-dependent manner, and anti-virulence strategy targeting QS may show huge potential. Here, we present comprehensive...
ABSTRACT Bacteria can naturally secrete outer membrane vesicles (OMVs) as pathogenic factors, while these may also serve immunologic regulators if appropriately prepared. However, it is largely unknown whether Pseudomonas aeruginosa OMVs activate inflammatory responses and immunization with provide immune protection against subsequent infection. We purified identified OMVs, which were then used to infect lung epithelial cells in vitro well C57BL/6J mice investigate the response underlying...
Microbial communities are susceptible to the public goods dilemma, whereby individuals can gain an advantage within a group by utilizing, but not sharing cost of producing, goods. In bacteria, development quorum sensing (QS) establish cooperation system in population coordinating production costly and sharable extracellular products (public goods). Cooperators with intact QS robust ability producing vulnerable being undermined QS-deficient defectors that escape from benefit others. Although...
<b><i>Background:</i></b> Hyperfibrinogenaemia and thrombocytosis, which usually occur in cancer patients, have been shown to contribute cell growth, progression, metastasis. The aims of the present study were assess prognostic significance pretreatment plasma fibrinogen platelet levels early-stage cervical patients. <b><i>Methods:</i></b> was a retrospective analysis 220 patients with stage I-IIA disease. investigated along clinicopathological...
Although osimertinib, an EGFR tyrosine kinase inhibitor, has become the standard therapy for treating non-small cell lung cancer (NSCLC) patients with EGFR-activating mutation, upregulation of MCL-1 induces acquired resistance to osimertinib. Bufalin, a natural digoxin-like ingredient isolated from traditional Chinese medicine Chan Su, been shown downregulate in NSCLC cells. However, whether bufalin reverses this osimertinib cells remains unclear. In study, reduced viability and promoted...
Thermal environments are an important reservoir of thermophiles with significant ecological and biotechnological potentials. However, thermophilic isolates remain largely unrecovered from their habitats rarely systematically identified. In this study, we characterized using polyphasic approaches a strain, PKUAC-SCTAE412 (E412 hereafter), recovered Lotus Lake hot spring based in Ganzi prefecture, China. The results 16S rRNA/16S-23S ITS phylogenies, secondary structure, morphology comparison...
Pseudomonas aeruginosa relies on its complex cellular regulatory network to produce a series of virulence factors and cause various acute chronic infections in wide range hosts. Compared with traditional antibiotics which frequently accompany widespread antibiotic resistance, crippling the system bacteria is expected be promising anti-infective strategy. In this study, Dimetridazole Ribavirin, had poor antibacterial activities P. reference isolate PAO1 nutrient medium but significantly...
Klebsiella pneumoniae is an important gram-negative bacterium that causes severe respiratory and healthcare-associated infections. Although antibiotic therapy applied to treat infections caused by K. pneumoniae, drug-resistant isolates pose a huge challenge clinical practices owing adverse reactions the mismanagement of antibiotics. Several studies have attempted develop vaccines against but there are no licensed available for control infection. In current study, we constructed novel DNA...