A5059624466- Cancer-related molecular mechanisms research
- PI3K/AKT/mTOR signaling in cancer
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Colorectal Cancer Treatments and Studies
- Quinazolinone synthesis and applications
- Cancer Mechanisms and Therapy
- Hematological disorders and diagnostics
- Cell death mechanisms and regulation
- interferon and immune responses
- Immune cells in cancer
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Cancer Immunotherapy and Biomarkers
- Fibromyalgia and Chronic Fatigue Syndrome Research
- ATP Synthase and ATPases Research
- Autophagy in Disease and Therapy
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Cytokine Signaling Pathways and Interactions
- Medicinal Plant Pharmacodynamics Research
- Epigenetics and DNA Methylation
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2005-2025
Shanghai University of Traditional Chinese Medicine
2008-2025
Shanghai University
2009-2015
Traditional Chinese medicine (TCM) is an important part of the treatment primary liver cancer (PLC) in China; however, current instructions for integrative use traditional and Western PLC are mostly based on expert opinion. There no evidence-based guideline clinical practice this field. Therefore, Shanghai Association Integrative Medicine has established a multidisciplinary working group to develop guideline, which focuses most questions about TCM during treatment. This was developed...
Cinobufocini injection is a preparation containing water-soluble components of the toad skin. The aim present study was to investigate apoptosis human lung adenocarcinoma cell line A 549 induced by cinobufocini. or HLF-1(human fibroblast) cells were treated with cinobufocini at different concentrations for 24 and 48 h, respectively. proliferation detected 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay. Morphology carried out scanning electronic microscopy (SEM)...
Although osimertinib, an EGFR tyrosine kinase inhibitor, has become the standard therapy for treating non-small cell lung cancer (NSCLC) patients with EGFR-activating mutation, upregulation of MCL-1 induces acquired resistance to osimertinib. Bufalin, a natural digoxin-like ingredient isolated from traditional Chinese medicine Chan Su, been shown downregulate in NSCLC cells. However, whether bufalin reverses this osimertinib cells remains unclear. In study, reduced viability and promoted...
Abstract Stimulator of interferon genes (STING) controlled innate immune pathway is essential for host defense against pathogenic infection and effective anti-tumor adaptive immunity initiation. Although macrophages transformed across diverse phenotypes play crucial roles in response, events determining this transformation the host-intrinsic role STING process remain controversial. Here we report how signaling acts as a key switch to dominate gene expression patterns macrophage promoting...
Our previous study revealed that Shuanghuang Shengbai granule could cure the myelosuppression induced by cyclophosphamide (CTX) in lung cancer. However, its hematopoietic effects and molecular mechanisms remain not fully understood. Therefore, this was intended to investigate underlying of Astragaloside IV (AS) saponins rhizoma polygonati (SRP), two main bioactive ingredients granule, on CTX-induced myelosuppression. CTX inhibited proliferation promoted apoptosis bone marrow stem cells...
The expression of integrin‑linked kinase (ILK) has been reported to be involved in the regulation integrin‑mediated processes, including cancer cell proliferation, migration and invasion. Previous studies have demonstrated that inhibition ILK may an underlying approach for treating cancer. However, whether knock down affects growth apoptosis lung cells remains elucidated. Importantly, downregulation increases sensitivity cisplatin amplifies also In present study, was mediated by...
Metabolic reprogramming is a core hallmark of cancer and key for tumorigenesis tumor progression. Investigation metabolic perturbation by anti-cancer compounds would allow thorough understanding the underlying mechanisms these agents identification new targets. Here, we demonstrated that administration oleanolic acid (OA) rapidly altered metabolism, particularly suppressing purine salvage pathway (PSP). PSP restoration significantly opposed OA-induced DNA replication cell proliferation...
New therapeutic approaches are required to improve the outcomes of lung cancer (LC), a leading cause cancer-related deaths worldwide. Chinese herbal medicine formulae widely used in China provide unique opportunity for improving LC treatment, and Shuang-Huang-Sheng-Bai (SHSB) formula is typical example. However, underlying mechanisms action remains unclear.This study aimed confirm efficacy SHSB against adenocarcinoma (LUAD), which major histological type LC, unveil downstream targets this...
While the significance of immunogenic cell death (ICD) in oncology is acknowledged, its specific impact on colorectal carcinoma remains underexplored. In this study, we delved into role ICD carcinoma, a topic not yet comprehensively explored. A novel quantification system was developed to forecast patient outcomes and effectiveness immunotherapy. Utilizing single-cell sequencing, constructed an score within tumor immune microenvironment (TIME) examined related genes (ICDRGs). Using data from...
The aim of the study wasto explore target and potential mechanism Scutellariae Radix Astragaloside in treatment lung cancer infection by network pharmacology. information baicalein flavonin was mined from CTD database Swiss database. Genecards database, DRUGBANK OMIM were used to search for related genes. protein map (PPI) drawn using STRING analysis Cytoscape3.7.1 software. With help Perl language, Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment gene function (GO) carried out...