A5080415757- Muscle Physiology and Disorders
- Nutrition and Health in Aging
- Mesenchymal stem cell research
- Diet and metabolism studies
- Extracellular vesicles in disease
- Exercise and Physiological Responses
- Muscle metabolism and nutrition
- Tissue Engineering and Regenerative Medicine
- Myofascial pain diagnosis and treatment
- Cardiovascular Health and Disease Prevention
- Adipose Tissue and Metabolism
- Dietary Effects on Health
- Cardiovascular Disease and Adiposity
- Colorectal Cancer Screening and Detection
- Mitochondrial Function and Pathology
- Sleep and Wakefulness Research
- Xenotransplantation and immune response
- Radiomics and Machine Learning in Medical Imaging
- Tea Polyphenols and Effects
- Neurogenesis and neuroplasticity mechanisms
- Child Nutrition and Feeding Issues
- Child Nutrition and Water Access
- Muscle activation and electromyography studies
- Infant Nutrition and Health
- Pharmacological Effects and Assays
University of Illinois Urbana-Champaign
2016-2023
Abbott Nutrition (United States)
2020-2022
Abbott (United States)
2020-2022
Abbott (Canada)
2020
University of Illinois System
2020
Urbana University
2019
Background: Five of the most abundant human milk oligosaccharides (HMOs) in are 2'-fucosyllactose (2'-FL), 3-fucosyllactose (3-FL), lacto-N-tetraose (LNT), 3'-sialyllactose (3'-SL) and 6'-sialyllactose (6'-SL). Methods: A randomized, double-blind, controlled parallel feeding trial evaluated growth healthy term infants fed a control milk-based formula (CF; n = 129), experimental (EF; 130) containing five HMOs (5.75 g/L; 2'-FL, 3-FL, LNT, 3'-SL 6'-SL) or (HM; 104). Results: No significant...
Abstract Cholesterol has been implicated in the clinical progression of breast cancer, a disease that continues to be most commonly diagnosed cancer women. Previous work identified cholesterol metabolite 27-hydroxycholesterol (27HC) as major mediator effects on tumor growth and progression. 27HC can act an estrogen receptor (ER) modulator promote ERα+ tumors, liver X (LXR) ligand myeloid immune cells establish immune-suppressive program. In fact, metastatic properties require presence with...
Stem cell transplantation has been a promising treatment for peripheral arterial diseases in the past decade. cells act as living bioreactors of paracrine factors that orchestrate tissue regeneration. Prestimulated adipose-derived stem (ADSCs) have proposed potential candidates but met with challenges activating their secretory activities clinical use. Here, we propose tethering ADSC surface nanoparticles releasing tumor necrosis factor α (TNFα), named nanostimulator, would stimulate...
Abstract Introduction Stunting is a devastating consequence of poor nutrition from before birth to early childhood. While the prevalence stunting decreasing over past 30 years, approximately 144 million children still suffer globally and 5 in Latin America (LATAM). Method The purpose this review provide an overview globally, with focus on LATAM. can impact child development, lead greater susceptibility infections, increase functional impairments, mortality risks. Furthermore, economic...
Conditions of extended bed rest and limb immobilization can initiate rapid significant loss skeletal muscle mass function. Physical rehabilitation is standard practice following a period disuse, yet mobility may be severely compromised, recovery commonly delayed or incomplete in special populations. Thus, novel approach toward highly desired. Pericytes [neuron-glial antigen 2 (NG2)+CD31-CD45- (Lineage- [Lin-]) CD146+Lin-] demonstrate capacity to facilitate repair, the ability enhance...
Extended periods of bed rest and limb immobilization are required for healing post-injury or disease, yet disuse can result in significant muscle atrophy decreased quality life older adults. Physical rehabilitation is commonly prescribed to recover these deficits, accumulation reactive oxygen species sustained rates protein degradation persist during the period that significantly delay prevent recovery. Pericytes, considered primary mesenchymal vascular stromal cell skeletal muscle, secrete...
Unaccustomed resistance exercise can initiate skeletal muscle remodeling and adaptive mechanisms that confer protection from damage enhanced strength with subsequent stimulation. The myofiber may provide the primary origin for adaptation, yet multiple mononuclear cell types within surrounding connective tissue also contribute. purpose of this study was to evaluate acute response muscle-resident interstitial cells contraction initiated by electrical stimulation (e-stim) subsequently determine...
Extended bed rest or limb immobilization can significantly reduce skeletal muscle mass and function. Recovery may be incomplete, particularly in older adults. Our laboratory recently reported that vascular mural cell (pericyte) quantity is compromised after appropriate replacement immediately before remobilization effectively recover myofiber size mice. Identification of a single surface marker for isolation the most therapeutic pericyte would streamline efforts to optimize recovery. The...
Abstract Regular exercise is crucial for maintaining cognitive health throughout life. Recent evidence suggests muscle contractions during release factors into the blood which cross brain and stimulate adult hippocampal neurogenesis. However, no study has tested whether alone are sufficient to increase neurogenesis improve behavioral performance. Adult male, C57BL/6J mice were anesthetized exposed bilateral hind limb (both concentric eccentric) via electrical stimulation (e-stim) of sciatic...
β-hydroxy β-methylbutyrate (HMB) is a nutritional supplement purported to enhance skeletal muscle mass and strength, as well cognitive function in older adults. The purpose of this study was determine the potential for long-term HMB supplementation preserve cognition aged mice, provide evidence link between vessel-associated pericyte outcomes. Four- (Adult/Ad) 17 month-old (Aged/Ag) C57BL/6J mice consumed chow containing 600 mg/kg BW/day either Ca-HMB (Ad, n=16; Ag, n=17) or Ca-Lactate 6...
Abstract Anabolic resistance to a mechanical stimulus may contribute the loss of skeletal muscle mass observed with age. In this study, young and aged mice were injected saline or human LM-111 (1 mg/kg). One week later, myotendinous junction gastrocnemius was removed via myotenectomy (MTE), thus placing chronic on remaining plantaris for 2 weeks. increased α7B integrin protein expression clustering near DAPI+ nuclei in response MTE. reduced CD11b+ immune cells, enhanced repair, improved...
The goal of this study was to evaluate if combinations ingredients with known anti-cachexia benefits (Fish oil-FO either curcumin or Green tea extract-GTE), have adverse effects on tumor growth, using human carcinoma xenograft mice models. FO (EPA/DHA 360 mg/kg bw), GTE (90 and (180 bw) were administered orally, alone in combination, nude bearing A549 non-small cell lung SW620 colon tumors. Bodyweight, survival time, other clinical endpoints assessed. well tolerated both tumor-bearing mice....
Radiation-induced oral mucositis (RIOM) is a painful, dose-limiting toxicity in cancer therapy. RIOM was induced by radiation on the left buccal pouch mucosa of Golden Syrian hamsters (n = 8/group). Animals were treated topically with polyphenols (Curcumin or Quercetin) amino acids/metabolite mixtures (Alanyl-Glutamine Arginine + Glutamine β-Hydroxy β-methylbutyric acid (Arg/Gln/HMB)) for over 20 day. Progression assessed using standard visual scoring six-point scale, differences severity...
Vaccination against infectious diseases has been one of the most successful public health interventions and several research have shown that acute eccentric exercise augments antibody response to vaccination in humans. However, underlying mechanisms are unclear animal models useful understand purported exercise-induced augmentation responses vaccination. PURPOSE: To determine if could improve primary a suboptimal dose mice. METHODS: In first experiment, mice were exercised at 17m/min speed...
Deficits to cognition and skeletal muscle strength are common in the geriatric population. These deficits worsen over time, result a significant decrease one’s quality of life. Thus, developing therapies that can combat these deficiencies is paramount. Beta-hydroxy-beta-methylbutyrate (HMB) nutritional supplement shown enhance with recent evidence suggesting beneficial effect long-term HMB supplementation on cognition. However, specific mechanisms behind improvements unclear. Perivascular...
Objectives Sarcopenia is the progressive decline in muscle mass, strength and function that exacerbated with age. It well known there an overlap between sarcopenia osteopenia/osteoporosis aging population. Thus, addressing both bone loss during important. Epigallocatechin gallate (EGCg) most abundant green tea catechin has established anti‐inflammatory antioxidant benefits. Green consumption also been associated health. In this study we examined impact of chronic EGCg treatment on mass...
Our laboratory recently reported a significant decline in muscle-resident pericyte quantity following hindlimb immobilization, and subsequently demonstrated the capacity for transplantation to accelerate recovery of skeletal muscle mass during rehabilitation period. PURPOSE: The purpose this study was determine extent which pericyte-derived extracellular vesicles (EVs) effectively recover immobilization. METHODS: Two groups donor mice (n=6/group) were used isolate serum EVs before (“Pre”)...
Significant loss in skeletal muscle mass and function can occur following periods of extended bed rest or immobilization. Physical therapy is recommended, but recovery may be incomplete special populations due to injury functional limitations. Our lab recently demonstrated the capacity for pericytes, vascular stromal cells, accelerate disuse a mouse model. Different pericyte exist based on localization unique cell surface markers, yet most therapeutic population has not been identified....