A5023092170- Viral Infections and Outbreaks Research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Viral Infections and Vectors
- Long-Term Effects of COVID-19
- SARS-CoV-2 detection and testing
- COVID-19 and Mental Health
- Disaster Response and Management
- HIV/AIDS Research and Interventions
- Animal Virus Infections Studies
- HIV, Drug Use, Sexual Risk
- Fire effects on ecosystems
- COVID-19 Impact on Reproduction
- Hepatitis C virus research
- Vector-Borne Animal Diseases
- Global Security and Public Health
- Respiratory viral infections research
- Hepatitis B Virus Studies
- Intensive Care Unit Cognitive Disorders
- Intimate Partner and Family Violence
- Disaster Management and Resilience
- Agricultural risk and resilience
- Enterobacteriaceae and Cronobacter Research
- Gastrointestinal motility and disorders
- Multiple Sclerosis Research Studies
Columbia University
2020-2025
Columbia University Irving Medical Center
2019-2025
Centers for Disease Control and Prevention
2016-2022
New York Hospital Queens
2022
NewYork–Presbyterian Hospital
2022
New York City Department of Health and Mental Hygiene
2020-2021
ICAP Global Health
2020
National Center for Emerging and Zoonotic Infectious Diseases
2020
The Summary of Notifiable Infectious Diseases and Conditions-United States, 2014 (hereafter referred to as the summary) contains official statistics, in tabular graphic form, for reported occurrence nationally notifiable infectious diseases conditions United States 2014. Unless otherwise noted, data are final totals June 30, 2015. These statistics collected compiled from reports sent by U.S. state territory, New York City, District Columbia health departments National Surveillance System...
Ebola virus has been detected in semen of disease survivors after recovery. Liberia's Men's Health Screening Program (MHSP) offers testing for virus. We present preliminary results and behavioural outcomes from the first national programme virus.The MHSP operates out three locations Liberia: Redemption Hospital Montserrado County, Phebe Bong Tellewoyan Lofa County. Men aged 15 years older who had an treatment unit discharge certificate are eligible inclusion. Participants' samples were...
SARS-CoV-2 continues to evolve and spread around the world, it remains critical understand functional consequences of mutations that lead dominant viral variants. KP.3.1.1 is currently most prevalent subvariant worldwide, while recombinant XEC exhibiting fastest growth rate. Here we measured in vitro neutralization by human sera, monoclonal antibodies, soluble hACE2 receptor relative their parental subvariants KP.3 JN.1. were slightly more resistant (1.3-1.6-fold) than serum neutralization,...
Rift Valley fever (RVF) is a zoonotic disease caused by virus (RVFV) found in Africa and the Middle East. Outbreaks can cause extensive morbidity mortality humans livestock. Following diagnosis of two acute human RVF cases Kabale district, Uganda, we conducted serosurvey to estimate RVFV seroprevalence livestock identify associated risk factors.Humans animals at abattoirs villages district were sampled. Persons interviewed about exposure factors. Human blood was tested for anti-RVFV IgM IgG,...
A developing finding from the novel coronavirus 2019 (COVID-19) pandemic is burden of neuropsychiatric symptoms seen in COVID-19 survivors. While studies have shown clinically significant rates depression, anxiety, insomnia, and trauma-related such as post-traumatic stress disorder (PTSD) after COVID-19, little known about how these evolve over time. Here, we report findings a cohort study 52 participants recruited greater New York City area following acute infection. Participants completed...
Whether solid organ transplant (SOT) recipients are at increased risk of poor outcomes due to COVID-19 in comparison the general population remains uncertain. In this study, we compared SOT and non-SOT patients hospitalized with a propensity score matched analysis based on age, race, ethnicity, BMI, diabetes, hypertension. After matching, 117 350 were evaluated. The median age was 61 years, time from 5.68 years. most common transplanted organs kidney (48%), followed by lung (21%), heart...
An estimated 15%-29% of patients report new gastrointestinal (GI) symptoms after coronavirus-19 disease (COVID-19) while 4%-31% depressive symptoms. These may be secondary to gut microbiome tryptophan metabolism and 5-hydroxytryptamine (5-HT)-based signaling.This study used specimens from 2 patient cohorts: (i) fecal samples with acute COVID-19 who participated in a randomized controlled trial testing prebiotic fiber (ii) blood COVID-19. Six months recovering COVID-19, both cohorts answered...
Abstract Although emerging data have revealed the critical role of memory CD8 + T cells in preventing and controlling SARS-CoV-2 infection, virus-specific T-cell responses against its innate-like subsets unvaccinated COVID-19 patients with various disease manifestations an HLA-restricted fashion remain to be understood. Here, we show strong association protective cellular immunity mild unique cell types virus HLA-A2 restricted manner. ELISpot assays reveal that SARS-CoV-2-specific are...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve and spread, it remains critical understand the functional consequences of mutations in dominant viral variants. The recombinant JN.1 subvariant XEC recently replaced KP.3.1.1 become most prevalent worldwide. Here, we measure vitro neutralization by human sera, monoclonal antibodies, soluble ACE2 (hACE2) receptor relative parental subvariants KP.3 JN.1. are slightly more resistant (1.3- 1.6-fold) than serum...
To characterise the long-term outcomes of patients with COVID-19 admitted to a large New York City medical centre at 3 and 6 months after hospitalisation describe their healthcare usage, symptoms, morbidity mortality.
In December 2016, the Wisconsin Department of Health Services (WDHS) notified CDC a patient hospitalized with fever, leukopenia, elevated transaminases, and proteinuria. The owned operated an in-home rattery, or rat-breeding facility, approximately 100 Norway rats, primarily bred as pets. A family member developed similar symptoms 4 weeks later, but was not hospitalized. Because both patients were known to have rodent contact, they tested for hantavirus infections. January 2017, confirmed...
Abstract Background During 2017, a multistate outbreak investigation occurred after the confirmation of Seoul virus (SEOV) infections in people and pet rats. A total 147 humans 897 rats were tested. Methods In addition to immunoglobulin (Ig)G IgM serology traditional reverse-transcription polymerase chain reaction (RT-PCR), novel quantitative RT-PCR primers/probe developed, whole genome sequencing was performed. Results Seventeen had SEOV IgM, indicating recent infection; 7 reported symptoms...
Ebola virus is known to persist in semen of male survivors disease (EVD). However, maximum duration of, or risk factors for, persistence are unknown. We report an EVD survivor with preexisting HIV infection, whose was positive for RNA 565 days after recovery from EVD.
Background Tocilizumab, an interleukin-6 receptor blocker, has been used in the inflammatory phase of COVID-19, but its impact independent corticosteroids remains unclear patients with severe disease. Methods In this retrospective analysis COVID-19 admitted between March 2 and April 14, 2020 to a large academic medical center New York City, we describe outcomes associated tocilizumab 400 mg (without methylprednisolone) compared propensity-matched control. The primary endpoints were change...
Rift Valley Fever virus (RVF) is a zoonotic in the Phenuiviridae family. RVF outbreaks can cause significant morbidity and mortality humans animals. Following diagnosis of two cases March 2016 southern Kabale district, Uganda, we conducted knowledge, attitudes practice (KAP) survey to identify knowledge gaps at-risk behaviors related RVF.A multidisciplinary team interviewed 657 community members, including abattoir workers, around District, Uganda. Most participants (90%) had most (77%)...
On March 9, 2016, a male butcher from Kabale District, Uganda, aged 45 years, reported to the Regional Referral Hospital with fever, fatigue, and headache associated black tarry stools bleeding nose. One day later, student 16 years different sub-county in District developed similar symptoms was admitted same hospital. The also had history of contact livestock. Blood specimens collected both patients were sent for testing Marburg virus disease, Ebola Rift Valley fever (RVF), Crimean Congo...
Background HIV self-tests increase status awareness by providing convenience and privacy, although cost access may limit use. Since 2015, the New York City (NYC) Health Department has conducted 5 waves of an online Home Test Giveaway. Methods We recruited adult cisgender men who have sex with (MSM) transgender gender-nonconforming (TGNC) individuals had men, were living in NYC, not previously diagnosed, using paid digital advertisements (4–8 weeks per wave). Eligible respondents e-mailed a...
We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in with severe disease. Likewise, mean neutralization titers against pseudovirus live virus sicker patients, by ~5-fold ~7-fold, respectively. These findings have important implications for those pursuing therapy, isolation neutralizing monoclonal antibodies, determinants immunity.
We report severe acute respiratory syndrome coronavirus 2 in semen by using quantitative reverse transcription PCR during the late convalescent phase. Virus was associated with adequate humoral and cell-mediated responses, suggesting possible seeding of immune-privileged testes. provide longitudinal quality data for 6 other men, including 3 who had oligozoospermia.
According to World Health Organization (WHO) data, the Ebola virus disease (Ebola) outbreak that began in West Africa 2014 has resulted 28,603 cases and 11,301 deaths (1). In March 2015, epidemiologic investigation genetic sequencing Liberia implicated sexual transmission from a male survivor, with detected by reverse transcription-polymerase chain reaction (RT-PCR) 199 days after symptom onset (2,3), far exceeding 101 reported an earlier (4). response, WHO released interim guidelines...
Unlike immunocompetent hosts, the duration of viral persistence after infection with severe acute respiratory syndrome coronavirus 2 can be prolonged in immunosuppressed patients. Here, we present a case for over 19 weeks patient history solid organ transplant and explore clinical, virologic, immunologic course. Our still demonstrated at 138 days low polymerase chain reaction cycle threshold values evidence continuing sequence evolution indicative ongoing virus replication. These findings...
Efforts to end the HIV and hepatitis C virus (HCV) epidemics begin with ascertainment of a person's infection status through screening. Despite its importance as site testing, missed opportunities for screening in Emergency Department (ED) are common. We describe impact implementing an individualized provider feedback intervention on HCV testing quaternary ED. conducted interrupted time series analysis evaluate weekly observational cohort patients seeking care The included physician champion...