A5069535460- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Animal Disease Management and Epidemiology
- Fire effects on ecosystems
- Mosquito-borne diseases and control
- Influenza Virus Research Studies
- SARS-CoV-2 detection and testing
- Salmonella and Campylobacter epidemiology
- Viral gastroenteritis research and epidemiology
- Vibrio bacteria research studies
- SARS-CoV-2 and COVID-19 Research
- Hepatitis Viruses Studies and Epidemiology
- Vector-Borne Animal Diseases
- Bacteriophages and microbial interactions
- Fish Ecology and Management Studies
- Cell Image Analysis Techniques
- CRISPR and Genetic Engineering
- Single-cell and spatial transcriptomics
- Viral Infections and Immunology Research
- Infection Control and Ventilation
- Animal Virus Infections Studies
- Hepatitis B Virus Studies
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Gene expression and cancer classification
The University of Melbourne
2021-2024
Peter Doherty Institute
2021-2024
Centers for Disease Control and Prevention
2019-2020
Presbyterian Hospital
2019
Southampton Hospital
2019
New York Hospital Queens
2019
NewYork–Presbyterian Hospital
2019
Cornell University
2019
Stony Brook University
2019
Icahn School of Medicine at Mount Sinai
2019
Introduction In October 2017, a blood sample from resident of Kween District, Eastern Uganda, tested positive for Marburg virus. Within 24 hour confirmation, rapid outbreak response was initiated. Here, we present results epidemiological and laboratory investigations. Methods A district task force activated consisting specialised teams to conduct case finding, management isolation, contact listing follow up, collection testing, community engagement. An ecological investigation also carried...
In March 2016, an outbreak of Rift Valley fever (RVF) was identified in Kabale district, southwestern Uganda. A comprehensive investigation initiated, including human, livestock, and mosquito vector investigations. Overall, four cases acute, nonfatal human disease were identified, three by RVF virus (RVFV) reverse transcriptase polymerase chain reaction (RT-PCR), one IgM IgG serology. Investigations cattle, sheep, goat samples from homes villages confirmed probable the central abattoir found...
Despite near-annual human outbreaks of Nipah virus (NiV) disease in Bangladesh, typically due to individual spillover events from the local bat population, only twenty whole-genome NiV sequences exist humans and ten bats. annual have been challenging generate, primarily low viral load throat swab serum specimens. Here, we used targeted enrichment with custom NiV-specific probes generated thirty-five additional unique full-length genomic directly specimens isolates. We inferred temporal...
Abstract Background During 2017, a multistate outbreak investigation occurred after the confirmation of Seoul virus (SEOV) infections in people and pet rats. A total 147 humans 897 rats were tested. Methods In addition to immunoglobulin (Ig)G IgM serology traditional reverse-transcription polymerase chain reaction (RT-PCR), novel quantitative RT-PCR primers/probe developed, whole genome sequencing was performed. Results Seventeen had SEOV IgM, indicating recent infection; 7 reported symptoms...
In the United States (U.S.), hantavirus pulmonary syndrome (HPS) and non-HPS infection are nationally notifiable diseases. Criteria for identifying human cases based on clinical symptoms (HPS or non-HPS) acute diagnostic results (IgM+, rising IgG+ titers, RT-PCR+, immunohistochemistry (IHC)+). Here we provide an overview of testing summarize Hantavirus disease occurrence genotype distribution in U.S. from 2008 to 2020.
In this study, we used whole genome sequencing and comparative genomics analyses to characterize the population structure, evolutionary origins, genomic features of S. Typhi associated with decades endemic typhoid fever in Samoa.
ABSTRACT Hepatitis A virus (HAV) infections are an increasing public health concern in low-endemicity regions due to outbreaks from food-borne and sustained transmission among vulnerable groups, including persons experiencing homelessness, those who inject drugs, men have sex with men, which is further compounded by aging, unvaccinated populations. DNA sequence characterization of HAV for source tracking performed comparing small subgenomic the virus. While this approach has been successful...
Abstract The current panzootic of high pathogenicity avian influenza virus H5N1 demonstrates how viral incursions can have major ramifications for wildlife and domestic animals. Herein, we describe the recent incursion into Australia two low subtypes, H4 H10, that exhibited contrasting evolutionary dynamics. Viruses detected from national surveillance disease investigations between 2020-2022 revealed 27 genomes, 24 which at least one segment more closely related to Eurasian or North American...
Abstract Genomic sequencing’s adoption in public health laboratories (PHLs) for pathogen surveillance is innovative yet challenging, particularly the realm of bioinformatics. Low- and middle-income countries (LMICs) face increased difficulties due to supply chain volatility, workforce training, unreliable infrastructure such as electricity internet services. These challenges also extend high-income (HICs) where bioinformatics nascent PHLs hampered by a lack specialized skills computational...
Abstract The current panzootic of high pathogenicity avian influenza virus H5N1 demonstrates how viral incursions can have major ramifications for wildlife and domestic animals. Herein, we describe the recent incursion into Australia two low subtypes, H4 H10, that exhibited contrasting evolutionary dynamics. Viruses detected from national surveillance disease investigations between 2020 2022 revealed 27 genomes, 24 which at least one segment more closely related to Eurasian or North American...
Australia is a sink for low pathogenicity avian influenza viruses, with isolated circulation occurring on the continent. We report incursion of Eurasian H5 virus into Australia. This benefits surveillance and diagnostic work because risk current absence highly pathogenic A(H5N1).
Abstract The COVID-19 pandemic has necessitated the rapid development and implementation of whole genome sequencing (WGS) bioinformatic methods for managing pandemic. However, variability in capabilities between laboratories posed challenges ensuring data accuracy. A national working group comprising 18 laboratory scientists bioinformaticians from Australia New Zealand was formed to improve concordance across public health (PHLs). One effort, presented this study, sought understand impact...
The COVID-19 pandemic has necessitated the rapid development and implementation of whole-genome sequencing (WGS) bioinformatic methods for managing pandemic. However, variability in capabilities between laboratories posed challenges ensuring data accuracy. A national working group comprising 18 laboratory scientists bioinformaticians from Australia New Zealand was formed to improve concordance across public health (PHLs). One effort, presented this study, sought understand impact methodology...
Temporal differences in culturable severe acute respiratory coronavirus virus 2 (SARS-CoV-2) from the and gastrointestinal tracts a patient with moderate disease 2019 (COVID-19) - Volume 43 Issue 9
ABSTRACT For decades, the remote island nation of Samoa (pop. ~200,000) has faced endemic typhoid fever despite improvements in water quality, sanitation, and economic development. We recently described epidemiology from 2008-2019 by person, place, time; however, local Salmonella enterica serovar Typhi ( S. Typhi) population structure, evolutionary origins, genomic features remained unknown. Herein, we report whole genome sequence analyses 306 isolates collected between 1983 2020....
Abstract Hepatitis A virus (HAV) infections are an increasing public health concern in low-endemicity regions due to outbreaks from foodborne and sustained transmission among vulnerable groups, including persons experiencing homelessness, those who inject drugs, men have sex with (MSM), which is further compounded by aging, unvaccinated populations. DNA sequence characterisation of HAV for source tracking performed comparing small subgenomic the virus. While this approach has been successful...