A5078392348- Catalytic C–H Functionalization Methods
- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Synthesis and Catalytic Reactions
- Epigenetics and DNA Methylation
- Crystallization and Solubility Studies
- Synthesis and Biological Evaluation
- Cancer therapeutics and mechanisms
- X-ray Diffraction in Crystallography
- Phytoestrogen effects and research
- Lung Cancer Treatments and Mutations
- Chemical Reaction Mechanisms
- Cancer Mechanisms and Therapy
- Metal-Organic Frameworks: Synthesis and Applications
- Sulfur-Based Synthesis Techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- PARP inhibition in cancer therapy
- Fluorine in Organic Chemistry
- Low-power high-performance VLSI design
- Chemokine receptors and signaling
- Hip disorders and treatments
- Asymmetric Synthesis and Catalysis
- Hybrid Renewable Energy Systems
- Advanced Breast Cancer Therapies
- Carbon dioxide utilization in catalysis
Collaborative Innovation Center of Chemistry for Energy Materials
2025
Xiamen University
2025
Shenzhen Bay Laboratory
2021-2024
Shenzhen Institute for Drug Control
2021-2023
Jinan University
2021-2023
Lianyungang Maternal and Children’s Hospital
2021-2022
Tsinghua University
2019-2021
University Town of Shenzhen
2021
Lishui City People's Hospital
2016-2020
National University of Defense Technology
2017
Abstract The existing conventional treatments for breast cancer, including immune checkpoint blockade, exhibit limited effects in some cancers, particularly triple-negative cancer. Epigenetic alterations, specifically DNMT and HDAC are implicated cancer pathogenesis. We demonstrated that DNMTs HDACs overexpressed positively correlated combination of inhibitors has shown synergistic antitumour effects, our previously designed dual inhibitor (termed DNMT/HDACi) 15a potently inhibits cell...
Here, a novel strategy for the preparation of ultra-stable gold nanoparticles was developed based on core-shell structure single-molecule micelles, which offered advantages such as convenience, rapid preparation, size control. These enable specific miRNA detection, facilitating precise screening tumor cells.
Gene editing technology based on clustered regularly interspaced short palindromic repeats/associated protein (CRISPR/Cas) systems serves as an efficient tool in cancer therapy. Tracking the gene process can help identify progress of treatment. However, existing techniques for monitoring rely lysed cells, which not reflect dynamic changes nucleic acid living cells. It urgently needs in‐situ and real‐time imaging technologies to track at single cell level more effectively precisely. Here, we...
Gene editing technology based on clustered regularly interspaced short palindromic repeats/associated protein (CRISPR/Cas) systems serves as an efficient tool in cancer therapy. Tracking the gene process can help identify progress of treatment. However, existing techniques for monitoring rely lysed cells, which not reflect dynamic changes nucleic acid living cells. It urgently needs in‐situ and real‐time imaging technologies to track at single cell level more effectively precisely. Here, we...
Abstract A Y(OTf) 3 ‐catalyzed [3+2] cycloaddition of 1,3,5‐triazinanes with donor‐acceptor aziridines has been developed, accessing diversely substituted imidazolidines high efficiency. Mechanistic investigations support the formation through an S N 1‐like pathway. Furthermore, these exhibit promising anti‐tumor activity against a series human cancer cell lines. magnified image
Abstract A first catalytic enantioselective intermolecular radical aminotrifluoromethylation of alkene with hydrazine and Togni's reagent by Cu(I)/CPA cooperative catalysis has been reported, accessing diversely substituted CF 3 ‐containing enantioenriched diarylmethylamines bearing an α ‐tertiary stereocenter high enantioselectivity excellent chemoselectivity. The highly asymmetric induction C−N bond formation between the carbocation intermediate was achieved using a CPA catalyst via...
In recent years, it has been proposed that c-mesenchymal-to-epithelial transition factor (c-Met) and histone deacetylase (HDAC) dual inhibition is a promising cancer treatment strategy. Herein, series of c-Met/HDAC inhibitors were designed synthesized given their synergistic anticancer effect in breast cells. Compound
This study aimed to explore the cost-effectiveness of etanercept plus methotrexate (ETN+MTX) compared triple disease-modifying anti-rheumatic drugs (DMARDs) in treating Chinese rheumatoid arthritis (RA) patients.The 134 RA patients who were about initiate ETN+MTX or DMARDs therapy based on treat-to-target strategy consecutively recruited and categorized into group (N = 49) 85). Treatment efficacy was assessed at month 3 (M3)/M6/M9/M12 after initiation treatment. Also, 1-year treatment cost...
The optimal design of grid-connected Hybrid Renewable Energy Systems (HRESs) is studied by using multi-objective evolutionary algorithm in this paper. With the total system cost and fuel emissions to be minimized, a two-objective optimization model hybrid established. Then, modifi ed preference-inspired co-evolutionary is, for first time, applied fi nd con guration grid-connectedhybrid system. As an example, system, including PV panels, wind turbines, diesel generators, has been designed...
The purpose was to explore the clinical effects and safety of gemcitabine plus nedaplatin in treatment advanced nasopharyngeal carcinoma.From March 2014 August 2015, we recruited 63 carcinoma patients our hospital. Moreover, 62 cases were randomly divided into control group (n = 31) 32). Patients groups treated with 5-fluorouracil 500 mg/m 2 + ml 0.9% sodium chloride injection intervenous drop infusion day 1-5 cisplatin 20 21 days per cycle for 3 cycles; given 1000 1 8 cycles. objective...
In recent years, it has been proposed that c-mesenchymal-to-epithelial transition (c-Met) and histone deacetylase (HDAC) dual inhibition is a promising cancer treatment strategy. Herein, series of c-Met/HDAC inhibitors were designed synthesized, given the synergistic anticancer effect in breast cells. Compound 12d exhibited highest potential cytotoxic activity against all three cell lines displayed excellent inhibitory c-Met (IC50 = 28.92 nM) HDAC (85.68%@1000 nM). Mechanism research showed...
Abstract TfOH‐catalyzed [3+2] cycloaddition of donor‐acceptor oxiranes with isothiocyanates via chemoselective C−O bond breakage D−A was developed under metal‐ and additive‐free conditions. This method providing a facile access to diverse range highly substituted 1,3‐oxathiolane‐2‐imines in good excellent yields high Z ‐selectivity functional group tolerance. In addition, the established protocol can be easily scaled up gram level yield. Furthermore, transformation cycloadduct into...
α-Substituted peroxides have been found in natural products and are widely used as anti-malarial agents. Zn(OTf)2 -catalyzed peroxidation of 1,3,5-triazines has developed, accessing diversely substituted α-amino tertiary alkylperoxides with high efficiency. Mechanistic investigations useful synthetic application the also presented.
Jiao and co-workers reported the synthesis of indoles from anilines alkynes by a C-H activation process catalyzed Pd(OAc)2 which uses dioxygen as oxidant in catalytic cycle. The best results were obtained when using mixture DMA pivaloic acid (PivOH) solvent. scope reaction was well studied. Thus, both EWGs EDGs starting tolerated whereas only electron-deficient afforded corresponding modest to good yields. In addition, N-monosubstituted participated efficiently reaction.