A5054506971- Pregnancy and preeclampsia studies
- MicroRNA in disease regulation
- Genomics and Phylogenetic Studies
- Fungal Biology and Applications
- Birth, Development, and Health
- Chemical Synthesis and Characterization
- Radiomics and Machine Learning in Medical Imaging
- Zeolite Catalysis and Synthesis
- Reproductive System and Pregnancy
- Mycorrhizal Fungi and Plant Interactions
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Plant Molecular Biology Research
- Cancer-related molecular mechanisms research
- Chemokine receptors and signaling
- Medical Image Segmentation Techniques
- PARP inhibition in cancer therapy
- Biological and pharmacological studies of plants
- Galectins and Cancer Biology
- Plant responses to water stress
- Single-cell and spatial transcriptomics
- Advanced Neural Network Applications
- RNA modifications and cancer
- Clay minerals and soil interactions
- Infection Control and Ventilation
Chengdu University of Traditional Chinese Medicine
2025
Taiyuan University of Science and Technology
2023-2025
Fujian Jiangxia University
2023-2025
BGI Genomics
2020-2024
BGI Group (China)
2020-2024
Tsinghua University
2021
Huawei Technologies (China)
2020
Affiliated Hospital of Guizhou Medical University
2018
Guiyang Medical University
2018
Abstract Dendrobium huoshanense is used to treat various diseases in traditional Chinese medicine. Recent studies have identified active components. However, the lack of genomic data limits research on biosynthesis and application these therapeutic ingredients. To address this issue, we generated first chromosome-level genome assembly annotation D. huoshanense. We integrated PacBio sequencing data, Illumina paired-end Hi-C assemble a 1.285 Gb genome, with contig scaffold N50 lengths 598 kb...
The mechanisms by which low light modulates source-sink dynamics, affecting starch synthesis and formation of underground storage organs in geophyte, remain unclear. In this study, a two-year field experiment was conducted under natural (NL) (LL, 50% NL intensity) conditions. LL resulted 23.66% 21.23% reduction corm yield 2023 2024, respectively. Saffron plants had larger, longer leaves with higher proportion dry weight (DW) compared to those NL. Despite the marked inhibition photosynthetic...
Abstract Background Preeclampsia (PE) is a serious pregnancy complication that can adversely affect the mother and fetus. Necroptosis recently discovered new form of programmed cell death involved in pathological process various complications. Our study aimed to identify necroptosis-related differentially expressed genes (NRDEGs), create diagnosis model related disease subtypes based on these genes, further investigate their relationship with immune infiltration. Methods In this study, we...
We developed and validated a multimodal radiomic machine learning approach to noninvasively predict the expression of lymphocyte cell-specific protein-tyrosine kinase (LCK) clinical prognosis patients with high-grade serous ovarian cancer (HGSOC). analyzed gene enrichment using 343 HGSOC cases extracted from The Cancer Genome Atlas. corresponding biomedical computed tomography images accessed Imaging Archive were used construct signature (Radscore). A nomogram was built by combining Radscore...
Gastric cancer (GC), one of the most common cancers worldwide, presents a considerable threat to human health. Although multiple investigations have been made figure out therapies for this disease, prognosis patients suffered from GC remains poor. It has reported that lncRNAs exerted their significant effects on numerous cancers. Evidence confirmed lncRNA RGMB-AS1 played an oncogenic role in progression However, biological function and molecular mechanism haven't explored. In study, our...
Abstract A Y(OTf) 3 ‐catalyzed [3+2] cycloaddition of 1,3,5‐triazinanes with donor‐acceptor aziridines has been developed, accessing diversely substituted imidazolidines high efficiency. Mechanistic investigations support the formation through an S N 1‐like pathway. Furthermore, these exhibit promising anti‐tumor activity against a series human cancer cell lines. magnified image
Abstract Purpose This study aims to explore the contribution of differentially expressed programmed cell death genes (DEPCDGs) heterogeneity serous ovarian cancer (SOC) through single-cell RNA sequencing (scRNA-seq) and assess their potential as predictors for clinical prognosis. Methods SOC scRNA-seq data were extracted from Gene Expression Omnibus database, principal component analysis was used clustering. Bulk RNA-seq employed analyze SOC-associated immune subsets key genes. CIBERSORT...
Flammulina filiformis is one of the widely produced edible fungi worldwide. It rich in γ-aminobutyric acid (GABA), a non-protein amino with important physiological functions humans. To investigate key genes GABA metabolic pathway F. filiformis, we isolated monokaryon Fv-HL23-1 from factory-cultivated strain Fv-HL23 and then sequenced assembled genome using PacBio Sequel Illumina NovaSeq sequencing platforms. The results showed that comprised 140 scaffolds total length 40.96 Mb, GC content...
Biomedical image segmentation of organs, tissues and lesions has gained increasing attention in clinical treatment planning navigation, which involves the exploration two-dimensional (2D) three-dimensional (3D) contexts biomedical image. Compared to 2D methods, 3D methods pay more inter-slice correlations, offer additional spatial information for segmentation. An organ or tumor a structure that can be observed from three directions. Previous studies focus only on vertical axis, limiting...
Synthesis of zeolite A by the use natural materials (naturally stellerite) has been achieved without template agent. The final product was tested with X-ray diffraction, which identified as A. Then, raw material and each step were Fourier Transformation Infrared (FT-IR). Comparing their FT-IR, we analyzed spectrum characteristics, differences reasons.
To investigate the relationship between expression/amplification of human epidermal growth factor receptor (HER 2)/neu and its clinical significance in colorectal cancer, this study, clinicopathological data paraffin-embedded specimen were collected on 192 consecutive patients who underwent resections from 2001 to 2005 at Renmin Hospital Wuhan University. Using immunohistochemistry fluorescence situ hybridization, HER-2/neu protein overexpression gene amplification detected. HER 2/neu was...
The culinary-medicinal mushroom Grifola frondosa is widely cultivated in East Asia. In this study, the complete mitochondrial genome of G. was determined using Illumina sequencing. circular molecule 197,486 bp length with a content 25.01% GC, which one largest genomes order Polyporales. A total 39 known genes encoding 13 common genes, 24 tRNA 1 ribosomal protein s3 gene (rps3), and DNA polymerase (dpo) were predicted genome. phylogenetic analysis showed that clustered together Sparassis...
Motivation: 3D gradient-echo based liver acceleration volume acquisition (LAVA) sequence is widely used for dynamic contrast imaging in liver. LAVA usually requires breath-holding over 16 seconds, posing a challenge individuals with difficulty prolonged breath-holding. Goal(s): To investigate whether deep learning reconstruction (DLR) allows reduced scan time but without sacrificing image diagnostic quality. Approach: SNR, CNR, and subjective analysis using 5-point Likert scales were...
To evaluate the prognostic significance and molecular mechanism of NETosis markers in ovarian serous cystadenocarcinoma (OSC), we constructed a machine learning-based pathomic model utilizing hematoxylin eosin (H&E) slides. We analyzed 333 patients with OSC from The Cancer Genome Atlas for prognostic-related neutrophil extracellular trap formation (NETosis) genes through bioinformatics analysis. Pathomic features were extracted 54 cases complete pathological images, genetic matrices,...
Background: This study aims to explore the circadian rhythm of interictal epileptiform discharges (IEDs) and changes spindles in patients with temporal lobe epilepsy (TLE). Methods: Subjects were divided into two groups: research group (patients diagnosed TLE, n=50) control (n=30). The whole-night natural sleep all subjects was monitored, analysis statistics performed on IED, number, amplitude average duration compared between these groups. Results: (1) In TLE patients, number IED larger...
Zeolite P was synthesized for hydrothermal route at crystallization temperature of 95°C and time 7h, using“acid-treated stellerite-NaOH-NaAlO 2 -H O” as precursor, with different molar ratios n (SiO /Al O 3 ), (Na O/SiO ) (H O/Na O). The as-fabricated samples were characterized by scanning electron microscopy, X-ray diffraction, FT-IR techniques. result shows that: the crystal structure zeolite has been determined in tetragonal system, lattice constants are 10.049Å,10.047 Å crystallinity is...