A5100378481- Kruppel-like factors research
- Epigenetics and DNA Methylation
- Genetic Syndromes and Imprinting
- Cancer-related gene regulation
- Microtubule and mitosis dynamics
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Metabolomics and Mass Spectrometry Studies
- Bioenergy crop production and management
- Cancer therapeutics and mechanisms
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Morphological variations and asymmetry
- Ferroptosis and cancer prognosis
- Chronic Myeloid Leukemia Treatments
- Ginseng Biological Effects and Applications
- High Altitude and Hypoxia
- Congenital Diaphragmatic Hernia Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- S100 Proteins and Annexins
- CAR-T cell therapy research
- Biomarkers in Disease Mechanisms
- RNA Research and Splicing
- Glutathione Transferases and Polymorphisms
- Mesenchymal stem cell research
Huazhong University of Science and Technology
2009-2025
Tongji Hospital
2025
BeiGene (China)
2024
China Medical University
2008-2023
First Hospital of China Medical University
2023
Sichuan University
2023
Tianjin Medical University General Hospital
2023
The University of Texas MD Anderson Cancer Center
2017-2022
Air Force Medical University
2013-2022
Xijing Hospital
2022
Background: Osteogenic induction and bone formation are heavily affected by environmental factors, including estrogen, estrogen receptors, coregulatory proteins, such as the recently reported proline-, glutamic acid-, leucine-rich protein 1(Pelp1).Objective: To investigate Pelp1 expression in rat mesenchymal stem cells (rBMSCs) during cell proliferation osteogenic differentiation.Methods: rBMSCs were cultured routine differentiation media.Cell was assessed at days 1, 3, 5, 7, 9, 11, 14,...
Purpose: The dismal prognosis of pancreatic cancer has been linked to poor tumor differentiation. However, molecular basis differentiation and potential therapeutic value the underlying molecules remain unknown. We investigated mechanistic underexpression Krüppel-like factor 4 (KLF4) in defined a novel epigenetic pathway its activation for treatment.Experimental Design: Expressions KLF4 DNMT1 tissues were determined by IHC genetic alterations KLF4's impact on examined using biology...
Background: Hypertrophic scars (HS) often occur after burns, surgery and extensive trauma. Krüppel-like factor 4 (KLF4) is a member of the family, group conserved zinc finger transcription factors that regulate diverse cellular processes. KLF4 can participate in regulation fibrotic diseases many organs, such as lung, liver, heart. However, antifibrotic effect skin HS remains elusive. Result: This study observed inhibition on fibrosis vivo vitro. Our results revealed expression was decreased...
Stem cells are fundamental units of tissue remodeling whose functions dictated by lineage-specific transcription factors. Home to epidermal stem and their upward-stratifying progenies, skin relies on its secretory form the outermost protective barrier, which a transcriptional orchestrator has been elusive. KLF5 is Krüppel-like factor broadly involved in development regeneration lineage specificity, if any, remains unclear. Here we report specifically marks epidermis, deletion leads barrier...
Endometrial cancer (UCEC) is one of the most common gynecological malignancies. We previously found that overexpression G protein α subunit 14 (GNA14) promoted UCEC growth. Krüppel-like factor 7 (KLF7) acts as an oncogene in various types, whereas connection between GNA14 and KLF7 unclear. herein explored involvement GNA14/KLF7 development.
Is moonlight 'silver' or 'cold'? In this paper we discuss the interesting combination of factors that contribute to common descriptions moonlight. Sunlight is reflected from lunar surface and red-shifted. When traversing atmosphere, further depleted short wavelength content by Rayleigh scattering. We measured spectra show these effects compared them with sunlight. All measurements, including spectral reflectance, suggest redder than The silvery Moon just an illusion due properties behaviour...
Mutations in human KLF11 may lead to the development of maturity-onset diabetes young 7 (MODY7). This occurs due impaired insulin synthesis pancreas. To date, clinical and functional characteristics novel mutation c.1061G > T have not yet been reported. Whole-exon sequencing was used screen proband family members with suspicion variant. Luciferase reporter assays were investigate whether variant binds promoter. Real-time PCR, western blotting, glucose-stimulated secretion (GSIS) analysis...
Abstract Forest is the most important terrestrial component of Earth's biosphere, containing nearly 80% biodiversity. However, climate change and population growth are exacerbating deforestation forest degradation. Reforestation efforts aim to restore ecosystems, but effectiveness traditional tree plantations in repairing ecological function native forests controversial. The ideal scenario for forestry future meet growing demand products while keeping sustainable development. One possible...
Purposes. To identify the differentially expressed genes (DEGs) related to immune microenvironment and elucidate biological functions of key in papillary thyroid cancer (PTC) by analyzing microenvironment. Methods. The relative quantities matrix components 507 patients with PTC were calculated from TCGA database. Analysis tumor samples throughout genome, intersection DEGs obtained patients, genome-wide survival analysis performed. Survival was used for identification prognostic factor....
The present study aimed to characterize the expression of Krüppel-like factor 8 (KLF8) in nasopahryngeal carcinoma (NPC) cell lines and determine its effect on tumor development invasion following KLF8 gene knockdown by small hairpin RNA (shRNA). four NPC was examined quantitative polymerase chain reaction (qPCR) western blotting. knocked down SUNE1-5-8F/Sh-KLF8 line using shRNA, resulting stable SUNE1-5-8F-sh-KLF8 transplanted into nude mice order observe formation invasion. results...
Ras homologue gene family member A (RhoA) is involved in tumor mobility, invasion, and metastasis. We detected RhoA expression vulvar squamous cell carcinoma (VSCC) tissue, measured the VSCC phenotype, of relevant molecules after small interfering RNA (siRNA) transfection SW962 cells. has a higher level than normal vulva skin tissue was positively associated with International Federation Gynecology Obstetrics (FIGO) stage differentiation; besides, patients lymph node metastasis had positive...
Mitochondrial shape changes are essential to mitochondrial functions. Quantification of is understanding related physiology and disease mechanisms. In this study, we proposed a new automated pipeline for quantifying the changing patterns mitochondria in framework large deformation diffeomorphic metric mapping curve. We validated accuracy our on 32 data, each having 6 sequential time-lapse frames. The contour mitochondrion modeled by curve consisting set landmark points ranging from 39 358,...
Background . BMPER has been reported to be associated with the biological behavior of a few malignant tumors, but mechanism is still unclear. We aimed detect expression in ovarian epithelial tumor tissues and its effects on their behaviors, as well elucidate possible mechanism. Methods was detected by immunohistochemistry. cancer cell lines inhibited via RNA interference. Changes behaviors cells were MTT, wound healing, Transwell, flow cytometry assays. proteins MAPK autophagy-related...
<h3>Background</h3> IL-15 is a promising cytokine for cancer immunotherapy as it preferentially promotes natural killer (NK) and CD8<sup>+</sup> T-cell expansion. However, the clinical use of remains limited due to systemic toxicities narrow therapeutic window. To overcome these limitations, BGB-R046 was developed an pro-drug, which inactive in circulation can be specifically activated at tumor site by utilizing enriched protease. composed IL-15Rα-sushi-IL-15, also named superagonist,...
Klotho gene was originally discovered as an anti-aging gene, protein encoded by is expressed in multiple human tissues, and its most prominent function the regulation of phosphate homeostasis. possesses various activities, including inhibition signaling pathways, reducing oxidative stress suppressing inflammation, these activities are associated with cancer. a universal tumor suppressor, expression tumorigenesis prognosis patients. Lung cancer common malignancy tumor, it leading cause deaths...
Alzheimer's disease is the most common form of dementia and affects human health. In this study, a classic prescription Chinese Medicine Gan-Mai-Da-Zao decoction was used for treating first time. Hence, firstly components in plasma were screened using UPLC-QTOF/MS. Then MWM, HE Metabolomics methods to examine effect on rats. The results showed 9 active ESI+ 3 ESI− blood identified, improved learning memory ability pathological damage 57 metabolites 21 urine returned normal model group after...