A5081850361- Systemic Sclerosis and Related Diseases
- Spondyloarthritis Studies and Treatments
- Psoriasis: Treatment and Pathogenesis
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Therapeutic Uses of Natural Elements
- Inflammatory Myopathies and Dermatomyositis
- Bone and Joint Diseases
- Vasculitis and related conditions
- Ocular Diseases and Behçet’s Syndrome
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Vitamin D Research Studies
- Immunodeficiency and Autoimmune Disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Monoclonal and Polyclonal Antibodies Research
- Bone health and osteoporosis research
- Autoimmune and Inflammatory Disorders Research
- Medication Adherence and Compliance
- Autoimmune and Inflammatory Disorders
- Medical Imaging and Analysis
- S100 Proteins and Annexins
- IgG4-Related and Inflammatory Diseases
- Healthcare Systems and Public Health
- Myofascial pain diagnosis and treatment
- Dermatological and Skeletal Disorders
Hospital Universitario Doctor Peset
2017-2022
Center for Rheumatology
2017
Background: Currently, most authors accept that mixed connective tissue disease (MCTD) is an independent entity, although there are those who argue it actually overlap syndrome or undifferentiated early phase of another systemic autoimmune (SAD). Objectives: To analyze the long term evolution a serie patients with MCTD. Methods: Observational, retrospective and multicenter study in MCTD ( diagnostic criteria Alarcón-Segovia et al), followed for minimun 2 years. Results: Fifty-five (49 women)...
<h3>Background</h3> RA patients have a higher risk of vascular events, especially cardiac ones. Besides, mortality in these is 54% than the general population. Nowadays, we non-invasive techniques that allow us to detect subclinical damage. <h3>Objectives</h3> To describe affection sample and explore its relationship with development events. <h3>Methods</h3> Ambispective observational study analytical components. We included, consecutively, controlled tertiary hospital. gathered demographic...
<h3>Background</h3> Accelerated atherosclerosis (AE) and increased arterial stiffness are comorbidities of rheumatoid arthritis (RA) related to the inflammatory burden disease, as well certain clinical genetic characteristics disease. There is controversy about role ACPA in development AE these patients. <h3>Objectives</h3> To explore relation between RF titres subclinical vascular damage RA <h3>Methods</h3> Descriptive cross-sectional study with analytical components. A total 244 patients...
<h3>Background</h3> Psoriatic arthritis (PsA) is a disease associated with an increased cardiovascular (CV) risk, due to early atherosclerosis, which comparable rheumatoid population. However, there lack of studies that evaluate the progression subclinical atherosclerosis over year in these patients. <h3>Objectives</h3> To explore vascular damage by different techniques patients PsA and factors related changes. <h3>Methods</h3> Pre-post study analytical components. 44 (CASPAR criteria)...
<h3>Background</h3> Antinuclear antibodies (ANA) positivity with a dense fine speckled (DFS) pattern by indirect immunofluorescence (IIF), as per the definition of International Consensus on ANA Patterns (ICAP), is not uncommon and linked to presence anti-DFS70 antibodies. These antibodies, in absence others, are very valuable biomarkers exclusion systemic autoimmune disease (SAD). <h3>Objectives</h3> To evaluate antibody detection two different laboratory techniques its relation IIF...
<h3>Background</h3> The presence of anti-nuclear antibodies (ANA) has been considered a characteristic systemic autoimmune diseases (SAD). Patients are frequently referred for study because they have ANA and followed the possibility to develop SAD. Approximately, 20% healthy individuals with detected by indirect immunofluorescence (IFI), especially at low titers, dense, fine speckled pattern (DFS) that corresponds anti-DFS70 antibodies. importance this antibody is due its prevalence in...
<h3>Background</h3> Plasma d-dimer (DD) has proven to be a reliable marker of systemic prothrombotic state and its measurement might helpful in predicting cardiovascular events even mortality across broad variety diseases. An association between high levels DD macrovascular disease, diffuse cutaneous involvement active disease been suggested patients with SSc. <h3>Objectives</h3> To determine the usefulness as explore relation other features biomarkers <h3>Methods</h3> Descriptive...
<h3>Background</h3> Obesity is a comorbid condition in patients with psoriasis which tends to be less common psoriatic arthritis (PsA). In the general population, obesity associated increased inflammatory load and vascular risk, hypovitaminosis D. <h3>Objectives</h3> To explore relationship between disease activity, damage, serum concentrations of vitamin D (25OHD) bone mineral density (BMD) PsA. <h3>Methods</h3> Descriptive cross-sectional study. Patients PsA peripheral joint involvement...
<h3>Background:</h3> Medication non-adherence has been associated with treatment failure in chronic inflammatory conditions. A positive relationship between patient activation and adherence to improved clinical outcomes shown for <h3>Objectives:</h3> To measure biological therapies targeted synthetic DMARD (tsDMARD), their the Patient Activation Measure (PAM) therapy related factors, arthropathies. <h3>Methods:</h3> Cross-sectional observational descriptive study a general tertiary...
<h3>Background</h3> Patients with psoriatic arthritis (PsA) have a higher prevalence of classical vascular risk factors (CVRF) and early atherosclerosis determined by chronic inflammation. <h3>Objectives</h3> To study the evolution over time different damage evaluation measures in patients PsA investigate related to these changes. <h3>Methods</h3> Pre-post longitudinal analytical components. peripheral joint involvement were included. Demographic (sex, age), clinical [duration disease,...
<h3>Background</h3> Patients with inflammatory rheumatic diseases, such as rheumatoid arthritis (RA) or psoriatic (PsA), have a higher cardiovascular risk than the general population. There are data in other pathologies about role of leukocyte adhesion on endothelial damage. <h3>Objectives</h3> To evaluate relationship between and subclinical vascular damage patients RA PsA. <h3>Methods</h3> Observational, cross-sectional exploratory study. PsA who had at least one previous study were...
<h3>Background:</h3> Some studies indicate that psoriatic arthritis (PsA) patients have increased bone loss due to chronic inflammation, but data in the Spanish population is scarce. <h3>Objectives:</h3> To study evolution over time of mineral density (BMD) with PsA and investigate factors related these changes. <h3>Methods:</h3> We included peripheral joint involvement. They were treated at Doctor Peset University Hospital a 3-year follow-up was carried out. All underwent densitometry...
Background There are increasingly data about the usefulness of calprotectin levels in chronic inflammatory arthritis and its relationship with prognostic factors. However, few available on role diagnosis acute arthritis. Objectives To evaluate possible testing plasma synovial fluid (SF) as a predictor final behind an mono or oligoarthritis. Methods Longitudinal observational study. We included non-consecutive patients referred to rheumatology emergency department suspected oligoarthritis for...
<h3>Background</h3> Patients with chronic inflammatory disease in treatment immunosuppressants have an increased risk of opportunistic infections, including leishmaniasis. <h3>Objectives</h3> To describe a multicenter case series leishmaniasis patients diseases treated immunosuppressants. analyze factors related to the infection. <h3>Methods</h3> Observational retrospective study. We reviewed clinical history immunosuppressants, who were diagnosed between 2007 and 2018. Demographic (age,...
Background: Rituximab (RTX) is effective in improving skin affection patients with diffuse cutaneous systemic sclerosis (DcSSc). However, there are few data on early use of this drug. Objectives: To evaluate RTX effectiveness for disease DcSSc less than 3 years evolution. Methods: Multicenter, observational and retrospective study. Patients starting within since first non-Raynaud symptom were recruited. Demographic variables, time duration at the beginning RTX, immune pattern treatment...
Background: In axial spondyloarthritis (axSpA) the risk of vertebral fracture is increased, not always corresponding with values bone mineral density (BMD). One possible explanation that syndesmophytes interfere these values. We consider whether evaluation trabecular microarchitecture by an accessible methodlike Trabecular Bone Score (TBS), does involve additional irradiation neither seem to be influenced presence syndesmophytes, may advantage estimate fracture. Objectives: To prevalence...
Background: Objectives: To evaluate rituximab (RTX) effectiveness and safety in treating patients with refractory mixed connective tissue disease (MCTD). Methods: Open observational study including MCTD (active despite treatment glucocorticoids csDMARDs) from two third-level hospitals who had been treated RTX (off-label use) January 2001 to December 2019. Results: Thirteen (all women) were included, a mean age of 32 years (SD: 10, range 17-50) median time evolution the 55 months 34.3; 5-98...
Background: Arthritis of viral aetiology is considered the most frequent cause acute arthritis. The common etiologic agent parvovirus B19 (B19). Besides, other viruses can lead to inflammatory joint disease, such as Epstein-Barr virus (EBV), Cytomegalovirus (CMV), Human immunodeficiency (HIV), Rubella, Mumps, Hepatitis B and C (HBV HCV) Chikungunya (in transcontinental travellers or immigrants). Objectives: To describe epidemiological characteristics, clinical analytical course, evolution...
Background: There are few data about variations in bone metabolism associated with weight loss obese patients undergoing bariatric surgery. Objectives: To assess the influence on of surgery morbidly patients. Methods: Longitudinal pre-post study analytical components. All were, prior to this, referred Rheumatology Department. In all cases, baseline characteristics were collected and a complete metabolic densitometry (BMD) requested. This same was repeated one year later, window period ± 3...
Background: Psoriatic arthritis (PsA) is associated with insufficent levels of vitamin D (25OHD) and an increased cardiovascular risk. Several studies, have shown inverse relationship between 25OHD damage. Objectives: To study the vascular damage, as well its possible influence on progression, in patients PsA. Methods: Pre-post longitudinal analytical components. PsA peripheral joint involvement were included. Demographic (sex, age), clinical [follow-up time, DAPSA, current treatment, body...
Background: Treatment of calcinosis associated with systemic sclerosis (SSc) mainly involves the use therapies, which often have limited efficacy. However, little attention has been paid to local treatment, is especially useful when skin ulcers. Objectives: To show our experience topical sodium thiosulfate (TST) for treatment calcinosis-associated cutaneous ulcers in patients SSc. Methods: Descriptive analysis a case series SSc and treated TST. Wound management procedure : wounds...
Background: Initially, anti-Ku antibodies (Ab) were described in patients with overlap syndrome systemic sclerosis (SSc) and inflammatory myophaty (scleromyositis), although later they have been linked to a wide variety of autoimmune diseases (SAD) questioning its diagnostic value. Recently, the possible existence 2 different clinical phenotypes associated these Ab has described: one myositis high risk intersticial lung disease (ILD) another positive anti-dsDNA glomerulonephritis....