A5057550078- Spondyloarthritis Studies and Treatments
- Systemic Sclerosis and Related Diseases
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- COVID-19 and healthcare impacts
- Cytokine Signaling Pathways and Interactions
- Atherosclerosis and Cardiovascular Diseases
- Urticaria and Related Conditions
- Therapeutic Uses of Natural Elements
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Vitamin D Research Studies
- HER2/EGFR in Cancer Research
- Cardiovascular Disease and Adiposity
- Oral Health Pathology and Treatment
- Lipid metabolism and disorders
- SARS-CoV-2 and COVID-19 Research
- Sexual function and dysfunction studies
- Eosinophilic Esophagitis
- Hematological disorders and diagnostics
- Inflammasome and immune disorders
- Bone and Joint Diseases
Hospital Universitario Doctor Peset
2013-2024
Hospital General Universitari de Castelló
2018-2023
Hospital Universitario La Paz
2023
Center for Rheumatology
2013-2021
Hospital Universitario de Valme
2015
Abstract Association between elevated C-reactive protein (CRP) serum levels and subclinical atherosclerosis cardiovascular (CV) events was described in rheumatoid arthritis (RA). CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A SALL1 exert an influence on CRP non-rheumatic Caucasians. Consequently, we evaluated the potential role of these genes development CV RA patients. Three tag polymorphisms were genotyped 2,313 Spanish patients by TaqMan. Subclinical determined 1,298 them...
To investigate the genetic background influencing development of cardiovascular (CV) disease in patients with rheumatoid arthritis (RA).We performed a genome-wide association study (GWAS) which, after quality control and imputation, total 6,308,944 polymorphisms across whole genome were analyzed 2,989 RA European origin. Data on subclinical atherosclerosis, obtained through assessment carotid intima-media thickness (CIMT) presence/absence plaques by ultrasonography, available for 1,355...
To determine whether the interleukin-33 (IL-33)-interleukin-1 receptor like 1 (IL-1RL1) signaling pathway is implicated in risk of subclinical atherosclerosis patients with rheumatoid arthritis (RA).A total 576 Spanish RA from Northern Spain were genotyped for 6 well-known IL33-IL1RL1 polymorphisms (IL33 rs3939286, IL33 rs7025417, rs7044343, IL1RL1 rs2058660, rs2310173 and rs13015714) by TaqMan genotyping assay. The presence was determined assessment carotid intima-media thickness (cIMT)...
Secukinumab is a biologic disease-modifying antirheumatic drug (bDMARD) that has demonstrated efficacy in the treatment of axial spondyloarthritis (axSpA, i.e., ankylosing spondylitis and non-radiographic axSpA) across various clinical trials. However, data secukinumab practice still limited. Here, we aimed to provide real-world on use, effectiveness, persistence axSpA.
Psoriatic arthritis (PsA) is a complex and heterogeneous inflammatory disease. Secukinumab, biologic disease-modifying antirheumatic drug (bDMARD), has extensive clinical evidence of efficacy safety in the treatment PsA but data practice are still limited. This study aims to provide real-world on secukinumab use, effectiveness, persistence PsA.A retrospective, multicenter was conducted patients diagnosed with treated up June 2021 at 12 centers Valencian Community (Spain). Data DAS28-CRP,...
Abstract A genetic component influences the development of atherosclerosis in general population and also rheumatoid arthritis (RA). However, polymorphisms associated with are not always involved cardiovascular disease (CVD) RA. Accordingly, a study North-American RA patients did show association reported coronary artery series relevant ( TCF21, LPA, HHIPL1, RASD1-PEMT, MRPS6, CYP17A1-CNNM2-NT5C2, SMG6-SRR, PHACTR1, WDR12 COL4A1-COL4A2) . In present study, we assessed potential these CVD...
Several descriptive cohort studies of patients affected by COVID-19 have been published.To describe the characteristics with SARS-CoV-2 infection who were admitted to Hospital Universitario la Plana, Castellón, Spain.Retrospective, observational study that included 18-year-old or older consecutively SARS-CoV2 confirmed infection. Demographic characteristics, comorbidities, clinical symptoms, laboratory results and radiological tests are described.The 255 a mean age 70 years; 54.9 % males....
Background:Several descriptive cohort studies of patients affected by COVID-19 have been published.Objective: To describe the characteristics with SARS-CoV-2 infection who were admitted to Hospital Universitario la Plana, Castellón, Spain.Methods: Retrospective, observational study that included 18-year-old or older consecutively SARS-CoV2 confirmed infection.Demographic characteristics, comorbidities, clinical symptoms, laboratory results and radiological tests are described.Results: The...
Background Chronic joint diseases impair the quality of life. This occurs not only by deformity generated, but also pain and disability produced them (1, 2) . There are a limited number studies on sexuality (3, 4) Besides, many lack control group do explore different areas (1-4) Objectives To describe prevalence sexual dysfunction (SD) in patients with rheumatoid arthritis (RA) psoriatic (PA). compare results obtained between two healthy population. analyse factors associated SD 3...
<h3>Background:</h3> Hematological indices, such as neutrophil-to-lymphocyte (NLR), platelets-to-lymphocyte (PLR), lymphocyte-to-monocyte (MLR), lymphocyte-to-C-reactive protein (LCR) and platelet-to-neutrophil (PNR) ratios; have been proposed potential prognostic biomarkers for cardiovascular diseases. Rheumatoid arthritis (RA) is an inflammatory chronic joint disease known to increase risk early atherosclerosis. <h3>Objectives:</h3> To evaluate the association of hematological indices:...
<h3>Background:</h3> Systemic autoimmune diseases, including systemic sclerosis (SSc), are associated with early atherosclerosis. Hematological indices, such as: Neutrophil-Lymphocyte Ratios (NLR), Platelet-Neutrophil (PNR) and Platelet-Lymphocyte (PLR), related to inflammation In SSc, NLR could predict disease progression mortality. <h3>Objectives:</h3> To evaluate the potential value of baseline NLR, PNR PLR determination as predictors subclinical vascular damage (atherosclerosis), major...
<h3>Background:</h3> Systemic sclerosis (SSc) is a disease with high morbidity and mortality. As other autoimmune systemic diseases, it associated early atherosclerosis increased cardiovascular risk. Nailfold capillaroscopy widely use method for the diagnosis monitoring of SSc. <h3>Objectives:</h3> To describe frequency subclinical vascular damage, major adverse events (MACEs) mortality in cohort patients analyse association predictive value nailfold at time diagnosis, MACEs deaths....
<h3>Background</h3> Interleukin 6 (IL6) has been associated with modified Rodnan Skin Score (mRSS), interstitial lung disease (ILD), anti-Scl70 and anti-RNA polymerase III antibodies, as well ischemic digital ulcers (IDU) pulmonary hypertension (PH) in patients Systemic Sclerosis (SSc). <h3>Objectives</h3> To evaluate the usefulness of determining plasma IL6 SS, a marker vascular disease. investigate its association other clinical manifestations biological markers SS. <h3>Methods</h3>...
<h3>Background</h3> Non-adherence to antiretroviral treatment (ART) regimens is closely related failure and in response, researchers have developed interventions improve adherence. <h3>Purpose</h3> To determine the effect of sending mobile phone text messages remind patients get more medicines on adherence ART HIV-infected patients. <h3>Material methods</h3> This was an interventional study carried out outpatients who got their from a hospital pharmacy service during 2012. The intervention...
<h3>Background</h3> Interstitial lung disease (ILD) is a serious complication of rheumatoid arthritis (RA) and different systemic autoimmune diseases. A multidisciplinary management allows optimizing handling can help reducing its high morbidity mortality. <h3>Objectives</h3> To describe the characteristics cohort patients with rheumatic disease-associated ILD (RHEU-ILD) controlled in specific consultation Pulmonology-Rheumatology, to evaluate changes produced by joint activity on diagnosis...
<h3>Background</h3> Analysis of arterial stiffness is a good marker early disease, which also has prognostic value. It can be determined in simple, non-invasive and reproducible way through the pulse wave velocity (PWV), measure that been proved to useful stratification cardiovascular risk (CVR). <h3>Objectives</h3> To determine by studying PWV patients with rheumatoid arthritis (RA), estimate its utility CVR these patients. <h3>Methods</h3> 134 RA were assessed over period one year,...
<h3>Background</h3> Recently, a Spanish group[i] has proposed an algorithm that improves mSCORE estimation of cardiovascular risk (CVR) in patients with rheumatoid arthritis (RA), by adding the findings on carotid ultrasound (US). <h3>Objectives</h3> To estimate CV our RA combining and US (intima-media thickness [IMT] and/or atherosclerotic plaques). <h3>Methods</h3> A set 188 were assessed over period one year. Gender, age, duration RA, extra-articular disease, smoking habit, blood pressure...
<h3>Background</h3> Rheumatoid arthritis (RA) is an autoimmune pathology associated with increased risk of cardiovascular (CV) disease and subclinical atherosclerosis<sup>1</sup>. Consequently, both inflammatory diseases share common molecules involved in its pathogenesis. In this sense, interleukin 17A (IL-17A) a pro-inflammatory cytokine the regulation immune responses chronic inflammation<sup>2</sup>. <h3>Objectives</h3> To evaluate potential association between different IL-17A...