A5028304167- Aquaculture Nutrition and Growth
- Aquaculture disease management and microbiota
- Genetics, Aging, and Longevity in Model Organisms
- Cancer survivorship and care
- COVID-19 and healthcare impacts
- Physiological and biochemical adaptations
- Sarcoma Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Animal Nutrition and Physiology
- Reproductive Biology and Fertility
- Neurofibromatosis and Schwannoma Cases
- Cardiac tumors and thrombi
- Cancer, Lipids, and Metabolism
- Edible Oils Quality and Analysis
- Algal biology and biofuel production
- Neuroblastoma Research and Treatments
- Microtubule and mitosis dynamics
- Spaceflight effects on biology
- Cardiac, Anesthesia and Surgical Outcomes
- Prostate Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Free Radicals and Antioxidants
- Planarian Biology and Electrostimulation
- Plant and Biological Electrophysiology Studies
- Neurobiology and Insect Physiology Research
Mount Sinai Hospital
2006-2023
Princess Margaret Cancer Centre
2019-2022
University of Toronto
2020-2022
University Health Network
2019
Lunenfeld-Tanenbaum Research Institute
2006-2017
The University of Texas at Austin
1998
University of Guelph
1989-1994
Abstract Background Fertilization restores the diploid state and begins process by which single-cell oocyte is converted into a polarized, multicellular organism. In nematode, Caenorhabditis elegans , two of earliest events following fertilization are secretion chitinous eggshell completion meiosis, in this report we demonstrate that essential for multiple developmental at one-cell stage. Results We show GLD (Germline differentiation abnormal)-1-regulated hexosamine pathway enzyme,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAutoxidation Measurements of Fatty Oils Using Barcroft-Warburg ApparatusW Johnston and Charles FreyCite this: Ind. Eng. Chem. Anal. Ed. 1941, 13, 7, 479–481Publication Date (Print):July 1, 1941Publication History Published online1 May 2002Published inissue 1 July 1941https://doi.org/10.1021/i560095a015Request reuse permissionsArticle Views40Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article...
Objective: To update the current Sarculator retroperitoneal sarcoma (RPS) prognostic nomograms considering improvement in patient prognosis and case volume effect. Summary Background Data: Survival of patients with primary RPS has been increasing over time, volume-outcome relationship well recognized. Nevertheless, specific impact on is unknown. Methods: All consecutive adult localized treated at 8 European North American reference centers between 2010 2017 were included. Patients divided...
Abstract Polo like kinase 4 (Plk4) is a tightly regulated serine threonine that governs centriole duplication. Increased Plk4 expression, which feature of many common human cancers, causes overduplication, mitotic irregularities, and chromosomal instability. can also promote cancer invasion metastasis through regulation the actin cytoskeleton. Herein we demonstrate physical interaction with FAM46C/TENT5C, conserved protein unknown function until recently. FAM46C localizes to centrioles,...
Patients with newly diagnosed non-metastatic prostate adenocarcinoma are typically classified as at low, intermediate, or high risk of disease progression using blood prostate-specific antigen concentration, tumour T category, and pathological Gleason score. Classification is used to both predict clinical outcome inform initial management. However, significant heterogeneity observed in outcome, particularly within the intermediate group, there an urgent need for additional markers more...
Objective: The Transatlantic Australasian Retroperitoneal Sarcoma Working Group conducted a retrospective study on the disease course and clinical management of ganglioneuromas. Background: Ganglioneuromas are rare tumors derived from neural crest cells. Data these remain limited to case reports single-institution series. Methods: Patients all ages with pathologically confirmed primary retroperitoneal, intra-abdominal, pelvic ganglioneuromas between January 1, 2000, 2020, were included. We...
Voltage-gated Na+ channels generate the depolarizing inward current that is critical for initiation and conduction of action potentials. To study roles in neuronal signaling, we have begun molecular analysis Aplysia californica. We isolated cDNAs encode a channel α-subunit, which named SCAP1. DNA sequence SCAP1 cDNA revealed an open reading frame predicts protein 1,993 amino acids, highly similar to other members α-subunit gene family. RNase protection assays carried out on various tissues...
Glycoproteins such as growth factor receptors and extracellular matrix have well-known functions in development cancer progression, however, the glycans at sites of modification are often heterogeneous molecular populations which makes their functional characterization challenging. Here we provide evidence for a specific, discrete, well-defined glycan regulation stage-specific cell migration Caenorhabditis elegans. We show that chain-terminating, putative null mutation gene encoding...
In addition to DNA, gametes contribute epigenetic information in the form of histones and non-coding RNA. Epigenetic programs often respond stressful environmental conditions provide a heritable history ancestral stress that allows for adaptation propagation species. nematode C. elegans, defective transmission manifests as progressive germline mortality. We previously isolated sup-46 screen suppressors hexosamine pathway gene mutant, gna-2(qa705). this study, we examine role SUP-46...
Abstract Introduction: A marked shift in ambulatory patient assessment was instituted by cancer centers response to the COVID-19 crisis. At our center, non-urgent appointments were deferred, and essential assessments conducted virtually whenever possible. Prior COVID-19, all patients attending clinic completed an Edmonton Symptom Assessment Scale (ESAS) form via touch pad, with assistance as needed volunteers. Our purpose here explore how virtual conduct of clinics impacted collection...
e24091 Background: Prior to the COVID-19 pandemic, all patients attending ambulatory clinic at cancer centers in Ontario, Canada completed Edmonton Symptom Assessment Scale (ESAS), as per governmental agency mandate. At our center, completion was via touch pad, with assistance by volunteers. As of mid-March 2020, appointments were conducted virtually whenever possible, and pads removed from clinic. Our purpose here explore how these changes impacted collection patient-reported outcomes,...
Abstract Prior to the COVID-19 pandemic, patients attending ambulatory clinics at cancer centers in Ontario completed Edmonton Symptom Assessment Scale (ESAS) each visit. At our center, completion was via touch pad, with assistance by clinic volunteers. As of March 2020, appointments were conducted virtually when possible and pads removed. We anticipated a negative impact on collection patient-reported outcomes (PROs), recognition severe symptoms. Methods: performed prospective...