A5024585490- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Glioma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Economic and Financial Impacts of Cancer
- Caveolin-1 and cellular processes
- Immune cells in cancer
- RNA modifications and cancer
- Brain Metastases and Treatment
- Family Support in Illness
- Cancer Cells and Metastasis
- Signaling Pathways in Disease
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Advances in Oncology and Radiotherapy
- Cancer Mechanisms and Therapy
- Health Systems, Economic Evaluations, Quality of Life
- Identity, Memory, and Therapy
- Radiomics and Machine Learning in Medical Imaging
- Renal cell carcinoma treatment
- Lung Cancer Research Studies
- Nanoplatforms for cancer theranostics
- Adolescent and Pediatric Healthcare
- Radiopharmaceutical Chemistry and Applications
University of Toronto
2022-2025
Princess Margaret Cancer Centre
2023-2025
University Health Network
2024
Ontario Institute for Cancer Research
2023
The Scarborough Hospital
2023
ABSTRACT Background Adolescents and young adults (AYA, 18–39) with high‐grade glioma (HGG) face unique challenges at a life stage focused on autonomy, careers, relationships, family planning. Aim This study explores their experiences to inform life‐stage appropriate support resources. Methods In this mixed‐methods study, we surveyed AYA HGG patients Princess Margaret Cancer Centre (PM) assess symptom care satisfaction. Interviews further explored illness needs. Descriptive statistics...
Adolescents and young adults (AYAs) with cancer, representing those between 15 39 years of age, face distinctive challenges balancing their life stage the physical, emotional, social impacts a cancer diagnosis. These include fertility concerns, disruptions to educational occupational pursuits, issues related body image sexual health, need for age-appropriate psychosocial support within communities. The Princess Margaret Cancer Centre (PM), quaternary care center, established specialized AYA...
Abstract Glioblastoma (GBM) is a fatal brain cancer in adults with ineffective treatment methods. Cell adhesion molecules (CAMs) are proteins that expressed on the surface of cells and enable them to interact one another surrounding microenvironment. Intracellular molecule 1 (ICAM-1) cell by various types. Preliminary data showed ICAM-1 associated poorer overall progression free survival patients expression levels increase recurrent tumors. TAMs enhance GBM tumor growth. The aim this study...
Abstract Background Primary central nervous system (CNS) tumors significantly affect individuals globally, with patients in Ontario, Canada, often bearing financial burdens for treatments such as oral chemotherapy due to insufficient coverage, resulting complex insurance processes or out-of-pocket payments. However, limited understanding exists regarding other direct and indirect implications of their diagnosis. This study examines the strains, unmet needs, overarching challenges encountered...
Abstract Gliobastoma (GBM) is a highly aggressive solid tumor of the brain, characterized by hypoxic microevironment (TME) leading to histopathological features necrosis, microvascular proliferation and deregulated hypervascularization. The heterogeneous nature GBM results in gradient intra-tumoral hypoxia that causes molecular changes specific cell populations within bulk tumor. Our study first clinical utilize exogenous oxygen-independent marker pimonidazole (PIMO) identify TME using...
Abstract Glioblastoma (GBM) is a fatal adult CNS tumor, with median overall survival of 12-15 months. Intercellular adhesion molecule 1 (ICAM-1) cell whose expression significantly greater in the mesenchymal transcriptional subtype GBMs, whereby it prognostic. We have previously shown that when ICAM-1 knocked out tumor microenvironment (TME) immune-competent GBM-bearing mice, these mice showed prolonged and reduced volume. It yet to be determined how affects infiltration functional...
Abstract Rapidly growing solid tumors such as glioblastoma (GBM) are characteristically hypoxic, displaying large areas of necrosis surrounded by hyperproliferative pseudopalisading cells. Intra-tumoral hypoxia develops over time in the three-dimensional space and degree tissue oxygenation is a dynamic process that varies continuously. Combined with extensive inter- intra-tumoral heterogeneity associated GBM at bulk single cell level, contributes to gradient molecular alterations specific...
Abstract OBJECTIVE/PURPOSE Ontario brain tumor patients sometimes suffer the burden of responsibility to pay for treatments like oral chemotherapy. However, less is known about other direct and indirect financial costs due their diagnosis. The purpose this study was analyze publicly-available data from GoFundMe, an online fundraising platform, explore needs patients. METHOD A qualitative descriptive design drawing on thematic analysis used GoFundMe requests support individuals diagnosed with...
Abstract Rapidly growing solid tumors such as glioblastoma (GBM) are characteristically hypoxic, displaying large areas of necrosis surrounded by hyperproliferative pseudopalisading cells. Intra-tumoral hypoxia develops over time in the three-dimensional space and degree tissue oxygenation is a dynamic process that varies continuously. Combined with extensive inter- intra-tumoral heterogeneity associated GBM at bulk single cell level, contributes to gradient molecular alterations specific...
Abstract Brain tumors affect individuals globally including Ontario residents. Numerous brain tumor patients suffer the unequal burden of responsibility to pay for treatments like oral chemotherapy. In addition chemotherapy, and their families have other costs associated with diagnosis. However, less is known about direct indirect financial due GoFundMe, an online fundraising platform, provides worldwide opportunity raise money assistance diagnosis The purpose this study was analyze...
Abstract High-grade gliomas are highly aggressive and fatal primary malignant brain tumors in adults with ineffective existing treatment methods. Older greatly impacted by high-grade as they more common among this population. Young (individuals aged 18-39) uniquely glioma. However, there few resources information available to address these unique needs. The purpose of study is explore the lived experience population inform development help their specific A qualitative descriptive design...
Abstract Hypoxia is a prominent characteristic of aggressive tumors, including glioblastoma (GB), and linked to therapy resistance. Understanding the molecular mechanisms underlying hypoxia-induced changes in neoplastic non-neoplastic cells crucial for developing targeted therapies. In this study, we took comprehensive approach investigate genomic, epigenomic, spatial transcriptomic profiles intra-tumoral hypoxia GB at bulk single-cell levels. Our objectives were identify GB-specific gene...
Abstract Glioblastoma (GBM) is a deadly brain cancer in adults with limited treatment options. Cell adhesion molecules (CAMs) mediate cell-cell interactions and migration. Intercellular molecule 1 (ICAM-1) CAM expressed by various cell types solid tumors, including macrophages, tumor endothelial cells. We previously demonstrated that ICAM-1 expression linked to shorter overall survival GBM patients. observed elevated levels hypoxic regions of GBMs. Considering the role tumor-associated...
Abstract Glioblastoma (GBM) is a fatal adult solid tumour with median overall survival of 18-20 months post-diagnosis; contributing factors to therapeutic inefficacy include acquisition genomic alterations post-therapy, immune evasion, deregulated hypervascularization, and tumor microenvironmental such as hypoxia. Combined extensive inter- intra-tumoral heterogeneity at bulk single-cell level, hypoxia contributes gradient molecular that are specific different cell populations make up reside...
Abstract BACKGROUND Glioblastoma (GBM) is an aggressive and highly fatal brain cancer in adults. Existing treatment methods are ineffective we need of new treatments that extend the overall survival improve quality-of-life. Cell adhesion molecules (CAMs) proteins enable cells to communicate with one another surrounding environment. Intracellular molecule 1 (ICAM1) a CAM expressed by TAMs GBM. Tumour associated macrophages (TAMs) thought enhance tumour growth proliferation, particularly...
Abstract Rapidly growing solid tumors such as glioblastoma (GBM) are characteristically hypoxic, displaying large areas of necrosis surrounded by hyperproliferative pseudopalisading cells. Intra-tumoral hypoxia develops over time in the three-dimensional space and degree tissue oxygenation is a dynamic process that varies continuously. Combined with extensive inter- intra-tumoral heterogeneity associated GBM at bulk single cell level, contributes to gradient molecular alterations specific...
Abstract Glioblastoma (GBM) is a fatal brain cancer in adults with ineffective existing treatment methods. Cell adhesion molecules (CAMs) are proteins that expressed on the surface of cells and enable them to interact one another surrounding microenvironment. Intracellular molecule 1 (ICAM-1) cell by macrophages, tumor endothelial GBM. Preliminary data showed ICAM-1 associated poorer overall progression free survival GBM patients expression levels increase recurrent tumors. TAMs enhance...