A5044120998- Visual perception and processing mechanisms
- Neural and Behavioral Psychology Studies
- Dementia and Cognitive Impairment Research
- Memory and Neural Mechanisms
- Older Adults Driving Studies
- Neural dynamics and brain function
- Spatial Neglect and Hemispheric Dysfunction
- Urban Transport and Accessibility
- Multisensory perception and integration
- Functional Brain Connectivity Studies
- Hepatitis C virus research
- Olfactory and Sensory Function Studies
- Traffic and Road Safety
- EEG and Brain-Computer Interfaces
- Memory Processes and Influences
- Neurobiology of Language and Bilingualism
- Liver Disease Diagnosis and Treatment
- Neurobiology and Insect Physiology Research
- Hepatitis B Virus Studies
- Motor Control and Adaptation
- Cognitive Functions and Memory
- Visual Attention and Saliency Detection
- Non-Invasive Vital Sign Monitoring
- Creativity in Education and Neuroscience
- Blood Pressure and Hypertension Studies
Brown University
2013-2024
John Brown University
2008-2024
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2017-2024
University of Brescia
2016-2019
University of California, San Diego
2015
VA San Diego Healthcare System
2015
<b>Objective: </b> The goal of this study was to define the natural progression driving impairment in persons who initially have very mild dementia. <b>Methods: We studied 128 older drivers, including 84 with early Alzheimer disease (AD) and 44 age-matched control subjects without cognitive impairment. Subjects underwent repeated assessments their cognitive, neurologic, visual, physical function over 3 years. Self-reports accidents traffic violations were supplemented by reports from family...
Abstract Introduction We conducted a 27‐month longitudinal study of mid‐life adults with preclinical Alzheimer's disease (AD), using spectral domain optical coherence tomography to compare changes in volume and thickness all retinal neuronal layers those age‐matched healthy control subjects. Methods Fifty‐six older (mean age = 65.36 years) multiple risk factors for AD completed imaging cognitive testing at baseline. Twenty‐seven months later, they the same examinations an 18 F‐florbetapir...
Neuropsychological and motor deficits in Parkinson's disease that may contribute to driving impairment were examined a cohort study comparing patients with (PD) Alzheimer's (AD) healthy elderly controls. Nondemented individuals [Hoehn & Yahr (H&Y) stage I-III], [Clinical Demetia Rating scale (CDR) range 0-1], controls, who actively driving, completed neuropsychological battery standardized road test administered by professional instructor. On-road ability was rated on number of errors global...
To examine the sensitivity and specificity of Assessment Driving-Related Skills (ADReS), a clinical tool recommended by American Medical Association for identifying potentially unsafe older drivers that includes tests vision, motor function, cognition. Cross-sectional observation study. Memory assessment outpatient clinic university hospital. Drivers with normal cognition (n = 47) cognitive impairment 75). A neurologist completed ADReS during an office visit. Additional executive,...
In recent years, an increasing number of individuals affected by neglected tropical diseases (NTDs) have been observed in Italy, due to migration, international travels and climate changes. Reliable data on the current NTD epidemiology Italy health system preparedness this issue are not available.We report results a survey selected NTDs (schistosomiasis, strongyloidiasis, echinococcosis, Chagas disease, leishmaniasis, cysticercosis, filariasis scabies) nine Italian sentinel centres, order...
This study examined the ability of computerized maze test performance to predict road cognitively impaired and normal older drivers. The authors 133 drivers, including 65 with probable Alzheimer disease, 23 possible 45 control subjects without cognitive impairment. Subjects completed 5 tasks employing a touch screen pointer as well battery standard neuropsychological tests. Parameters measured for mazes included errors, planning time, drawing total time. Within 2 weeks, were by professional...
Objectives To relate the standardized road test to video recordings of naturalistic driving in older adults with a range cognitive impairment. Design Cross‐sectional observational study. Setting Academic medical center memory disorders clinic. Participants One hundred three drivers (44 healthy, 59 impairment) who passed test. Measurements Error rate and global ratings safety (pass without recommendations, marginal restrictions or training, fail) made by professional instructor. Results There...
The effects of aging and Alzheimer's disease (AD) on phasic alerting exogenous spatial orienting were examined within a single precuing task. Phasic decreased with normal was completely eliminated AD. AD patients also demonstrated an increased effect, attributable to benefit from that associated nonselective alerting. These results suggest performance the paradigm reflects product interaction between processes spatially selective processes. highlight importance simultaneously assessing same...
The cortical pathology in Alzheimer's disease (AD) should lead to the loss of effective interaction between distinct neocortical areas. This study compared 2 conditions within a single sensory integration task that differed demands placed on cross-cortical interaction. AD patients were impaired their ability bind visual features stimulus when this binding greater (i.e., motion and color) but not lesser such luminance). In contrast, neurologically intact individuals with Huntington's able...
Previous findings that older drivers engage in strategic self-regulatory behaviors to minimize perceived safety risks are primarily based on survey reports rather than actual behavior. This study analyzed in-car video recording of naturalistic driving 18 patients with Alzheimer disease (AD) and 20 age-matched controls order (1) characterize engaged by (2) assess how change cognitive impairment. Only participants who were rated “safe” a prior standardized road test selected for this study....
Objective: We conducted a combined observational cohort and case-control study in patients with Alzheimer disease (AD) to assess the effects of acetylcholinesterase inhibitor (ChEI) treatment on cognitive functions important for driving. Methods: Performance 24 outpatients newly diagnosed (untreated) early-stage AD was compared before beginning ChEI (pre-ChEI) after 3 months therapy (post-ChEI) set computerized tests visual attention executive function administered under both single-task...
Effective audiovisual sensory integration involves dynamic changes in functional connectivity between superior temporal sulcus and primary areas. This study examined whether disrupted early Alzheimer’s disease (AD) produces impaired under conditions requiring greater corticocortical interactions. Audiovisual speech was healthy young adult controls (YC), elderly (EC), patients with amnestic mild cognitive impairment (MCI) using McGurk-type stimuli (providing either congruent or incongruent...
<h3>Objective:</h3> Visual processing abilities of patients with dementia Lewy bodies (DLB) or Alzheimer disease (AD) were assessed psychophysically using a simple horizontal motion discrimination task that engages the dorsal visual stream. <h3>Methods:</h3> Participants included mild DLB, AD Parkinson (PD) (PDD), without PD, and normal controls. indicated left right direction coherently moving dots embedded within dynamic noise provided by randomly dots. The proportion was increased...
Analyzing naturalistic driving behavior recorded with in-car cameras is an ecologically valid method for measuring errors, but it time intensive and not easily applied on a large scale. This study validated semi-automated, computerized using archival data collected drivers mild Alzheimer’s disease (AD; n = 44) age-matched healthy controls (HC; 16). The flagged situations where safety concerns are most likely to occur (i.e., rapid stops, lane deviations, turns, intersections). These epochs...
The ability to use past experience effectively guide decision-making declines in older adulthood. Such have been theorized emerge from either impairments of striatal reinforcement learning systems (RL) or recurrent networks prefrontal and parietal cortex that support working memory (WM). Distinguishing between these hypotheses has challenging because RL WM could be used facilitate successful typical laboratory tasks. Here we investigated the neurocomputational correlates age-related deficits...
Abstract Many daily activities require performance of multiple tasks integrating cognitive and motor processes. While the fact that both processes go through deterioration changes with aging has been generally accepted, not much is known about how interacts stages skill acquisition under a cognitively demanding situation. To address this question, we combined visuomotor adaptation task secondary task. We made two primary findings beyond expected age-related deterioration. First, while young...
Situation awareness (SA) is important in many demanding tasks (e.g. driving). Assessing SA during training can indicate whether someone ready to perform the real world. typically assessed by interrupting task ask questions about situation or asking after completion, assessing only momentary SA. An objective and continuous means of detecting needed. We examined neurophysiological sensors are useful objectively measure Level 3 (projection events into future) a driving task. measured speed at...
Although many studies have examined the neural substrates underlying phasic alerting and spatial orienting, few directly interplay of these attentional systems within a single task. While some suggest that effects are additive or independent, finding non-spatial auditory cues improve orienting in neglect patients (Robertson et al., 1998) indicates an interaction between systems. A recent study our lab found cue purely exogenous peripheral cueing task selectively reduced RTs to validly cued...
Abstract Objectives: Patients with Alzheimer’s disease (AD) demonstrate deficits in cross-cortical feature binding distinct from age-related changes selective attention. This may have consequences for driving performance given its demands on multisensory integration. We examined the relationship of visuospatial search and to patients early AD elderly controls (EC). Methods: Participants (42 AD; 37 EC) completed tasks requiring either luminance-motion (L-M) or color-motion (C-M) binding,...
Abstract The present study assessed frontostriatal mediated memory functions in children with ADHD (N = 12) and healthy control participants using two tests of conditional associative learning (i.e., object spatial) that shared similar stimulus-response association structures but differed terms the demands placed upon strategic processes. Children displayed normal performance on task were impaired spatial greater internally derived Secondary analyses further indicated this processing...