A5055400348- SARS-CoV-2 and COVID-19 Research
- HER2/EGFR in Cancer Research
- BRCA gene mutations in cancer
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Cancer Risks and Factors
- Molecular Biology Techniques and Applications
- Epigenetics and DNA Methylation
- COVID-19 Clinical Research Studies
- Pregnancy and preeclampsia studies
- Skin and Cellular Biology Research
- Breast Cancer Treatment Studies
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- CRISPR and Genetic Engineering
- Cancer, Hypoxia, and Metabolism
- Tannin, Tannase and Anticancer Activities
- Genomic variations and chromosomal abnormalities
- Vaccine Coverage and Hesitancy
- Viral-associated cancers and disorders
- RNA Interference and Gene Delivery
- Genetics, Bioinformatics, and Biomedical Research
- Gene expression and cancer classification
- Cancer, Stress, Anesthesia, and Immune Response
Universitas Gadjah Mada
2016-2025
Centre International de Recherche sur le Cancer
2016
ADA University
2007
Specific mutations in BRCA1 and BRCA2 genes have been identified specific populations ethnic groups. However, little is known about the contribution of to breast cancers Indonesian population. One hundred-twenty moderate high risk cancer patients were tested using PCR-DGGE, any aberrant band was sequenced. Multiplex ligation-dependent probe amplification (MLPA) performed on all samples detect large deletions two genes. Twenty-three different detected 30 individuals, ten deleterious 20...
Several types of vaccines have been developed to prevent the coronavirus disease 2019 (COVID-19). It is important understand whether demographic and clinical variables affect effectiveness various vaccines. This study analysed association between demographic/clinical factors, antibody response vaccine in healthcare workers vaccinated with inactivated virus. We enrolled 101 who received two doses viral (CoronaVac). Blood samples were at 1, 3, 5 months after second dose vaccination. Data...
To examine the diversity of somatic alterations and clonal evolution according to aggressiveness disease, nineteen tumor-blood pairs 'formerly bronchiolo-alveolar carcinoma (BAC)' which had been reclassified into preinvasive lesion (adenocarcinoma in situ; AIS), focal invasive (minimally adenocarcinoma; MIA) (lepidic predominant LPA non-lepidic non-LPA) IASLC/ATS/ERS 2011 classification were explored by whole exome sequencing. Several distinct observed compare lung adenocarcinoma study from...
Objective: Breast carcinoma is a heterogeneous disease which rich in diversity. Molecular subtypes of breast cancer, histological grade and lymph node metastases are strong prognostic predictive factors. In Indonesia, only limited number studies have investigated the correlation between molecular with metastases. Methods: We analyzed 247 invasive cases from Anatomic Pathology Installation Dr. Sardjito General Hospital Yogyakarta 2012-2015. The slides were stained for estrogen receptors (ER),...
The incidence of the Coronavirus Disease 2019 (COVID-19) among healthcare workers (HCWs) is widespread. It important to understand COVID-19 characteristics HCWs before and after vaccination. We evaluated in East Java, Indonesia comparing disease between pre- vs post-vaccination periods.A retrospective observational study was conducted two major hospitals Indonesia, April 01, 2020, Oct 31, 2021. All were offered vaccination with inactivated viral vaccine (CoronaVac) from Jan 15, Therefore, we...
Chalcone-3 has been shown to be cytotoxic and selective against luminal subtype breast cancer cell lines, which are suspected occur through the mechanism of epidermal growth factor receptors (EGFR) inhibition. However, effect never tested on strains from patients with triple negative (TNBC), where EGFR expression is known increase. This study aimed identify role chalcone-3 in one downstream targets as an antiproliferative agent.Chalcone-3 was examined for its proliferation human MDA-MB-231...
The journal of APJCP (Asian Pacific Journal Cancer Prevention) focuses to gather relevant and up-to-date novel information's related cancer sciences. research methodologies approaches adopted by the researcher are prone variation which may be desirable in context scientific findings however, reproducibility for these studies needs unified assured. issues highly concerned when preclinical reported cancer, natural products particular. medicinal plants a wide terms phytochemistry...
The HER-2/neu transmembrane tyrosine kinase receptor is both a prognostic marker and therapeutic target for breast cancer. Accurate determination of status prerequisite selecting tumors immunotherapy or taxan based chemotherapy. Unfortunately, there no consensus concerning how this should be reached. We compared assessment using Multiplex ligation-dependent probe amplification (MLPA) immunohistochemistry (IHC). patient group comprised 60 Indonesian cancers patients. IHC was performed on...
Objective: Breast carcinoma (BC) is a heterogeneous disease that exhibits variation in biological behaviour, prognosis and response to therapy. Molecular classification generally into Luminal A, B, HER2+ triple negative/basal-like, depending on receptor characteristics. Clinical factors determined the BC are age tumor size. Since information molecular subtypes of Indonesian BCs limited, present study was conducted, with attention relation Methods: A retrospective cross-sectional 247...
Objective: Dietary high fibre and calcium intake has been suggested to reduce colorectal cancer risk. However, there is limited information available regarding the potential of edible canna (Ganyong), with dietary content, act as a preventive agent for cancer. This experimental study was conducted investigate effect Ganyong in reducing carcinogenesis attention effects on adenomatous polyposis coli (APC) inducible nitric oxide synthase (iNOS) expression. Methods: Thirty male Wistar rats were...
Background: The administration of the third (or booster) dose COVID-19 vaccine is important in maintaining protection against SARS-CoV-2 infection or severity disease. In Indonesia, health care workers (HCWs) are among first to receive a booster vaccine. this study, we evaluated antibody response and adverse events following heterologous using mRNA-1273 HCWs that were fully vaccinated with inactivated viral as priming doses. Methods: 75 at Dr. Soetomo General Hospital Surabaya, participated...
Epidermolysis bullosa (EB) is a group of inherited blistering skin diseases known to have heterogenicity phenotypes and genotypes. There are four main types EB: simplex, junctional, dystrophic, Kindler syndrome, which further classified into 34 distinct subtypes. Twenty different gene mutations responsible for the loss function integrity basal membrane zone. In limited-resource settings such as Indonesia, diagnoses hereditary disease often rely on clinical features. This limitation was...
Background: Breast cancer is increasing in Indonesia and other developing countries. Germline mutations the BRCA1/2 genes are most strongly associated with a high risk for breast development. There have been no reports on gene Indonesian population. Genetic research yielding insight into affecting population can help assessment of individual patients. Aims: To screen early onset patients their families new, simple, sensitive mutation screening strategy based denaturing gradient gel...
Several types of vaccines have been developed to prevent the coronavirus disease 2019 (COVID-19). It is important understand whether demographic and clinical variables affect effectiveness various vaccines. This study analysed association between demographic/clinical factors, antibody response vaccine in healthcare workers vaccinated with inactivated virus.We enrolled 101 who received two doses viral (CoronaVac). Blood samples were at 1, 3, 5 months after second dose vaccination. Data...
A1 Hope and despair in the current treatment of nasopharyngeal cancer IB Tan I1 NPC international incidence risk factors Ellen T Chang I2 Familial carcinoma use biomarkers Chien-Jen Chen, Wan-Lun Hsu, Yin-Chu Chien I3 Genetic susceptibility for sporadic familial NPC: recent findings Allan Hildesheim I5 environmental Southeast Asia James D McKay, Valerie Gaborieau, Mohamed Arifin Bin Kaderi, Dewajani Purnomosari, Catherine Voegele, Florence LeCalvez-Kelm, Graham Byrnes, Paul Brennan, Beena...
Objectives: Breast cancer tend to be more progressive with poorer prognosis in younger patients than those at an older age. Single Nucleotide Polymorphisms (SNPs) of P53 Pro72Arg, MDM2 SNP309, P21 Ser31Arg, ER SNP594, HER2 Ile655Val, and FGFR2 rs2981582 have drawn attention as genetic factors associated risk. However, there were contradictory results involving different races their association is still unknown Indonesian populations. This study was performed examine the proportion these six...
In the current pandemic, highly contagious nature of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) leads to an enormous burden for global health care system and creates challenging socioeconomic problems. Respiratory mucosa, main entrance SARS-CoV-2 infection, are equipped with innate immune defense as initial response against infection. Activation adaptive facilitates viral clearance well providing immunological memory prevention from subsequent exposure. However,...