A5076043851- Viral-associated cancers and disorders
- Parvovirus B19 Infection Studies
- Respiratory viral infections research
- Hepatitis C virus research
- Cytomegalovirus and herpesvirus research
- Lymphoma Diagnosis and Treatment
- Polyomavirus and related diseases
- Head and Neck Cancer Studies
- Hepatitis B Virus Studies
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Biochemical Analysis and Sensing Techniques
- Viral Infections and Immunology Research
- Glutathione Transferases and Polymorphisms
- Carcinogens and Genotoxicity Assessment
- RNA modifications and cancer
- Animal Virus Infections Studies
- Hepatitis Viruses Studies and Epidemiology
- Tea Polyphenols and Effects
- Epigenetics and DNA Methylation
- T-cell and Retrovirus Studies
- Zeolite Catalysis and Synthesis
- COVID-19 and Mental Health
- Nutrition, Health and Food Behavior
- Effects of Radiation Exposure
Genomics Research Center, Academia Sinica
2009-2023
National Health Research Institutes
2018-2023
China Medical University
2012
China Medical University Hospital
2012
Ministry of Health and Welfare
2004
National Cheng Kung University
2000
Abstract This study aimed to assess independent effects of EBV and cigarette smoking on nasopharyngeal carcinoma, which have never been assessed in long-term follow-up studies. A cohort 9,622 men was enrolled from 1984 1986. Blood samples collected at entry were tested for antibodies against antigens (anti-EBV) viral capsid antigen immunoglobulin DNase. The habit inquired through questionnaire interview. Newly developed carcinoma cases ascertained computerized linkage with national cancer...
Background Epstein-Barr virus (EBV) is necessary for the development of nasopharyngeal carcinoma (NPC). By adulthood, approximately 90% individuals test EBV-positive, but only a fraction develop cancer. Factors that identify which are most likely to disease, including differential antibody response virus, could facilitate detection at early stages when treatment effective.Methods We measured anti-EBV IgG and IgA responses in 607 Taiwanese individuals. Antibodies were using custom protein...
Two Epstein-Barr virus (EBV)-based testing approaches have shown promise for early detection of nasopharyngeal carcinoma (NPC). Neither has been independently validated nor their performance compared. We compared diagnostic in an independent population.
Background The association between human leukocyte antigen (HLA) genes (located in the Major Histocompatibility Complex [MHC] region of chromosome 6p21) and NPC has been known for some time. Recently, two genome-wide studies (GWAS) conducted Taiwan China confirmed that strongest evidence was mapped to MHC region. It is still unclear, however, whether these findings reflect direct associations with Human Leukocyte Antigen and/or other this gene-rich Methods To better understand genetic within...
Background A case-control study was conducted to evaluate the role of adult diet on nasopharyngeal carcinoma (NPC) in Taiwan. Methods total 375 incident NPC cases and 327 controls matched sex, age, residence were recruited between July 1991 December 1994. structured questionnaire inquiring complete dietary history, socio-demographic characteristics, other potential confounding factors used personal interview. Unconditional logistic regression analysis estimate multivariate-adjusted odds...
Serological testing for nasopharyngeal carcinoma (NPC) has recently been reinvigorated by the implementation of novel Epstein-Barr virus (EBV)-specific IgA and IgG antibodies from a proteome array. Although arrays are well suited comprehensive antigen selection, they not applicable large-scale studies. We adapted 13-marker EBV signature NPC risk identified to multiplex serology establish an assay Taiwanese cases (n = 175) matched controls were used validation. Spearman's correlation was...
Little is known about variation in antibody responses targeting the full spectrum of Epstein-Barr virus (EBV) proteins and how such patterns inform disease risk.We used a microarray to measure immunoglobulin G (IgG) A (IgA) against 199 EBV protein sequences from 5 strains recovered 289 healthy adults Taiwan. We described positivity patterns, estimated correlation between antibodies, investigated associations environmental genetic risk factors variations responses.Healthy were more likely...
Epstein-Barr virus (EBV) is linked to multiple cancers, including classical Hodgkin lymphoma (cHL), endemic Burkitt (eBL), nasopharyngeal carcinoma (NPC), and extranodal natural killer/T-cell (NKTCL).
Evidence on the association between dietary component, pattern and nasopharyngeal carcinoma (NPC) is scarce. A major challenge high degree of correlation among constituents. We aimed to identify associated with NPC illustrate dose-response relationship identified scores risk NPC. Taking advantage a matched case–control study, data from total 319 incident cases controls were analyzed. Dietary was derived employing partial least square discriminant analysis (PLS-DA) performed energy-adjusted...
We previously reported that higher levels of antibody targeting Epstein-Barr virus (EBV) glycoprotein350 (gp350), an EBV vaccine candidate, were protective against nasopharyngeal carcinoma (NPC) in genetically high-risk families from Taiwan. The current study attempted to extend this association a general population cohort.We compared total and IgA-specific gp350 35 incident NPC cases 81 disease-free controls the Cancer Screening Program Taiwan (23943 individuals recruited 1991-1992)....
There are striking ethnic and geographical variations in risk of nasopharyngeal carcinoma (NPC). Males have a higher NPC than females all populations, high populations younger peak age at onset low populations. Epstein-Barr virus infection has been consistently documented to be associated with an increased NPC. Dietary factors, especially Cantonese salted fish preserved foods, important factors for Cigarette smoking, occupational exposures wood dust, formaldehyde chemical fumes, use Chinese...
Genetic susceptibility is associated with nasopharyngeal carcinoma (NPC). We previously identified rare variants potentially involved in familial NPC and common significantly sporadic NPC.We conducted targeted gene sequencing of 20 genes [16 from the study multiplex families, three a pooled analysis genome-wide association (GWAS), one both studies] among 819 cases 938 controls two case-control studies Taiwan (independent previous studies). A targeted, PCR primer panel was designed using...
Taiwan is an endemic area of hepatitis B virus (HBV) infection. More than 90% the general population has been infected with HBV, and prevalence chronic infection as high 15% to 20%. Liver cancer first leading neoplasm for men third women. Its age-adjusted incidence per 100,000 was 48 18 women in 2000. Malignant cause death, liver death Deaths from cirrhosis diseases also ranked sixth death. Several early clinical trials on efficacy immunoglobulin HBV vaccine children were carried out our...
A1 Hope and despair in the current treatment of nasopharyngeal cancer IB Tan I1 NPC international incidence risk factors Ellen T Chang I2 Familial carcinoma use biomarkers Chien-Jen Chen, Wan-Lun Hsu, Yin-Chu Chien I3 Genetic susceptibility for sporadic familial NPC: recent findings Allan Hildesheim I5 environmental Southeast Asia James D McKay, Valerie Gaborieau, Mohamed Arifin Bin Kaderi, Dewajani Purnomosari, Catherine Voegele, Florence LeCalvez-Kelm, Graham Byrnes, Paul Brennan, Beena...
<div>AbstractBackground:<p>Epstein–Barr virus (EBV) is linked to multiple cancers, including classical Hodgkin lymphoma (cHL), endemic Burkitt (eBL), nasopharyngeal carcinoma (NPC), and extranodal natural killer/T-cell (NKTCL).</p>Methods:<p>Anti-EBV IgG IgA antibody responses targeting 202 sequences from 86 EBV proteins were measured using the same whole proteome array across four case–control studies investigating EBV-positive cHL, eBL, NPC, NKTCL (407 cases/620...
This study aims to investigate the prevalence of isolated core antibodies against hepatitis B (IAHBc) in different birth cohorts using a large medical record database. Hepatitis viral serological test data were collected from chart cloud database at center Taiwan between January 2006 and December 2018. The included year, sex, markers (HBsAg, anti-HBs or anti-HBc), vaccination records. Enrolled patients grouped according their year into three categories: ≤ 1986, 1987-1992, ≥ 1993, which...
To determine the required hepatitis B vaccine doses for subjects who were seronegative three seromarkers during their youth wish to have seroprotective antibodies against surface antigen (anti-HBs).We conducted a retrospective cohort study. From 2012 2015, graduate school students born after 1986 virus at college entrance (n = 1037) recruited. Four groups of received zero booster free willingness, and anti-HBs titre measured entrance. Very low extremely antibody titres elucidated by graphic...
<p>Supplemental Figure 3</p>
<p>Coefficient of variation by study and antibody.</p>