The objectives of this study were to develop stable cyclosporine A (CsA) ophthalmic micelle solutions for dry-eye syndrome and evaluate their physicochemical properties therapeutic efficacy.CsA-micelle (MS-CsA) created by a simple method with Cremophor EL, ethanol, phosphate buffer. We investigated the particle size, pH, osmolarity. In addition, long-term physical chemical stability MS-CsA was observed. To confirm efficacy, tear production in dry eye-induced rabbits evaluated using Schirmer...

To investigate white matter abnormalities in patients with obsessive–compulsive disorder and to clarify the relationship between discrete alterations symptom dimensions, fractional anisotropy obtained from 25 male matched normal controls were analyzed. The had a significantly lower left anterior cingulate than controls. When stratified by clinical predominant aggressive/checking dimension exhibited matter, whereas contamination/cleaning showed higher bilateral prefrontal matter. Our findings...

Febrile seizure (FS) is one of the most common neurological manifestations coronavirus disease-2019 (COVID-19) in children. We compared clinical characteristics FS patients with and without COVID-19 during pandemic period.This retrospective single-center study included aged 0-18 years who visited pediatric emergency department (ED) from January 1, 2022, to April 30, 2022.A total 186 ED period: 123 (66.1%) were positive for 63 (33.9%) negative. Patients predominantly male (70.7% vs. 50.8%, p...

Objectives: The purpose of this study was to observe the pharmacokinetic behavior newly synthesized biocompatible polymers based on polyhydroxyethylaspartamide (PHEA) be used coat an iron oxide core make superparamagnetic nanoparticles (SPION). Materials and methods: isotopes [ 14 C] 59 Fe] were label polymer backbone (CLS) (FLS), respectively. In addition, unradiolabeled cold (SPION/ULS) characterize particle size by dynamic light scattering, morphology transmission electron microscopy, in...

Abstract Background Intussusception decreases blood flow to the bowel, and tissue hypoperfusion results in increased lactic acid levels. We aimed determine whether levels are associated with pediatric intussusception outcomes. Methods The electronic medical records of our emergency department patients diagnosed intussusception, between January 2015 October 2018, were reviewed. An outcome was considered poor when recurred within 48 h reduction or surgical required due air enema failure....

Pediatric patients undergoing diagnostic tests in the pediatric emergency room are frequently sedated. Although efforts made to prevent adverse events, no sedation protocol has specified optimal regimen, dosage, and interval of medication events. This study analyzed safety efficacy sequential protocols for a single tertiary medical center. The records aged < 18 years who visited Seoul Asan Medical Center between January December 2019 testing were retrospectively reviewed. Sedation consisted...

Testicular torsion (TT) is a pediatric surgical emergency that requires prompt treatment. This study investigated the feasibility of point-of-care ultrasound (POCUS) for diagnosing TT in department (ED).We retrospectively reviewed medical records patients, aged 18 years or younger, who visited university-affiliated hospital ED with acute scrotal pain without trauma history and underwent diagnostic ultrasounds between January 2010 October 2022.This included 731 patients (median age: 9 years),...

(1) Background: Metallic materials are predominantly used for spinal implants, and they can damage adjacent bones intervertebral discs (IVDs) owing to their high elastic moduli. Consequently, there is a possibility that serious complications, such as kyphosis, may occur the sequelae progresses. In this study, behavior of lumbar spine implant system was evaluated using finite element (FE) method, by applying porous structure implants resolve problem metal implants. (2) Methods: An FE model...

This study aimed to investigate the feasibility of point-of-care ultrasound (POCUS) for diagnosing hypertrophic pyloric stenosis (HPS) in emergency department (ED).A retrospective was conducted infants aged younger than 90 days who were brought ED due vomiting between January 2015 and December 2019. Of these, clinically suspected having HPS underwent included categorized into 3 groups: POCUS only, followed by radiologist-performed (RADUS), RADUS only. All confirmative diagnoses made RADUS....

Coronavirus disease 2019 (COVID-19) changed the epidemiology of various diseases. The present study retrospectively investigates epidemiologic and clinical changes in pediatric intussusception for ages ≤ 7 years before (February 2019-January 2020) after 2020-January 2021) COVID-19 outbreak a single emergency department university-affiliated tertiary hospital. incidence communicable diseases-defined as infectious diseases with potential human-to-human transmission via all methods,...

Abstract Ulmus davidiana Planch (Ulmaceae) (UD) has long been known to be antiinflammatory in traditional Korean medicine. This experiment investigated the effects of UD on bone resorption using cell culture. Different concentrations crude extract were added mouse The mitochondrial activity cells after exposure was determined by colorimetric 3‐(4,5‐dimethylthiazolyl‐2)‐2,5‐diphenyltetrazolium bromide (MTT). It demonstrated that potential culture without cytotoxicity. most effective...

Fever in infants under 90 days of age is highly likely to be caused by a severe bacterial infection (SBI) and it accounts for large number patients visiting the pediatric emergency room. In order predict reduce unnecessary treatment, classic classification system based on white blood cell (WBC) count, urinalysis, x-ray, modified applied at each center incorporating recently studied biomarkers such as c-reactive protein (CRP) or procalcitonin (PCT). This study analyzed usefulness PCT...

In the present study two different formulations containing 50 mg itopride HCl (N-[4-[2-(dimethylamino)ethoxy]benzyl]-3,4-dimethoxybenzamide HCl, CAS 122898-67-3) were compared in 28 healthy male volunteers order to compare bioavailability and prove bioequivalence. The was performed an open, single dose randomized, 2-sequence, crossover design with a one-week washout period. Blood samples for pharmacokinetic profiling drawn at selected times during 24 h. serum concentrations of determined...

Background: Over 400 genes contribute to the development of congenital heart disease (CHD). Additionally, multisystemic manifestations accompanying syndromic CHD pose a higher risk genetic diseases. This study investigated diagnostic yield whole-exome sequencing (WES) in patients with sporadic and phenotypic factors affecting rate. Methods: Sixty-four aged 0.05), between groups without variant. However, ≥3 extracardiac phenotypes had significantly likelihood having variant than those ≤2...

Purpose: This study was performed to analyze clinical features and use of renal replacement therapy (RRT) for children who visit the pediatric emergency department with benign acute childhood myositis (BACM) or rhabdomyolysis.Methods: We retrospectively reviewed medical records 289 visited BACM rhabdomyolysis from January 2013 through December 2022. Clinical features, laboratory microbiological findings, outcomes were compared between two diagnoses. Subsequently, multivariable logistic...

Abstract Background Recent reports have demonstrated promising results regarding the use of ketamine sedation for reducing pediatric intussusception without an associated elevated risk bowel perforation. However, data on direct intraluminal pressure are still lacking. This study aimed to investigate safety, primarily by comparing pressure. Methods retrospective included patients aged 10 years or younger, diagnosed with at a university‐affiliated emergency department (ED) between July 2021...

Objectives: This study aimed to develop machine learning (ML) prediction models for identifying bloodstream infection (BSI) and septic shock (SS) in pediatric patients with cancer who presenting febrile neutropenia (FN) at emergency department (ED) visit. Materials Methods: A retrospective was conducted on patients, aged younger than 18 years, visited a tertiary university-affiliated hospital ED due FN between January 2004 August 2022. ML models, based XGBoost, were developed BSI SS...

Background This study analyzed national data on serious pediatric trauma cases presenting at emergency departments in Korea. Methods We from the National Emergency Department Information System of The inclusion criteria for dataset included: age under 20 years, a Korean Triage Acuity (KTAS) level 1 or 2, visit to department due trauma, and years 2016 2020 during which KTAS was systematically recorded. Results A total 10,680 patients (2,136/year) were included (KTAS levels 2: 13.1% 86.9%,...

This study compared the emergency department (ED) flow of young infants under 90 days old presenting with gastrointestinal symptoms who underwent point-of-care ultrasound (POCUS) versus X-ray (XR) as their primary imaging test. The retrospectively enrolled (GI) visited a tertiary university-affiliated hospital ED from January 2019 to September 2022. patients were divided into 2 groups based on whether they received XR or POCUS first Out 440 patients, 352 (80%) in XR-first group and 88 (20%)...