A5015153513- Analytical Methods in Pharmaceuticals
- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Metabolomics and Mass Spectrometry Studies
- Nanoparticle-Based Drug Delivery
- Inflammatory mediators and NSAID effects
- Antiplatelet Therapy and Cardiovascular Diseases
- Cyclone Separators and Fluid Dynamics
- Eicosanoids and Hypertension Pharmacology
- Polyamine Metabolism and Applications
- Fungal Plant Pathogen Control
- Aerosol Filtration and Electrostatic Precipitation
- Pharmacogenetics and Drug Metabolism
- Diabetes Treatment and Management
- Analytical Chemistry and Chromatography
- Hydrogels: synthesis, properties, applications
- Characterization and Applications of Magnetic Nanoparticles
- biodegradable polymer synthesis and properties
- Advanced Polymer Synthesis and Characterization
- Ion Channels and Receptors
- Hormonal and reproductive studies
- Ginseng Biological Effects and Applications
- Pharmacological Effects and Assays
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
Korea Pharma (South Korea)
2013-2020
Pelargonium sidoides (PS) and Coptis chinensis root (CR) have traditionally been used to treat various diseases, including respiratory gastrointestinal infections, dysmenorrhea, hepatic disorders. The present study was conducted evaluate the anti-inflammatory effects of a combination PS CR in vitro vivo. + on induction inflammation-related proteins were evaluated lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. levels nitric oxide (NO) inflammatory cytokines prostaglandin E2 (PGE2)...
Objectives: The purpose of this study was to observe the pharmacokinetic behavior newly synthesized biocompatible polymers based on polyhydroxyethylaspartamide (PHEA) be used coat an iron oxide core make superparamagnetic nanoparticles (SPION). Materials and methods: isotopes [ 14 C] 59 Fe] were label polymer backbone (CLS) (FLS), respectively. In addition, unradiolabeled cold (SPION/ULS) characterize particle size by dynamic light scattering, morphology transmission electron microscopy, in...
This study examined the effects of esomeprazole on aceclofenac pharmacokinetics and gastrointestinal complications in rats. Aceclofenac alone, or combination with esomeprazole, was orally administered to male Sprague-Dawley Plasma concentrations aceclofenac, its major metabolite diclofenac, were simultaneously determined by a novel liquid chromatography-tandem mass spectrometry method. Gastrointestinal damage measuring ulcer area lesion index stomach. Oral administration induced significant...
Eperisone hydrochloride is used in the treatment of musculoskeletal disorders as a muscle relaxant via blocking calcium channels. In this study, we aimed to investigate within-subject variability (CVwR) reference eperisone formulation for highly-variable drugs and perform bioequivalence study two oral formulations (sugar- film-coated tablets) 50 mg healthy subjects by reference-replicated crossover study.36 Korean male were recruited, 33 completed study. A randomized, single-dose,...
We used a heterozygous gene deletion library of fission yeasts comprising all essential and non-essential genes for microarray screening target the antifungal terbinafine, which inhibits ergosterol synthesis via Erg1 enzyme. identified 14 strains corresponding to 10 [7 ribosomal-protein (RP) coding genes, spt7, spt20, elp2] 4 (tif302, rpl2501, rpl31, erg1). Expectedly, their erg1 mRNA protein levels had decreased compared control strain SP286. When we studied action mechanism using cognate...
This study aimed to compare the pharmacokinetic (PK) and safety profiles of 2 fenofibric acid formulations under fasting fed conditions. The reference was a 135 mg capsule, while test 110 enteric-coated tablet. randomized, open-label, two-sequence, two-period crossover phase 1 clinical trial conducted in healthy Korean men. Sixty participants were enrolled each feeding groups. Blood samples collected 72 hours after drug administration. PK parameters calculated using non-compartmental method...
PHEA (hydroxyethyl-aspartamide)-mPEG (methoy-polyethyleneglycol)- (hexadecylamine)-ED (ethylenediamine) was prepared as a drug delivery carrier. The structure and molecular weight of polymers were characterized by -NMR gel permeation chromatography. Micelle size shape measured electro-photometer light scattering transmission electron microscope. mean diameter micelles 23 nm in aqueous solution. To evaluate the potential these polymeric carrier, PSI-mPEG--ED conjugated with Cy5.5 for...
Background: Levodropropizine is a non-opioid antitussive agent that inhibits cough reflex by reducing the release of sensory peptide in peripheral region. To improve patients' compliance, controlled-release (CR) tablet under development. The aim this study was to compare pharmacokinetic (PK) profiles CR and immediate-release (IR) tablets levodropropizine. In addition, effect food on PK properties levodropropizine healthy subjects evaluated. Subjects methods: A randomized, open-label,...