A5059850426- Porphyrin Metabolism and Disorders
- Palliative Care and End-of-Life Issues
- Heme Oxygenase-1 and Carbon Monoxide
- Methemoglobinemia and Tumor Lysis Syndrome
- Sepsis Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Patient Dignity and Privacy
- Healthcare Decision-Making and Restraints
- Intensive Care Unit Cognitive Disorders
- Folate and B Vitamins Research
- S100 Proteins and Annexins
- Neonatal Health and Biochemistry
- Family and Patient Care in Intensive Care Units
- Grief, Bereavement, and Mental Health
- Regulation of Appetite and Obesity
- Alcoholism and Thiamine Deficiency
- Nutritional Studies and Diet
- Immune Cell Function and Interaction
- Patient-Provider Communication in Healthcare
- IL-33, ST2, and ILC Pathways
- Autoimmune and Inflammatory Disorders Research
- COVID-19 diagnosis using AI
- SARS-CoV-2 and COVID-19 Research
- Neurological and metabolic disorders
- SARS-CoV-2 detection and testing
Humboldt-Universität zu Berlin
2020-2025
Charité - Universitätsmedizin Berlin
2020-2025
Freie Universität Berlin
2020-2025
Deutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin
2023
Franklin University
2023
Klinikum Chemnitz
2023
TU Dresden
2023
Universität Ulm
2015
IL-22 plays a critical role in defending against mucosal infections, but how production is regulated incompletely understood. Here, we show that mice lacking IL-33 or its receptor ST2 (IL-1RL1) were more resistant to Streptococcus pneumoniae lung infection than wild-type animals and single-nucleotide polymorphisms IL33 IL1RL1 associated with pneumococcal pneumonia humans. The effect of on S. was mediated by negative regulation innate lymphoid cells (ILCs) independent ILC2s as well IL-4 IL-13...
Background and importance mRNA-based host response signatures have been reported to improve sepsis diagnostics. Meanwhile, prognostic markers for the rapid accurate prediction of severity in patients with suspected acute infections remain an unmet need. IMX-SEV-2 is a 29-host-mRNA classifier designed predict disease infection or sepsis. Objective Validation host-mRNA IMX-SEV-2. Design, settings participants Prospective, observational, convenience cohort emergency department (ED) infections....
Abstract Background Early in the host-response to infection, neutrophils release calprotectin, triggering several immune signalling cascades. In acute infection management, identifying infected patients and stratifying these by risk of deterioration into sepsis, are crucial tasks. Recruiting a heterogenous population with suspected infections from emergency department, early care-path, CASCADE trial aimed evaluate accuracy blood calprotectin for detecting bacterial infections, estimating...
Total and central adiposity have been associated with increased risk of Alzheimer's disease (AD). Visceral subcutaneous adipose tissues different metabolic characteristics could therefore be differentially AD.To compare regional fat distribution determined by magnetic resonance imaging (MRI) in AD patients healthy controls investigate associations stage the chemical markers. The investigation was performed a prospective case-control study.We examined thirty mild to moderate whole-body MRI...
Background: We evaluated how plasma proteomic signatures in patients with suspected COVID-19 can unravel the pathophysiology, and determine kinetics clinical outcome of infection. Methods: Plasma samples from presenting to emergency department (ED) symptoms were stratified into: (1) that was not confirmed (n = 44); (2) non-hospitalized (3) hospitalized 53) variable outcome; (4) ED minor diseases unrelated SARS-CoV-2 infection 20). Besides standard care diagnostics, 177 circulating proteins...
: Acute intermittent porphyria (AIP) is a metabolic disease characterised by neurovisceral crises with episodes of acute abdominal pain alongside life-altering, and often hidden, chronic symptoms. The elimination precipitating factors, hemin therapy, relief are strategies used to treat symptoms, but reserved for patients suffering recurrent, attacks. Givosiran (siRNA) an emerging AIP therapy capable silencing delta-aminolevulinic acid synthase-1 (ALAS1) and, in turn, reducing the...
Abstract Background Acute porphyrias (APs) are a group of rare metabolic diseases related to disturbed heme biosynthesis. Symptoms may first occur as life threatening attacks, comprising abdominal pain and/or variable neuro-psychiatric symptoms, thus leading presentation in emergency departments (ED) first. Due the low prevalence, diagnosis AP is often missed, even after readmission ED. Therefore, strategies needed consider APs ED patients with unexplained pain, especially since early and...
Zusammenfassung Patienten mit lebenslimitierenden/palliativen Erkrankungen stellen eine Herausforderung für die Klinische Akut- und Notfallmedizin dar, denn trotz zunehmend ausgebauter Strukturen der spezialisierten ambulanten Palliativversorgung (SAPV) ist Notaufnahme bei Symptomexazerbationen oder Überlastung Angehörigen häufig erste Anlaufstelle. Da hier ebenso lebenslimitierende erstdiagnostiziert Therapieziele angepasst werden, scheint frühzeitige Anbindung von Notfallpatient:innen an...
Porphyrias, as most rare diseases, are characterized by complexity and scarcity of knowledge. A national registry in one the largest European populations that prospectively collects longitudinal clinical laboratory data an important effective tool to close this gap. The German Porphyria Registry (PoReGer) was founded four centers with longstanding expertise field porphyrias diseases (Charité–Universitätsmedizin Berlin, Center Saxony Chemnitz, University Medical Hamburg-Eppendorf, Göttingen)...
Porphyrias are predominantly genetic metabolic disorders caused by dysregulation of specific enzymes in porphyrin-heme biosynthesis. The enzymatic dysfunction leads to formation and excretion intermediate products the form porphyrins and/or their precursors δ‑aminolevulinic acid porphobilinogen, which have cyto- tissue-toxic properties. Clinically, porphyrias extremely diverse, with symptoms ranging from skin changes on light-exposed areas body potentially life-threatening neurovisceral...
Abstract Background Acute infections and sepsis are a leading cause of death. These patients primarily encountered at the emergency department (ED), where early assessment for is necessary to improve outcome. In sepsis, inflammatory response causes several characteristic pathophysiological changes, including dysregulated generalized activation endothelium. This study aimed analyse endothelial markers released blood as diagnostic biomarkers acute infection in ED, smaller studies have...
An effective testing strategy is essential for pandemic control of the novel Coronavirus disease 2019 (COVID-19) caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Breath gas analysis can expand available toolbox diagnostic tests using a rapid, cost-beneficial, high-throughput point-of-care test. We conducted bi-center clinical pilot study in Germany to evaluate breath multi-capillary column ion mobility spectrometry (MCC-IMS) detect SARS-CoV-2 infection....